FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519844524> ?p ?o ?g. }

• W1519844524 endingPage "1143" @default.
• W1519844524 startingPage "1132" @default.
• W1519844524 abstract "We report the complete sequence of a calcium channel alpha 1 subunit cDNA cloned from a Drosophila head cDNA library. This cDNA encodes a deduced protein containing 2516 amino acids with a predicted molecular weight of 276,493. The deduced protein shares many features with vertebrate homologs, including four repeat structures, each containing six transmembrane domains, a conserved ion selectivity filter region between transmembrane domains 5 and 6, and an EF hand in the carboxy tail. The Drosophila subunit has unusually long initial amino and terminal carboxy tails. The region corresponding to the last transmembrane domain (IVS6) and the adjacent cytoplasmic domain has been postulated to form a phenylalkylamine-binding site in vertebrate calcium channels. This region is conserved in the Drosophila sequence, while domains thought to be involved in dihydropyridine binding show numerous changes. The Drosophila subunit exhibits 78.3% sequence similarity to the rat brain type D calcium channel alpha 1 subunit, and so has been designated as a Drosophila melanogaster calcium channel alpha 1 type D subunit (Dmca1D). In situ hybridization shows that Dmca1D is highly expressed in the embryonic nervous system. Northern analysis shows that Dmca1D cDNA hybridizes to three size classes of mRNA (9.5, 10.2, and 12.5 kb) in heads, but only two classes (9.5 and 12.5 kb) in bodies and legs. PCR analysis suggests that the Dmca1D message undergoes alternative splicing with more heterogeneity appearing in head and embryonic extracts than in bodies and legs." @default.
• W1519844524 created "2016-06-24" @default.
• W1519844524 creator A5005121699 @default.
• W1519844524 creator A5010578085 @default.
• W1519844524 creator A5014241947 @default.
• W1519844524 creator A5018416759 @default.
• W1519844524 creator A5035735276 @default.
• W1519844524 creator A5057140194 @default.
• W1519844524 creator A5081570041 @default.
• W1519844524 date "1995-02-01" @default.
• W1519844524 modified "2023-10-14" @default.
• W1519844524 title "Cloning and characterization of a calcium channel alpha 1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform" @default.
• W1519844524 cites W1550439343 @default.
• W1519844524 cites W1585798997 @default.
• W1519844524 cites W1627770206 @default.
• W1519844524 cites W1685356864 @default.
• W1519844524 cites W1839063390 @default.
• W1519844524 cites W1965163623 @default.
• W1519844524 cites W1966765745 @default.
• W1519844524 cites W1971844027 @default.
• W1519844524 cites W1974015977 @default.
• W1519844524 cites W1975304761 @default.
• W1519844524 cites W1983635763 @default.
• W1519844524 cites W1993117363 @default.
• W1519844524 cites W1996196738 @default.
• W1519844524 cites W1996437700 @default.
• W1519844524 cites W2007938471 @default.
• W1519844524 cites W2011806481 @default.
• W1519844524 cites W2014908429 @default.
• W1519844524 cites W2022236187 @default.
• W1519844524 cites W2022614248 @default.
• W1519844524 cites W2024781640 @default.
• W1519844524 cites W2027351968 @default.
• W1519844524 cites W2028844925 @default.
• W1519844524 cites W2036937904 @default.
• W1519844524 cites W2037048489 @default.
• W1519844524 cites W2042036078 @default.
• W1519844524 cites W2042079698 @default.
• W1519844524 cites W2051789222 @default.
• W1519844524 cites W2055360673 @default.
• W1519844524 cites W2057461568 @default.
• W1519844524 cites W2068617048 @default.
• W1519844524 cites W2073934947 @default.
• W1519844524 cites W2074445666 @default.
• W1519844524 cites W2076095787 @default.
• W1519844524 cites W2079353889 @default.
• W1519844524 cites W2084285144 @default.
• W1519844524 cites W2084748812 @default.
• W1519844524 cites W2087651417 @default.
• W1519844524 cites W2087671622 @default.
• W1519844524 cites W2090157435 @default.
• W1519844524 cites W2091239909 @default.
• W1519844524 cites W2091321002 @default.
• W1519844524 cites W2093911044 @default.
• W1519844524 cites W2094362927 @default.
• W1519844524 cites W2094471348 @default.
• W1519844524 cites W2114457659 @default.
• W1519844524 cites W2118309627 @default.
• W1519844524 cites W2134353614 @default.
• W1519844524 cites W2180452219 @default.
• W1519844524 cites W2321590196 @default.
• W1519844524 cites W2402785197 @default.
• W1519844524 cites W2415036336 @default.
• W1519844524 doi "https://doi.org/10.1523/jneurosci.15-02-01132.1995" @default.
• W1519844524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6577841" @default.
• W1519844524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7869089" @default.
• W1519844524 hasPublicationYear "1995" @default.
• W1519844524 type Work @default.
• W1519844524 sameAs 1519844524 @default.
• W1519844524 citedByCount "75" @default.
• W1519844524 countsByYear W15198445242012 @default.
• W1519844524 countsByYear W15198445242013 @default.
• W1519844524 countsByYear W15198445242015 @default.
• W1519844524 countsByYear W15198445242017 @default.
• W1519844524 countsByYear W15198445242018 @default.
• W1519844524 countsByYear W15198445242020 @default.
• W1519844524 countsByYear W15198445242022 @default.
• W1519844524 countsByYear W15198445242023 @default.
• W1519844524 crossrefType "journal-article" @default.
• W1519844524 hasAuthorship W1519844524A5005121699 @default.
• W1519844524 hasAuthorship W1519844524A5010578085 @default.
• W1519844524 hasAuthorship W1519844524A5014241947 @default.
• W1519844524 hasAuthorship W1519844524A5018416759 @default.
• W1519844524 hasAuthorship W1519844524A5035735276 @default.
• W1519844524 hasAuthorship W1519844524A5057140194 @default.
• W1519844524 hasAuthorship W1519844524A5081570041 @default.
• W1519844524 hasBestOaLocation W15198445241 @default.
• W1519844524 hasConcept C104292427 @default.
• W1519844524 hasConcept C104317684 @default.
• W1519844524 hasConcept C118892022 @default.
• W1519844524 hasConcept C153911025 @default.
• W1519844524 hasConcept C167625842 @default.
• W1519844524 hasConcept C170493617 @default.
• W1519844524 hasConcept C178790620 @default.
• W1519844524 hasConcept C185592680 @default.
• W1519844524 hasConcept C187882448 @default.
• W1519844524 hasConcept C189482833 @default.
• W1519844524 hasConcept C194583182 @default.

• next