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- W1519879709 abstract "We hypothesized that exposure to hyperbaric oxygen (HBO2) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (.NO) dependent mechanism. The population of CD34+ cells in the peripheral circulation of humans (n=23) doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O2 for 2 hours. Over a course of twenty treatments, circulating CD34+ cells increased eightfold, although the over-all circulating white cell count was not significantly increased. The number of colony-forming cells (CFCs) increased from 16 +/− 2 to 26 +/− 3 CFCs/100,000 monocytes plated. Elevations in CFCs were entirely due to the CD34+ sub-population, but increased cell growth only occurred in samples obtained immediately post-treatment. A high proportion of progeny cells express receptors for vascular endothelial growth factor-2 and for stromal derived growth factor. In mice, HBO2 increased circulating stem cell factor by 50%, increased the number of circulating cells expressing stem cell antigen-1 and CD34 by 3.4-fold, and doubled the number of CFCs. Bone marrow .NO concentration increased by 1008 + 255 nM in association with HBO2. Stem cell mobilization did not occur in knock out mice lacking genes for endothelial .NO synthase. Moreover, pre-treatment of wild type mice with a nitric oxide (.NO) synthase inhibitor prevented the HBO2-induced elevation in stem cell factor and circulating stem cells. We conclude that HBO2 mobilizes stem/progenitor cells by stimulating .NO synthesis. Supported by NIH grant AT00428." @default.
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- W1519879709 date "2006-03-01" @default.
- W1519879709 modified "2023-09-25" @default.
- W1519879709 title "Stem cell mobilization by hyperbaric oxygen" @default.
- W1519879709 doi "https://doi.org/10.1096/fasebj.20.5.a1460" @default.
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