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- W151996607 endingPage "311" @default.
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- W151996607 abstract "The brain contains both angiotensin II (Ang II) type 1 (AT1) and Ang II type 2 (AT2) receptors. Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood pressure, water and salt intake, and secretion of vasopressin. In contrast, neuronal AT2 receptors have been implicated in the stimulation of apoptosis and as being antagonistic to AT1 receptors. The physiological actions of Ang II in the brain, whether mediated by AT1 or AT2 receptors, involve changes in neuronal activity that are initiated by changes in the activity of membrane ionic currents and channels. This review focusses on the intracellular signalling pathways that couple neuronal AT1 and AT2 receptors to changes in the activity of membrane K+ and Ca2+ currents and channels. As will become clear from our discussion, the signalling pathways that are modulated by neuronal AT1 and AT2 receptors are quite distinct." @default.
- W151996607 created "2016-06-24" @default.
- W151996607 creator A5004651591 @default.
- W151996607 creator A5041646295 @default.
- W151996607 date "1998-05-01" @default.
- W151996607 modified "2023-09-27" @default.
- W151996607 title "Neuronal Ion Channel Signalling Pathways" @default.
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