FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519982502> ?p ?o ?g. }

• W1519982502 endingPage "3701" @default.
• W1519982502 startingPage "3691" @default.
• W1519982502 abstract "Resistance exercise induces a hypertrophic response in skeletal muscle and recent studies have begun to shed light on the molecular mechanisms involved in this process. For example, several studies indicate that signalling by the mammalian target of rapamycin (mTOR) is necessary for a hypertrophic response. Furthermore, resistance exercise has been proposed to activate mTOR signalling through an upstream pathway involving the phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB); however, this hypothesis has not been thoroughly tested. To test this hypothesis, we first evaluated the temporal pattern of signalling through PI3K-PKB and mTOR following a bout of resistance exercise with eccentric contractions (EC). Our results indicated that the activation of signalling through PI3K-PKB is a transient event (<15 min), while the activation of mTOR is sustained for a long duration (>12 h). Furthermore, inhibition of PI3K-PKB activity did not prevent the activation of mTOR signalling by ECs, indicating that PI3K-PKB is not part of the upstream regulatory pathway. These observations led us to investigate an alternative pathway for the activation of mTOR signalling involving the synthesis of phosphatidic acid (PA) by phospholipase D (PLD). Our results demonstrate that ECs induce a sustained elevation in [PA] and inhibiting the synthesis of PA by PLD prevented the activation of mTOR. Furthermore, we determined that similar to ECs, PA activates mTOR signalling through a PI3K-PKB-independent mechanism. Combined, the results of this study indicate that the activation of mTOR following eccentric contractions occurs through a PI3K-PKB-independent mechanism that requires PLD and PA." @default.
• W1519982502 created "2016-06-24" @default.
• W1519982502 creator A5009929392 @default.
• W1519982502 creator A5050577395 @default.
• W1519982502 creator A5051166768 @default.
• W1519982502 creator A5051527512 @default.
• W1519982502 date "2009-07-14" @default.
• W1519982502 modified "2023-10-14" @default.
• W1519982502 title "The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions" @default.
• W1519982502 cites W1530473805 @default.
• W1519982502 cites W1556893777 @default.
• W1519982502 cites W1586159393 @default.
• W1519982502 cites W1926614894 @default.
• W1519982502 cites W1979850916 @default.
• W1519982502 cites W1982501876 @default.
• W1519982502 cites W1988209118 @default.
• W1519982502 cites W1990911170 @default.
• W1519982502 cites W1995480133 @default.
• W1519982502 cites W1997642684 @default.
• W1519982502 cites W2001505809 @default.
• W1519982502 cites W2002959031 @default.
• W1519982502 cites W2013185671 @default.
• W1519982502 cites W2014031706 @default.
• W1519982502 cites W2028875959 @default.
• W1519982502 cites W2035965301 @default.
• W1519982502 cites W2040498801 @default.
• W1519982502 cites W2044328618 @default.
• W1519982502 cites W2051037257 @default.
• W1519982502 cites W2052575670 @default.
• W1519982502 cites W2060011023 @default.
• W1519982502 cites W2063515332 @default.
• W1519982502 cites W2072549960 @default.
• W1519982502 cites W2075614417 @default.
• W1519982502 cites W2081305406 @default.
• W1519982502 cites W2102888099 @default.
• W1519982502 cites W2105981385 @default.
• W1519982502 cites W2107033751 @default.
• W1519982502 cites W2110966981 @default.
• W1519982502 cites W2116738170 @default.
• W1519982502 cites W2117789591 @default.
• W1519982502 cites W2120895907 @default.
• W1519982502 cites W2132683439 @default.
• W1519982502 cites W2132806001 @default.
• W1519982502 cites W2132886183 @default.
• W1519982502 cites W2135792781 @default.
• W1519982502 cites W2148625376 @default.
• W1519982502 cites W2159132862 @default.
• W1519982502 cites W2165047367 @default.
• W1519982502 cites W2168107233 @default.
• W1519982502 cites W2168526937 @default.
• W1519982502 cites W2168831512 @default.
• W1519982502 cites W2168947306 @default.
• W1519982502 cites W2172252111 @default.
• W1519982502 cites W2339005651 @default.
• W1519982502 doi "https://doi.org/10.1113/jphysiol.2009.173609" @default.
• W1519982502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2742291" @default.
• W1519982502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19470781" @default.
• W1519982502 hasPublicationYear "2009" @default.
• W1519982502 type Work @default.
• W1519982502 sameAs 1519982502 @default.
• W1519982502 citedByCount "204" @default.
• W1519982502 countsByYear W15199825022012 @default.
• W1519982502 countsByYear W15199825022013 @default.
• W1519982502 countsByYear W15199825022014 @default.
• W1519982502 countsByYear W15199825022015 @default.
• W1519982502 countsByYear W15199825022016 @default.
• W1519982502 countsByYear W15199825022017 @default.
• W1519982502 countsByYear W15199825022018 @default.
• W1519982502 countsByYear W15199825022019 @default.
• W1519982502 countsByYear W15199825022020 @default.
• W1519982502 countsByYear W15199825022021 @default.
• W1519982502 countsByYear W15199825022022 @default.
• W1519982502 countsByYear W15199825022023 @default.
• W1519982502 crossrefType "journal-article" @default.
• W1519982502 hasAuthorship W1519982502A5009929392 @default.
• W1519982502 hasAuthorship W1519982502A5050577395 @default.
• W1519982502 hasAuthorship W1519982502A5051166768 @default.
• W1519982502 hasAuthorship W1519982502A5051527512 @default.
• W1519982502 hasBestOaLocation W15199825022 @default.
• W1519982502 hasConcept C185592680 @default.
• W1519982502 hasConcept C2776909261 @default.
• W1519982502 hasConcept C2778918659 @default.
• W1519982502 hasConcept C2781322055 @default.
• W1519982502 hasConcept C41625074 @default.
• W1519982502 hasConcept C55493867 @default.
• W1519982502 hasConcept C62478195 @default.
• W1519982502 hasConcept C75217442 @default.
• W1519982502 hasConcept C86554907 @default.
• W1519982502 hasConcept C86803240 @default.
• W1519982502 hasConcept C95444343 @default.
• W1519982502 hasConceptScore W1519982502C185592680 @default.
• W1519982502 hasConceptScore W1519982502C2776909261 @default.
• W1519982502 hasConceptScore W1519982502C2778918659 @default.
• W1519982502 hasConceptScore W1519982502C2781322055 @default.
• W1519982502 hasConceptScore W1519982502C41625074 @default.
• W1519982502 hasConceptScore W1519982502C55493867 @default.
• W1519982502 hasConceptScore W1519982502C62478195 @default.
• W1519982502 hasConceptScore W1519982502C75217442 @default.

• next