Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519996291> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1519996291 endingPage "374" @default.
- W1519996291 startingPage "369" @default.
- W1519996291 abstract "Therapy-related leukemia has been a recognized sequela of cancer treatment for decades with “signature” abnormalities of chromosomes 5, 7, and 11 observed in treated patients. Risk to oncology personnel handling anti-cancer agents has also been documented by non-specific measures of genotoxicity in blood and urine. Using chromosomal markers applied in clinical practice, we previously demonstrated in oncology workers, a dose-related increase in abnormalities of chromosomes 5 and 7, known to be targets of alkylating agent exposure. In the analysis presented here, we extended that work to also assess damage resulting from non-alkylating drug exposure. Peripheral blood lymphocytes from oncology personnel (N = 63) and non-exposed controls (N = 46) was collected and examined using the fluorescent in situ hybridization technique with probes for targets on chromosomes 5, 7, and 11. Participants recorded drug handling events over a 6 week period. Important co-variates were considered. Examining chromosomal outcomes as a function of drug handling frequency, we employed Poisson Regression to obtain incident rate ratios (IRRs) for selected drug handling frequencies. We found a dose-related increase in the IRR for aberrations in all three chromosomes 5, 7, and 11, reaching statistical significance for chromosome 5, as a function of non-alkylating drug handling. This suggests that the targeting of chromosome 5 is not limited to alkylating agent exposure, as some recent evidence in treated patients has also shown. Thus, the pattern of insult observed in treated patients appears to extend to oncology personnel exposed in the workplace. Environ. Mol. Mutagen. 55:369–374, 2014. © 2014 Wiley Periodicals, Inc." @default.
- W1519996291 created "2016-06-24" @default.
- W1519996291 creator A5006004223 @default.
- W1519996291 creator A5021101478 @default.
- W1519996291 creator A5069263071 @default.
- W1519996291 date "2014-01-21" @default.
- W1519996291 modified "2023-10-18" @default.
- W1519996291 title "Chromosomal effects of non-alkylating drug exposure in oncology personnel" @default.
- W1519996291 cites W1975793150 @default.
- W1519996291 cites W1994791499 @default.
- W1519996291 cites W2000846352 @default.
- W1519996291 cites W2008401150 @default.
- W1519996291 cites W2010693099 @default.
- W1519996291 cites W2025922707 @default.
- W1519996291 cites W2033918402 @default.
- W1519996291 cites W2047991220 @default.
- W1519996291 cites W2053220606 @default.
- W1519996291 cites W2057140174 @default.
- W1519996291 cites W2058225762 @default.
- W1519996291 cites W2077404665 @default.
- W1519996291 cites W2078792348 @default.
- W1519996291 cites W2103548497 @default.
- W1519996291 cites W2122614008 @default.
- W1519996291 cites W2123103213 @default.
- W1519996291 cites W2130406892 @default.
- W1519996291 cites W2346419124 @default.
- W1519996291 cites W2405099813 @default.
- W1519996291 cites W2411184906 @default.
- W1519996291 doi "https://doi.org/10.1002/em.21852" @default.
- W1519996291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24449410" @default.
- W1519996291 hasPublicationYear "2014" @default.
- W1519996291 type Work @default.
- W1519996291 sameAs 1519996291 @default.
- W1519996291 citedByCount "16" @default.
- W1519996291 countsByYear W15199962912016 @default.
- W1519996291 countsByYear W15199962912017 @default.
- W1519996291 countsByYear W15199962912018 @default.
- W1519996291 countsByYear W15199962912019 @default.
- W1519996291 countsByYear W15199962912020 @default.
- W1519996291 countsByYear W15199962912021 @default.
- W1519996291 countsByYear W15199962912022 @default.
- W1519996291 countsByYear W15199962912023 @default.
- W1519996291 crossrefType "journal-article" @default.
- W1519996291 hasAuthorship W1519996291A5006004223 @default.
- W1519996291 hasAuthorship W1519996291A5021101478 @default.
- W1519996291 hasAuthorship W1519996291A5069263071 @default.
- W1519996291 hasConcept C121608353 @default.
- W1519996291 hasConcept C126322002 @default.
- W1519996291 hasConcept C143998085 @default.
- W1519996291 hasConcept C2780035454 @default.
- W1519996291 hasConcept C2908647359 @default.
- W1519996291 hasConcept C71924100 @default.
- W1519996291 hasConcept C73269764 @default.
- W1519996291 hasConcept C86803240 @default.
- W1519996291 hasConcept C98274493 @default.
- W1519996291 hasConcept C99454951 @default.
- W1519996291 hasConceptScore W1519996291C121608353 @default.
- W1519996291 hasConceptScore W1519996291C126322002 @default.
- W1519996291 hasConceptScore W1519996291C143998085 @default.
- W1519996291 hasConceptScore W1519996291C2780035454 @default.
- W1519996291 hasConceptScore W1519996291C2908647359 @default.
- W1519996291 hasConceptScore W1519996291C71924100 @default.
- W1519996291 hasConceptScore W1519996291C73269764 @default.
- W1519996291 hasConceptScore W1519996291C86803240 @default.
- W1519996291 hasConceptScore W1519996291C98274493 @default.
- W1519996291 hasConceptScore W1519996291C99454951 @default.
- W1519996291 hasIssue "4" @default.
- W1519996291 hasLocation W15199962911 @default.
- W1519996291 hasLocation W15199962912 @default.
- W1519996291 hasOpenAccess W1519996291 @default.
- W1519996291 hasPrimaryLocation W15199962911 @default.
- W1519996291 hasRelatedWork W1983544050 @default.
- W1519996291 hasRelatedWork W2125138090 @default.
- W1519996291 hasRelatedWork W2141845144 @default.
- W1519996291 hasRelatedWork W2365364931 @default.
- W1519996291 hasRelatedWork W2418638721 @default.
- W1519996291 hasRelatedWork W2426261983 @default.
- W1519996291 hasRelatedWork W2794783788 @default.
- W1519996291 hasRelatedWork W3024440267 @default.
- W1519996291 hasRelatedWork W4213271907 @default.
- W1519996291 hasRelatedWork W4226515308 @default.
- W1519996291 hasVolume "55" @default.
- W1519996291 isParatext "false" @default.
- W1519996291 isRetracted "false" @default.
- W1519996291 magId "1519996291" @default.
- W1519996291 workType "article" @default.