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• W1520002759 abstract "Recent CSF and postmortem brain hypocretin measurements in human narcolepsy suggest that hypocretin deficiency is involved in the pathophysiology of the disease. Thus, it is important to study whether neurological disorders also have abnormal CSF hypocretin levels. We therefore measured hypocretins in the CSF of various neurological disorders and obstructive sleep apnea syndrome (OSAS) to identify altered hypocretin levels. CSF hypocretin levels in patients with OSAS and neurological diseases were almost within the normal range in Japanese populations. While, hypocretin levels in patients with narcolepsy-cataplexy are very low. The measurement of hypocretin levels is a useful diagnostic tool in Japanese patients with narcolepsycataplexy. Key word : Hypocretin, Narcolepsy, OSAS Correspondence : Kou Tsutsui Department of Neuropsychiatry, Akita University Graduate School of Medicine, 1-1-1 Hondoh, Akita 010-8543, Japan Tel : 81-18-884-6122 Fax : 81-18-884-6445 E-mail : tsutsui@psy.med.akita-u.ac.jp Introduction Narcolepsy is characterized by excessive daytime sleepiness, cataplexy and other abnormal manifestations of REM sleep, such as sleep paralysis and hypnagogic hallucinations (i.e. narcolepsy tetrad) as well as disturbed nighttime sleep (i.e. narcolepsy pentad). This sleep disorder affecting 1/600 Japanese, is associated with HLADR2 (DQB1*0602) -. Recent CSF and postmortem brain hypocretin measurements in human narcolepsy suggest that hypocretin deficiency is involved in the pathophysiology of the disease. Thus, it is important to study whether neurological disorders also have abnormal CSF hypocretin levels. We therefore measured hypocretins in the CSF of various neurological disorders and obstructive sleep apnea syndrome (OSAS) to identify altered hypocretin levels. The results will also be useful in further evaluating the specificity of low hypocretin levels in narcolepsy-cataplexy among Japanese populations." @default.
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• W1520002759 date "2011-06-01" @default.
• W1520002759 modified "2023-09-28" @default.
• W1520002759 title "CSF HYPOCRETIN CONCENTRATION IN VARIOUS NEUROLOGICAL AND SLEEP DISORDERS" @default.
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