FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520032679> ?p ?o ?g. }

• W1520032679 endingPage "988" @default.
• W1520032679 startingPage "971" @default.
• W1520032679 abstract "Experimental tumors, growths both morphologically and functionally comparable to androblastomas or arrhenoblastomas, can be produced in fowl by destruction of the functional left ovary and resultant overgrowth of the vestigial right gonad. However, identical growths frequently result when radioactive colloidal chromic phosphate is injected into the left ovaries of hens and rarely when the testes of roosters are traumatized or treated with caustic chemicals. The growths which result when ovarian or testicular tissue is transplanted into the spleen or thymus of castrated rats and the tubular complexes which form spontaneously in the ovaries of aged rats are strikingly similar to the lesions in the birds. Both the rodent and the avian gonadal overgrowths resemble certain spontaneous tumors of the dog's testis and the human ovary or testis. The homology of Sertoli to granulosa cells and of theca-lutein elements to Leydig cells has been recognized by experimental and comparative embryologists. In the light of these homologies, the tumors can be viewed as neoplasms made up of cells which have retained their embryonic bipotential capacities, and which can differentiate toward elements resembling nongerminal epithelial and supporting structures of the gonad of either sex. This concept is supported by evidence that nongerminal cells capable of division and differentiation exist in the adult gonad of both sexes and that in experimental tumorigenesis it is these cells which participate rather than vestigial structures or embryonic rests. Endocrinologic activity of the tumor depends on the types, relative proportions, and degrees of differentiation of the hormonesecreting cells, which vary considerably from neoplasm to neoplasm. Hormonal secretion alone does not constitute an adequate basis for nomenclature. The common histogenesis of granulosa cell tumors, arrhenoblastomas, lutcomas, and Leydig cell tumors of the ovary, as well as of the Sertoli cell tumors (tubular androblastomas), diffuse androblastomas, and granulosa and interstitial cell tumors of the testis is emphasized. A generic designation for the entire group, which would emphasize the common histogenesis, would be desirable, and the old term “gynandroblastoma” is suggested. “Androblastoma” and “gynoblastoma” are proposed as names for the subtypes, depending upon whether the direction of differentiation is toward tubules and interstitial cells or toward stroma and follicular complexes, and, if needed, the adjectival designations of “masculinizing” or “femininizing” could be used to indicate functional activity." @default.
• W1520032679 created "2016-06-24" @default.
• W1520032679 creator A5029160724 @default.
• W1520032679 creator A5052396777 @default.
• W1520032679 creator A5056636404 @default.
• W1520032679 creator A5071026868 @default.
• W1520032679 date "1960-05-01" @default.
• W1520032679 modified "2023-09-23" @default.
• W1520032679 title "Comparative pathology of experimental and spontaneous androblastomas and gynoblastomas of the gonads" @default.
• W1520032679 cites W108990921 @default.
• W1520032679 cites W1561703067 @default.
• W1520032679 cites W1702421816 @default.
• W1520032679 cites W170329236 @default.
• W1520032679 cites W1977318613 @default.
• W1520032679 cites W1982201547 @default.
• W1520032679 cites W2004922965 @default.
• W1520032679 cites W2007666105 @default.
• W1520032679 cites W2015082342 @default.
• W1520032679 cites W2028396741 @default.
• W1520032679 cites W2036687689 @default.
• W1520032679 cites W2044439291 @default.
• W1520032679 cites W2051978431 @default.
• W1520032679 cites W2063135697 @default.
• W1520032679 cites W2089762067 @default.
• W1520032679 cites W2103783236 @default.
• W1520032679 cites W2108080018 @default.
• W1520032679 cites W2118240164 @default.
• W1520032679 cites W2151323892 @default.
• W1520032679 cites W2395486241 @default.
• W1520032679 cites W2395887212 @default.
• W1520032679 cites W2404400604 @default.
• W1520032679 cites W4246039434 @default.
• W1520032679 cites W4380763390 @default.
• W1520032679 cites W2039438478 @default.
• W1520032679 doi "https://doi.org/10.1016/0002-9378(60)90693-1" @default.
• W1520032679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13842918" @default.
• W1520032679 hasPublicationYear "1960" @default.
• W1520032679 type Work @default.
• W1520032679 sameAs 1520032679 @default.
• W1520032679 citedByCount "14" @default.
• W1520032679 countsByYear W15200326792013 @default.
• W1520032679 countsByYear W15200326792019 @default.
• W1520032679 crossrefType "journal-article" @default.
• W1520032679 hasAuthorship W1520032679A5029160724 @default.
• W1520032679 hasAuthorship W1520032679A5052396777 @default.
• W1520032679 hasAuthorship W1520032679A5056636404 @default.
• W1520032679 hasAuthorship W1520032679A5071026868 @default.
• W1520032679 hasConcept C104317684 @default.
• W1520032679 hasConcept C105702510 @default.
• W1520032679 hasConcept C123765429 @default.
• W1520032679 hasConcept C126322002 @default.
• W1520032679 hasConcept C134018914 @default.
• W1520032679 hasConcept C142724271 @default.
• W1520032679 hasConcept C145103041 @default.
• W1520032679 hasConcept C148102462 @default.
• W1520032679 hasConcept C196843134 @default.
• W1520032679 hasConcept C2778324911 @default.
• W1520032679 hasConcept C2781068068 @default.
• W1520032679 hasConcept C2781471917 @default.
• W1520032679 hasConcept C54355233 @default.
• W1520032679 hasConcept C71924100 @default.
• W1520032679 hasConcept C86803240 @default.
• W1520032679 hasConcept C87073359 @default.
• W1520032679 hasConcept C95444343 @default.
• W1520032679 hasConceptScore W1520032679C104317684 @default.
• W1520032679 hasConceptScore W1520032679C105702510 @default.
• W1520032679 hasConceptScore W1520032679C123765429 @default.
• W1520032679 hasConceptScore W1520032679C126322002 @default.
• W1520032679 hasConceptScore W1520032679C134018914 @default.
• W1520032679 hasConceptScore W1520032679C142724271 @default.
• W1520032679 hasConceptScore W1520032679C145103041 @default.
• W1520032679 hasConceptScore W1520032679C148102462 @default.
• W1520032679 hasConceptScore W1520032679C196843134 @default.
• W1520032679 hasConceptScore W1520032679C2778324911 @default.
• W1520032679 hasConceptScore W1520032679C2781068068 @default.
• W1520032679 hasConceptScore W1520032679C2781471917 @default.
• W1520032679 hasConceptScore W1520032679C54355233 @default.
• W1520032679 hasConceptScore W1520032679C71924100 @default.
• W1520032679 hasConceptScore W1520032679C86803240 @default.
• W1520032679 hasConceptScore W1520032679C87073359 @default.
• W1520032679 hasConceptScore W1520032679C95444343 @default.
• W1520032679 hasIssue "5" @default.
• W1520032679 hasLocation W15200326791 @default.
• W1520032679 hasLocation W15200326792 @default.
• W1520032679 hasOpenAccess W1520032679 @default.
• W1520032679 hasPrimaryLocation W15200326791 @default.
• W1520032679 hasRelatedWork W1967279915 @default.
• W1520032679 hasRelatedWork W1978357546 @default.
• W1520032679 hasRelatedWork W2000206763 @default.
• W1520032679 hasRelatedWork W2056872482 @default.
• W1520032679 hasRelatedWork W2077416684 @default.
• W1520032679 hasRelatedWork W2078753179 @default.
• W1520032679 hasRelatedWork W2102164644 @default.
• W1520032679 hasRelatedWork W2136785547 @default.
• W1520032679 hasRelatedWork W2769593743 @default.
• W1520032679 hasRelatedWork W942976272 @default.
• W1520032679 hasVolume "79" @default.
• W1520032679 isParatext "false" @default.

• next