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- W1520089072 endingPage "1792" @default.
- W1520089072 startingPage "1780" @default.
- W1520089072 abstract "In mammals, urea is the main nitrogenous breakdown product of protein catabolism and is produced in the liver. In certain tissues, the movement of urea across cell membranes is specifically mediated by a group of proteins known as the SLC14A family of facilitative urea transporters. These proteins are derived from two distinct genes, UT-A (SLC14A2) and UT-B (SLC14A1). Facilitative urea transporters play an important role in two major physiological processes - urinary concentration and urea nitrogen salvaging. Although UT-A and UT-B transporters both have a similar basic structure and mediate the transport of urea in a facilitative manner, there are a number of significant differences between them. UT-A transporters are mainly found in the kidney, are highly specific for urea, have relatively lower transport rates and are highly regulated at both gene expression and cellular localization levels. In contrast, UT-B transporters are more widespread in their tissue location, transport both urea and water, have a relatively high transport rate, are inhibited by mercurial compounds and currently appear to be less acutely regulated. This review details the fundamental research that has so far been performed to investigate the function and physiological significance of these two types of urea transporters." @default.
- W1520089072 created "2016-06-24" @default.
- W1520089072 creator A5006419045 @default.
- W1520089072 date "2011-11-15" @default.
- W1520089072 modified "2023-10-18" @default.
- W1520089072 title "The emerging physiological roles of the <i>SLC14A</i> family of urea transporters" @default.
- W1520089072 cites W1497054586 @default.
- W1520089072 cites W1563071499 @default.
- W1520089072 cites W1618643845 @default.
- W1520089072 cites W1947778485 @default.
- W1520089072 cites W1953206860 @default.
- W1520089072 cites W1956577119 @default.
- W1520089072 cites W1967156736 @default.
- W1520089072 cites W1968039412 @default.
- W1520089072 cites W1968553394 @default.
- W1520089072 cites W1970248517 @default.
- W1520089072 cites W1972946535 @default.
- W1520089072 cites W1974309534 @default.
- W1520089072 cites W1974504971 @default.
- W1520089072 cites W1974633406 @default.
- W1520089072 cites W1975794640 @default.
- W1520089072 cites W1978085375 @default.
- W1520089072 cites W1978915398 @default.
- W1520089072 cites W1983331685 @default.
- W1520089072 cites W1983398174 @default.
- W1520089072 cites W1983890412 @default.
- W1520089072 cites W1986903625 @default.
- W1520089072 cites W1987442187 @default.
- W1520089072 cites W1989648770 @default.
- W1520089072 cites W1991005002 @default.
- W1520089072 cites W1992439000 @default.
- W1520089072 cites W1994817672 @default.
- W1520089072 cites W1995046789 @default.
- W1520089072 cites W1996514841 @default.
- W1520089072 cites W1999664492 @default.
- W1520089072 cites W2000454415 @default.
- W1520089072 cites W2003010451 @default.
- W1520089072 cites W2008229348 @default.
- W1520089072 cites W2009036682 @default.
- W1520089072 cites W2012306119 @default.
- W1520089072 cites W2018894880 @default.
- W1520089072 cites W2020233709 @default.
- W1520089072 cites W2021112334 @default.
- W1520089072 cites W2021549898 @default.
- W1520089072 cites W2025293598 @default.
- W1520089072 cites W2025460399 @default.
- W1520089072 cites W2027936732 @default.
- W1520089072 cites W2034052118 @default.
- W1520089072 cites W2037216286 @default.
- W1520089072 cites W2038330463 @default.
- W1520089072 cites W2041613806 @default.
- W1520089072 cites W2042353170 @default.
- W1520089072 cites W2042889968 @default.
- W1520089072 cites W2044316778 @default.
- W1520089072 cites W2046873016 @default.
- W1520089072 cites W2050400976 @default.
- W1520089072 cites W2051660178 @default.
- W1520089072 cites W2051692813 @default.
- W1520089072 cites W2053147973 @default.
- W1520089072 cites W2055755743 @default.
- W1520089072 cites W2056693069 @default.
- W1520089072 cites W2059931404 @default.
- W1520089072 cites W2061346668 @default.
- W1520089072 cites W2063985437 @default.
- W1520089072 cites W2069600207 @default.
- W1520089072 cites W2072290830 @default.
- W1520089072 cites W2075396684 @default.
- W1520089072 cites W2077851978 @default.
- W1520089072 cites W2080823491 @default.
- W1520089072 cites W2084158810 @default.
- W1520089072 cites W2085021414 @default.
- W1520089072 cites W2085228708 @default.
- W1520089072 cites W2086370085 @default.
- W1520089072 cites W2087534198 @default.
- W1520089072 cites W2090211901 @default.
- W1520089072 cites W2090959453 @default.
- W1520089072 cites W2091386518 @default.
- W1520089072 cites W2092944093 @default.
- W1520089072 cites W2096574170 @default.
- W1520089072 cites W2097466966 @default.
- W1520089072 cites W2098779716 @default.
- W1520089072 cites W2104271112 @default.
- W1520089072 cites W2106666583 @default.
- W1520089072 cites W2108450175 @default.
- W1520089072 cites W2112360935 @default.
- W1520089072 cites W2112525791 @default.
- W1520089072 cites W2114078055 @default.
- W1520089072 cites W2115865774 @default.
- W1520089072 cites W2116293410 @default.
- W1520089072 cites W2118739443 @default.
- W1520089072 cites W2121011489 @default.
- W1520089072 cites W2122959376 @default.
- W1520089072 cites W2124784730 @default.
- W1520089072 cites W2126940957 @default.
- W1520089072 cites W2130913843 @default.
- W1520089072 cites W2131689711 @default.
- W1520089072 cites W2133036516 @default.
- W1520089072 cites W2135374199 @default.