FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520121301> ?p ?o ?g. }

• W1520121301 endingPage "363" @default.
• W1520121301 startingPage "356" @default.
• W1520121301 abstract "Fetal swallowing, digestion, and utilization of amniotic fluid protein were studied in near-term rhesus monkeys in which 35S-protein, synthesized biologically from 35S-methionine, was injected into the amniotic sac. The half-time of the injected protein in amniotic fluid was 1.1 days, a figure consistent with findings of others that fetal swallowing represents the principal mechanism of clearance of amniotic fluid protein. On delivery at timed intervals up to 7 days after injection, evidence of progressive proteolysis along the fetal alimentary tract was found. The amnio acids liberated from protein hydrolysis were apparently utilized in protein synthesis in the gut wall as well as absorbed in fetal plasma, where they equilibrated rapidly with maternal plasma and amniotic fluid. Maximal amino acid radioactivity in these three compartments occurred 3 days after injection and was followed 1 day later by maximal fetal plasma protein radioactivity. Incorporation into protein of amino acids absorbed after hydrolysis was found in fetal lung, liver, skeletal muscle, and brain. The results indicate that ingested amniotic fluid protein undergoes proteolysis in the fetal alimentary tract and the amino acids thus made available are utilized in protein synthesis by the developing fetus. While this mechanism can provide only a relatively minor proportion (estimated at 10 to 15 per cent) of fetal nitrogen requirements, it may represent an important aspect physiologically by preparing the fetus for extrauterine nutrition. Moreover, the use of intra-amniotic nutrition as a mode of fetal therafry, while speculative at present, offers possibilities for the future. Fetal swallowing, digestion, and utilization of amniotic fluid protein were studied in near-term rhesus monkeys in which 35S-protein, synthesized biologically from 35S-methionine, was injected into the amniotic sac. The half-time of the injected protein in amniotic fluid was 1.1 days, a figure consistent with findings of others that fetal swallowing represents the principal mechanism of clearance of amniotic fluid protein. On delivery at timed intervals up to 7 days after injection, evidence of progressive proteolysis along the fetal alimentary tract was found. The amnio acids liberated from protein hydrolysis were apparently utilized in protein synthesis in the gut wall as well as absorbed in fetal plasma, where they equilibrated rapidly with maternal plasma and amniotic fluid. Maximal amino acid radioactivity in these three compartments occurred 3 days after injection and was followed 1 day later by maximal fetal plasma protein radioactivity. Incorporation into protein of amino acids absorbed after hydrolysis was found in fetal lung, liver, skeletal muscle, and brain. The results indicate that ingested amniotic fluid protein undergoes proteolysis in the fetal alimentary tract and the amino acids thus made available are utilized in protein synthesis by the developing fetus. While this mechanism can provide only a relatively minor proportion (estimated at 10 to 15 per cent) of fetal nitrogen requirements, it may represent an important aspect physiologically by preparing the fetus for extrauterine nutrition. Moreover, the use of intra-amniotic nutrition as a mode of fetal therafry, while speculative at present, offers possibilities for the future." @default.
• W1520121301 created "2016-06-24" @default.
• W1520121301 creator A5025191931 @default.
• W1520121301 creator A5044226586 @default.
• W1520121301 date "1975-10-01" @default.
• W1520121301 modified "2023-09-26" @default.
• W1520121301 title "Fetal ingestion and metabolism of amniotic fluid protein" @default.
• W1520121301 cites W100479432 @default.
• W1520121301 cites W1503399743 @default.
• W1520121301 cites W1508924730 @default.
• W1520121301 cites W1599522515 @default.
• W1520121301 cites W1608872557 @default.
• W1520121301 cites W1718627217 @default.
• W1520121301 cites W1877614675 @default.
• W1520121301 cites W2019946385 @default.
• W1520121301 cites W2085228197 @default.
• W1520121301 cites W2093559290 @default.
• W1520121301 cites W2094885811 @default.
• W1520121301 cites W2399944985 @default.
• W1520121301 cites W2472067278 @default.
• W1520121301 doi "https://doi.org/10.1016/s0002-9378(16)33436-6" @default.
• W1520121301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/810026" @default.
• W1520121301 hasPublicationYear "1975" @default.
• W1520121301 type Work @default.
• W1520121301 sameAs 1520121301 @default.
• W1520121301 citedByCount "116" @default.
• W1520121301 countsByYear W15201213012012 @default.
• W1520121301 countsByYear W15201213012013 @default.
• W1520121301 countsByYear W15201213012014 @default.
• W1520121301 countsByYear W15201213012015 @default.
• W1520121301 countsByYear W15201213012016 @default.
• W1520121301 countsByYear W15201213012017 @default.
• W1520121301 countsByYear W15201213012018 @default.
• W1520121301 countsByYear W15201213012019 @default.
• W1520121301 countsByYear W15201213012021 @default.
• W1520121301 countsByYear W15201213012022 @default.
• W1520121301 crossrefType "journal-article" @default.
• W1520121301 hasAuthorship W1520121301A5025191931 @default.
• W1520121301 hasAuthorship W1520121301A5044226586 @default.
• W1520121301 hasConcept C126322002 @default.
• W1520121301 hasConcept C134018914 @default.
• W1520121301 hasConcept C16685009 @default.
• W1520121301 hasConcept C172680121 @default.
• W1520121301 hasConcept C181199279 @default.
• W1520121301 hasConcept C185592680 @default.
• W1520121301 hasConcept C2778194526 @default.
• W1520121301 hasConcept C2778261374 @default.
• W1520121301 hasConcept C2779234561 @default.
• W1520121301 hasConcept C2779572773 @default.
• W1520121301 hasConcept C2781307694 @default.
• W1520121301 hasConcept C515207424 @default.
• W1520121301 hasConcept C54355233 @default.
• W1520121301 hasConcept C55493867 @default.
• W1520121301 hasConcept C62231903 @default.
• W1520121301 hasConcept C71924100 @default.
• W1520121301 hasConcept C86803240 @default.
• W1520121301 hasConceptScore W1520121301C126322002 @default.
• W1520121301 hasConceptScore W1520121301C134018914 @default.
• W1520121301 hasConceptScore W1520121301C16685009 @default.
• W1520121301 hasConceptScore W1520121301C172680121 @default.
• W1520121301 hasConceptScore W1520121301C181199279 @default.
• W1520121301 hasConceptScore W1520121301C185592680 @default.
• W1520121301 hasConceptScore W1520121301C2778194526 @default.
• W1520121301 hasConceptScore W1520121301C2778261374 @default.
• W1520121301 hasConceptScore W1520121301C2779234561 @default.
• W1520121301 hasConceptScore W1520121301C2779572773 @default.
• W1520121301 hasConceptScore W1520121301C2781307694 @default.
• W1520121301 hasConceptScore W1520121301C515207424 @default.
• W1520121301 hasConceptScore W1520121301C54355233 @default.
• W1520121301 hasConceptScore W1520121301C55493867 @default.
• W1520121301 hasConceptScore W1520121301C62231903 @default.
• W1520121301 hasConceptScore W1520121301C71924100 @default.
• W1520121301 hasConceptScore W1520121301C86803240 @default.
• W1520121301 hasIssue "4" @default.
• W1520121301 hasLocation W15201213011 @default.
• W1520121301 hasLocation W15201213012 @default.
• W1520121301 hasOpenAccess W1520121301 @default.
• W1520121301 hasPrimaryLocation W15201213011 @default.
• W1520121301 hasRelatedWork W1520121301 @default.
• W1520121301 hasRelatedWork W1993795923 @default.
• W1520121301 hasRelatedWork W2052565638 @default.
• W1520121301 hasRelatedWork W2060936712 @default.
• W1520121301 hasRelatedWork W2080613476 @default.
• W1520121301 hasRelatedWork W2095329316 @default.
• W1520121301 hasRelatedWork W2114155978 @default.
• W1520121301 hasRelatedWork W2139232831 @default.
• W1520121301 hasRelatedWork W2141521254 @default.
• W1520121301 hasRelatedWork W50364286 @default.
• W1520121301 hasVolume "123" @default.
• W1520121301 isParatext "false" @default.
• W1520121301 isRetracted "false" @default.
• W1520121301 magId "1520121301" @default.
• W1520121301 workType "article" @default.