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• W152013658 abstract "The close association of human papillomavirus type 16 DNA with a majority of cervical carcinomas implies some role for the virus in this type of cancer. To define the transforming properties of HPV-16 DNA in vitro we have now performed transfection experiments on baby rat kidney cells using HPV-16 DNA in conjunction with an activated ras gene. We have demonstrated that a 6.6-kb DNA fragment, containing the early genes of HPV-16 under the control of Moloney murine leukaemia virus long terminal repeats (MoMuLV-LTRs), cooperates with EJ-ras in transforming these cells. Both DNAs are required and neither alone is effective. The cooperating activity appears to reside in a protein or proteins derived from the E6/E7 region of the HPV-16 genome." @default.
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• W152013658 date "1987-06-01" @default.
• W152013658 modified "2023-09-28" @default.
• W152013658 title "Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells." @default.
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• W152013658 doi "https://doi.org/10.1002/j.1460-2075.1987.tb02426.x" @default.
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