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- W1520161169 abstract "The chiral resolution of 3-thienylcyclohexylglycolic acid on a β-cyclodextrin-bonded chiral stationary phase (CSP) is described. A complete study was made of the influence of the organic solvent (nature and content) and phosphate buffer (pH and concentration) on retention, selectivity, efficiency and resolution and the effects of small structural changes to the solute on selectivity. The results allow a better understanding of retention and chiral recognition mechanisms. A model consistent with the fact that high retentions are observed in methanol in conjunction with the separation of enantiomers is proposed; it involves the degree of ionization of the solute in the mobile phase and in the liquid stationary phase. The separation of the methyl ester of 3-thienylcyclohexylglycolic acid cannot be achieved on Cyclobond-I CSP but is successful on ChiralCel OB CSP under both liquid and subcritical fluid chromatographic conditions. A comparison of these two analytical techniques is presented. 3-Thienylcyclohexylglycolic acid and its methyl ester are important reactants for the synthesis of new potent anticholinergic drugs." @default.
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- W1520161169 title "Chiral resolution of a series of 3-thienylcyclohexylglycolic acids by liquid or subcritical fluid chromatography" @default.
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