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- W1520200703 abstract "Gram-negative bacteria cause many types of infections in animals from fish and shrimps to humans. Bacteria use Type III secretion systems (TTSSs) to translocate their toxins directly into eukaryotic cells. The V-antigen is a multifunctional protein required for the TTSS in Yersinia and Pseudomonas aeruginosa. V-antigen vaccines and anti-V-antigen antisera confer protection against Yersinia or P. aeruginosa infections in animal models. The V-antigen forms a pentameric cap structure at the tip of the Type III secretory needle; this structure, which has evolved from the bacterial flagellar cap structure, is indispensable for toxin translocation. Various pathogenic gram-negative bacteria such as Photorhabdus luminescens, Vibrio spp., and Aeromonas spp. encode homologs of the V-antigen. Because the V-antigens of pathogenic gram-negative bacteria play a key role in toxin translocation, they are potential therapeutic targets for combatting bacterial virulence. In the USA and Europe, these vaccines and specific antibodies against V-antigens are in clinical trials investigating the treatment of Yersinia or P. aeruginosa infections. Pathogenic gram-negative bacteria are of great interest because of their ability to infect fish and shrimp farms, their potential for exploitation in biological terrorism attacks, and their ability to cause opportunistic infections in humans. Thus, elucidation of the roles of the V-antigen in the TTSS and mechanisms by which these functions can be blocked is critical to facilitating the development of improved anti-V-antigen strategies." @default.
- W1520200703 created "2016-06-24" @default.
- W1520200703 creator A5028936803 @default.
- W1520200703 creator A5031601538 @default.
- W1520200703 creator A5073108125 @default.
- W1520200703 date "2014-05-01" @default.
- W1520200703 modified "2023-09-26" @default.
- W1520200703 title "V-antigen homologs in pathogenic gram-negative bacteria" @default.
- W1520200703 cites W1480238212 @default.
- W1520200703 cites W1510065878 @default.
- W1520200703 cites W1511786918 @default.
- W1520200703 cites W1537283539 @default.
- W1520200703 cites W1551381812 @default.
- W1520200703 cites W1561147382 @default.
- W1520200703 cites W1571432809 @default.
- W1520200703 cites W1578975061 @default.
- W1520200703 cites W1619365252 @default.
- W1520200703 cites W1781659395 @default.
- W1520200703 cites W1821732051 @default.
- W1520200703 cites W1836556641 @default.
- W1520200703 cites W1847122693 @default.
- W1520200703 cites W1855676723 @default.
- W1520200703 cites W1866781827 @default.
- W1520200703 cites W1876103858 @default.
- W1520200703 cites W1883019490 @default.
- W1520200703 cites W1901875036 @default.
- W1520200703 cites W1915721517 @default.
- W1520200703 cites W1918587989 @default.
- W1520200703 cites W1923139939 @default.
- W1520200703 cites W1926393524 @default.
- W1520200703 cites W1935456639 @default.
- W1520200703 cites W1971654435 @default.
- W1520200703 cites W1973092868 @default.
- W1520200703 cites W1973680408 @default.
- W1520200703 cites W1976340579 @default.
- W1520200703 cites W1977764800 @default.
- W1520200703 cites W1978793659 @default.
- W1520200703 cites W1982890417 @default.
- W1520200703 cites W1983458029 @default.
- W1520200703 cites W1996239444 @default.
- W1520200703 cites W2003272265 @default.
- W1520200703 cites W2004668209 @default.
- W1520200703 cites W2007295060 @default.
- W1520200703 cites W2011417491 @default.
- W1520200703 cites W2019228627 @default.
- W1520200703 cites W2022873862 @default.
- W1520200703 cites W2023075328 @default.
- W1520200703 cites W2023091213 @default.
- W1520200703 cites W2024154104 @default.
- W1520200703 cites W2025184174 @default.
- W1520200703 cites W2027017334 @default.
- W1520200703 cites W2044074382 @default.
- W1520200703 cites W2056085992 @default.
- W1520200703 cites W2056186055 @default.
- W1520200703 cites W2056913982 @default.
- W1520200703 cites W2058145608 @default.
- W1520200703 cites W2058179337 @default.
- W1520200703 cites W2062106725 @default.
- W1520200703 cites W2066876605 @default.
- W1520200703 cites W2070736414 @default.
- W1520200703 cites W2071947177 @default.
- W1520200703 cites W2072381363 @default.
- W1520200703 cites W2072537229 @default.
- W1520200703 cites W2073723461 @default.
- W1520200703 cites W2074125670 @default.
- W1520200703 cites W2076833953 @default.
- W1520200703 cites W2090765750 @default.
- W1520200703 cites W2091346548 @default.
- W1520200703 cites W2093303713 @default.
- W1520200703 cites W2095710623 @default.
- W1520200703 cites W2096205447 @default.
- W1520200703 cites W2097099366 @default.
- W1520200703 cites W2098975839 @default.
- W1520200703 cites W2100693791 @default.
- W1520200703 cites W2101404732 @default.
- W1520200703 cites W2102804042 @default.
- W1520200703 cites W2104222407 @default.
- W1520200703 cites W2104503061 @default.
- W1520200703 cites W2106687873 @default.
- W1520200703 cites W2106811814 @default.
- W1520200703 cites W2107932853 @default.
- W1520200703 cites W2108829772 @default.
- W1520200703 cites W2109407177 @default.
- W1520200703 cites W2111340335 @default.
- W1520200703 cites W2111523341 @default.
- W1520200703 cites W2114314664 @default.
- W1520200703 cites W2115216196 @default.
- W1520200703 cites W2116361768 @default.
- W1520200703 cites W2118742923 @default.
- W1520200703 cites W2120339843 @default.
- W1520200703 cites W2120412245 @default.
- W1520200703 cites W2120826695 @default.
- W1520200703 cites W2121725999 @default.
- W1520200703 cites W2122845671 @default.
- W1520200703 cites W2123112413 @default.
- W1520200703 cites W2129087128 @default.
- W1520200703 cites W2129392320 @default.
- W1520200703 cites W2130110801 @default.