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• W1520216636 abstract "Six women and 6 men who were treated in double-blind fashion major depressive illness did not respond to imipramine or amitriptyline, 150-300 mg/day, during periods of 26-112 days. After the addition of 25 micrograms/day (10 patients) or 50 micrograms/day (2 patients) of L-triiodothyronine (T3), 9 patients showed statistically significant improvement in depression scores; in 8 patients the response was marked. Improvement generally began within 1-3 days and was noted in all aspects of the depressive syndrome; side effects were minimal. T3 did not change plasma levels of imipramine or desipramine or their ratio but did suppress serum thyroxine." @default.
• W1520216636 created "2016-06-24" @default.
• W1520216636 date "1982-01-01" @default.
• W1520216636 modified "2023-10-18" @default.
• W1520216636 title "Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders" @default.
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• W1520216636 doi "https://doi.org/10.1176/ajp.139.1.34" @default.
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