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• W1520223434 endingPage "10336" @default.
• W1520223434 startingPage "10331" @default.
• W1520223434 abstract "The interleukin-1 receptor antagonist (IL-1ra) is a protein capable of inhibiting receptor binding and biological activities of IL-1 without inducing an IL-1-like response. Equilibrium binding and kinetic experiments show that IL-1ra binds to the 80-kDa IL-1 receptor on the murine thymoma cell line EL4 with an affinity (KD = 150 pM) approximately equal to that of IL-1 alpha and IL-1 beta for this receptor. However, IL-1ra is unable to induce two early events associated with IL-1 activity. Surface-bound IL-1ra does not undergo receptor-mediated internalization, and IL-1ra does not activate the protein kinase activity responsible for down-modulation of the EGF receptor on the murine 3T3 fibroblast cell line. The failure to induce general, early responses characteristic of IL-1 indicates that IL-1ra is unlikely to act as an agonist on any cell expressing the 80-kDa receptor." @default.
• W1520223434 created "2016-06-24" @default.
• W1520223434 creator A5015825916 @default.
• W1520223434 creator A5034167482 @default.
• W1520223434 creator A5055956388 @default.
• W1520223434 creator A5058527628 @default.
• W1520223434 date "1991-06-01" @default.
• W1520223434 modified "2023-10-18" @default.
• W1520223434 title "Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction" @default.
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• W1520223434 doi "https://doi.org/10.1016/s0021-9258(18)99230-6" @default.
• W1520223434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1828071" @default.
• W1520223434 hasPublicationYear "1991" @default.
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