Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520255941> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1520255941 endingPage "67" @default.
- W1520255941 startingPage "61" @default.
- W1520255941 abstract "Sunitinib and sorafenib are small-molecule tyrosine kinase inhibitors (TKI) with antitumor activity in advanced renal cell carcinoma. A retrospective study was conducted to assess the response of renal cell carcinoma to sequential treatment with these two agents.Tumor response was evaluated by using Response Evaluation Criteria In Solid Tumors (RECIST) criteria in patients failing first-line therapy with either sunitinib or sorafenib and subsequently receiving second-line therapy with the other TKI agent.Twenty-nine patients received sorafenib followed by sunitinib (Group A), and 20 patients received sunitinib followed by sorafenib (Group B). TKI drugs were terminated in 6 (12%) patients in Group A and 4 (8%) in Group B because of toxicity. Median duration of stable disease for Groups A and B was 20 and 9.5 weeks, respectively. Median time from starting first TKI to disease progression after second TKI (time to progression) in Groups A and B was 78 and 37 weeks, respectively. Multivariate analysis revealed that Group B had a shorter time to progression than Group A (risk ratio [RR] 3.0; P=.016). Median overall survival was 102 and 45 weeks in Groups A and B, respectively (P=.061).The longer duration of disease control in patients who received sorafenib followed by sunitinib warrants further investigation." @default.
- W1520255941 created "2016-06-24" @default.
- W1520255941 creator A5004376320 @default.
- W1520255941 creator A5029696964 @default.
- W1520255941 creator A5049048398 @default.
- W1520255941 creator A5082073847 @default.
- W1520255941 creator A5090069473 @default.
- W1520255941 date "2008-12-02" @default.
- W1520255941 modified "2023-10-14" @default.
- W1520255941 title "Sequential therapy with sorafenib and sunitinib in renal cell carcinoma" @default.
- W1520255941 cites W1999966467 @default.
- W1520255941 cites W2075997152 @default.
- W1520255941 cites W2078449820 @default.
- W1520255941 cites W2118677643 @default.
- W1520255941 cites W2127786249 @default.
- W1520255941 cites W2140765540 @default.
- W1520255941 cites W2143813821 @default.
- W1520255941 cites W2149456801 @default.
- W1520255941 cites W2156408558 @default.
- W1520255941 doi "https://doi.org/10.1002/cncr.24009" @default.
- W1520255941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19051290" @default.
- W1520255941 hasPublicationYear "2008" @default.
- W1520255941 type Work @default.
- W1520255941 sameAs 1520255941 @default.
- W1520255941 citedByCount "164" @default.
- W1520255941 countsByYear W15202559412012 @default.
- W1520255941 countsByYear W15202559412013 @default.
- W1520255941 countsByYear W15202559412014 @default.
- W1520255941 countsByYear W15202559412015 @default.
- W1520255941 countsByYear W15202559412016 @default.
- W1520255941 countsByYear W15202559412017 @default.
- W1520255941 countsByYear W15202559412018 @default.
- W1520255941 countsByYear W15202559412019 @default.
- W1520255941 countsByYear W15202559412020 @default.
- W1520255941 countsByYear W15202559412021 @default.
- W1520255941 countsByYear W15202559412022 @default.
- W1520255941 crossrefType "journal-article" @default.
- W1520255941 hasAuthorship W1520255941A5004376320 @default.
- W1520255941 hasAuthorship W1520255941A5029696964 @default.
- W1520255941 hasAuthorship W1520255941A5049048398 @default.
- W1520255941 hasAuthorship W1520255941A5082073847 @default.
- W1520255941 hasAuthorship W1520255941A5090069473 @default.
- W1520255941 hasConcept C121608353 @default.
- W1520255941 hasConcept C126322002 @default.
- W1520255941 hasConcept C126894567 @default.
- W1520255941 hasConcept C143998085 @default.
- W1520255941 hasConcept C2777472916 @default.
- W1520255941 hasConcept C2778019345 @default.
- W1520255941 hasConcept C2778695046 @default.
- W1520255941 hasConcept C2778820342 @default.
- W1520255941 hasConcept C2778822529 @default.
- W1520255941 hasConcept C2779134260 @default.
- W1520255941 hasConcept C2779490328 @default.
- W1520255941 hasConcept C2779984678 @default.
- W1520255941 hasConcept C71924100 @default.
- W1520255941 hasConcept C90924648 @default.
- W1520255941 hasConceptScore W1520255941C121608353 @default.
- W1520255941 hasConceptScore W1520255941C126322002 @default.
- W1520255941 hasConceptScore W1520255941C126894567 @default.
- W1520255941 hasConceptScore W1520255941C143998085 @default.
- W1520255941 hasConceptScore W1520255941C2777472916 @default.
- W1520255941 hasConceptScore W1520255941C2778019345 @default.
- W1520255941 hasConceptScore W1520255941C2778695046 @default.
- W1520255941 hasConceptScore W1520255941C2778820342 @default.
- W1520255941 hasConceptScore W1520255941C2778822529 @default.
- W1520255941 hasConceptScore W1520255941C2779134260 @default.
- W1520255941 hasConceptScore W1520255941C2779490328 @default.
- W1520255941 hasConceptScore W1520255941C2779984678 @default.
- W1520255941 hasConceptScore W1520255941C71924100 @default.
- W1520255941 hasConceptScore W1520255941C90924648 @default.
- W1520255941 hasIssue "1" @default.
- W1520255941 hasLocation W15202559411 @default.
- W1520255941 hasLocation W15202559412 @default.
- W1520255941 hasOpenAccess W1520255941 @default.
- W1520255941 hasPrimaryLocation W15202559411 @default.
- W1520255941 hasRelatedWork W1498185347 @default.
- W1520255941 hasRelatedWork W1520255941 @default.
- W1520255941 hasRelatedWork W2005831962 @default.
- W1520255941 hasRelatedWork W2030884865 @default.
- W1520255941 hasRelatedWork W2070019048 @default.
- W1520255941 hasRelatedWork W2110720470 @default.
- W1520255941 hasRelatedWork W2135916881 @default.
- W1520255941 hasRelatedWork W2400004468 @default.
- W1520255941 hasRelatedWork W2590105029 @default.
- W1520255941 hasRelatedWork W2913140451 @default.
- W1520255941 hasVolume "115" @default.
- W1520255941 isParatext "false" @default.
- W1520255941 isRetracted "false" @default.
- W1520255941 magId "1520255941" @default.
- W1520255941 workType "article" @default.