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- W1520282948 endingPage "956" @default.
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- W1520282948 abstract "The bovine papillomavirus type 1 (BPV-1) E2 open reading frame encodes three proteins: the E2 transcriptional transactivator, the E2 transcriptional repressor (E2-TR), and the E8/E2 fusion peptide. In this study, we describe the phenotypes of BPV-1 mutants which are disrupted in their capacity to encode either the E2 transcriptional repressor or the E8/E2 fusion peptide. We also describe experiments which demonstrate that the E8/E2 gene product functions similarly to E2-TR. In the context of the entire viral genome, disruption of E8/E2 expression had little effect on viral processes, whereas disruption of E2-TR expression resulted in a complex phenotype marked by a 10- to 20-fold increase in viral DNA plasmid copy number as well as increased transformation potential. A double mutant, defective in the expression of both E8/E2 and E2-TR proteins, had high levels of E2 transactivation activity yet had reduced plasmid replication capacity and a delayed capacity to transform rodent cells." @default.
- W1520282948 created "2016-06-24" @default.
- W1520282948 creator A5015582793 @default.
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- W1520282948 date "1990-02-01" @default.
- W1520282948 modified "2023-10-14" @default.
- W1520282948 title "Phenotypic analysis of bovine papillomavirus type 1 E2 repressor mutants" @default.
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- W1520282948 doi "https://doi.org/10.1128/jvi.64.2.950-956.1990" @default.
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