Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520283315> ?p ?o ?g. }
- W1520283315 endingPage "11" @default.
- W1520283315 startingPage "1" @default.
- W1520283315 abstract "Tumor suppressor functions are essential to control cellular proliferation, to activate the apoptosis or senescence pathway to eliminate unwanted cells, to link DNA damage signals to cell cycle arrest checkpoints, to activate appropriate DNA repair pathways, and to prevent the loss of adhesion to inhibit initiation of metastases. Therefore, tumor suppressor genes are indispensable to maintaining genetic and genomic integrity. Consequently, inactivation of tumor suppressors by somatic mutations or epigenetic mechanisms is frequently associated with tumor initiation and development. In contrast, reactivation of tumor suppressor functions can effectively reverse the transformed phenotype and lead to cell cycle arrest or death of cancerous cells and be used as a therapeutic strategy. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative disease associated with infection of CD4 T cells by the Human T-cell Leukemia Virus Type 1 (HTLV-I). HTLV-I-associated T-cell transformation is the result of a multistep oncogenic process in which the virus initially induces chronic T-cell proliferation and alters cellular pathways resulting in the accumulation of genetic defects and the deregulated growth of virally infected cells. This review will focus on the current knowledge of the genetic and epigenetic mechanisms regulating the inactivation of tumor suppressors in the pathogenesis of HTLV-I." @default.
- W1520283315 created "2016-06-24" @default.
- W1520283315 creator A5025054085 @default.
- W1520283315 date "2015-01-01" @default.
- W1520283315 modified "2023-09-23" @default.
- W1520283315 title "Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia" @default.
- W1520283315 cites W1284489 @default.
- W1520283315 cites W132194344 @default.
- W1520283315 cites W1521196748 @default.
- W1520283315 cites W1542367364 @default.
- W1520283315 cites W1573652663 @default.
- W1520283315 cites W1602356478 @default.
- W1520283315 cites W17654226 @default.
- W1520283315 cites W1964352720 @default.
- W1520283315 cites W1965912619 @default.
- W1520283315 cites W1970000478 @default.
- W1520283315 cites W1972822397 @default.
- W1520283315 cites W1972849875 @default.
- W1520283315 cites W1974102799 @default.
- W1520283315 cites W1974138460 @default.
- W1520283315 cites W1974466602 @default.
- W1520283315 cites W1975026942 @default.
- W1520283315 cites W1979123591 @default.
- W1520283315 cites W1979413046 @default.
- W1520283315 cites W1981836992 @default.
- W1520283315 cites W1984029522 @default.
- W1520283315 cites W1985064409 @default.
- W1520283315 cites W1985146880 @default.
- W1520283315 cites W1985537894 @default.
- W1520283315 cites W1985605693 @default.
- W1520283315 cites W1986914857 @default.
- W1520283315 cites W1994798501 @default.
- W1520283315 cites W1996165735 @default.
- W1520283315 cites W1996222881 @default.
- W1520283315 cites W1997733907 @default.
- W1520283315 cites W1998528913 @default.
- W1520283315 cites W1999706014 @default.
- W1520283315 cites W2007919305 @default.
- W1520283315 cites W2008033547 @default.
- W1520283315 cites W2008383971 @default.
- W1520283315 cites W2009621572 @default.
- W1520283315 cites W2010400502 @default.
- W1520283315 cites W2010958617 @default.
- W1520283315 cites W2012758718 @default.
- W1520283315 cites W2015018301 @default.
- W1520283315 cites W2015352009 @default.
- W1520283315 cites W2015519364 @default.
- W1520283315 cites W2016246425 @default.
- W1520283315 cites W2016534065 @default.
- W1520283315 cites W2019871537 @default.
- W1520283315 cites W2021348938 @default.
- W1520283315 cites W2024034767 @default.
- W1520283315 cites W2024348913 @default.
- W1520283315 cites W2028624655 @default.
- W1520283315 cites W2034564751 @default.
- W1520283315 cites W2035673858 @default.
- W1520283315 cites W2036307706 @default.
- W1520283315 cites W2038982713 @default.
- W1520283315 cites W2041827979 @default.
- W1520283315 cites W2042920587 @default.
- W1520283315 cites W2043248836 @default.
- W1520283315 cites W2043619249 @default.
- W1520283315 cites W2045016873 @default.
- W1520283315 cites W2045364645 @default.
- W1520283315 cites W2046577405 @default.
- W1520283315 cites W2052017753 @default.
- W1520283315 cites W2053747212 @default.
- W1520283315 cites W2054549064 @default.
- W1520283315 cites W2054682263 @default.
- W1520283315 cites W2055085859 @default.
- W1520283315 cites W2055239477 @default.
- W1520283315 cites W2057132217 @default.
- W1520283315 cites W2058924545 @default.
- W1520283315 cites W2059515487 @default.
- W1520283315 cites W2060459012 @default.
- W1520283315 cites W2067973442 @default.
- W1520283315 cites W2068345721 @default.
- W1520283315 cites W2068909560 @default.
- W1520283315 cites W2069443586 @default.
- W1520283315 cites W2069526622 @default.
- W1520283315 cites W2070249425 @default.
- W1520283315 cites W2070854644 @default.
- W1520283315 cites W2070937423 @default.
- W1520283315 cites W2071592765 @default.
- W1520283315 cites W2071794490 @default.
- W1520283315 cites W2075300416 @default.
- W1520283315 cites W2076062398 @default.
- W1520283315 cites W2080077392 @default.
- W1520283315 cites W2080411938 @default.
- W1520283315 cites W2082306756 @default.
- W1520283315 cites W2082738737 @default.
- W1520283315 cites W2083274386 @default.
- W1520283315 cites W2086143621 @default.
- W1520283315 cites W2090457563 @default.
- W1520283315 cites W2090533075 @default.
- W1520283315 cites W2091338477 @default.
- W1520283315 cites W2092174482 @default.
- W1520283315 cites W2093015940 @default.