FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520287552> ?p ?o ?g. }

• W1520287552 abstract "Purpose: The blockade of allograft rejection is essential to a successful pancreatic islet (PI) transplantation. An attractive alternative arises from the immunological paradox during pregnancy, when the mother does not reject the allogeneic fetus. This protection may be due to the IDO production in the placenta. Purpose: To isolate the IDO cDNA, to construct a vector expression for IDO and to analyze the effect of the IDO expression into PI in an experimental model of PI transplantation. Methods: The IDO cDNA was isolated from rat placenta and inserted in the pcDNA 3.1 vector. PI were transfected using Lipofectamine and different concentrations of the IDO-vector were analyzed. The IDO expression was confirmed by RT-PCR, immunohistochemistry and functional analysis. Lewis rats with streptozotocin-induced diabetes (glycemia >300mg/dL) received islets under the kidney capsule and they were distributed among groups: SYN Tx (syngeneic), Lewis recipients transplanted with islets from Lewis rats; ALLO Tx (allogeneic), Lewis recipients of islets from Sprague-Dawley rats; and ALLO+IDO Tx, Lewis recipients of IDO-transfected islets from Sprague-Dawley rats. Results: The SYN Tx rats presented permanent normoglycemia, while the ALLO Tx rats returned to hyperglycemia (>300mg/dl) few days after transplantation (11+1 days). In contrast, ALLO+IDO Tx rats presented glycemia <300mg/dL during a longer-term follow-up. At day 45, the SYN Tx group presented normal levels of serum insulin (0.55+0.13 ng/mL), while the ALLO Tx group presented a significantly reduction (0.14+0.02 ng/mL; p<0.05). The ALLO+IDO Tx group presented significantly higher levels than the ALLO Tx group (0.33+0.04 ng/mL;p<0.05). Conclusion: The induction of IDO expression protects the islets, increasing islets survival and improving the metabolic control." @default.
• W1520287552 created "2016-06-24" @default.
• W1520287552 creator A5011047808 @default.
• W1520287552 date "2015-10-21" @default.
• W1520287552 modified "2023-09-27" @default.
• W1520287552 title "Indução da expressão da molécula indoleamina 2,3-dioxigenase (IDO) como terapia gênica em transplante experimental de ilhotas pancreáticas" @default.
• W1520287552 cites W121794252 @default.
• W1520287552 cites W1543695295 @default.
• W1520287552 cites W1597339327 @default.
• W1520287552 cites W1892959235 @default.
• W1520287552 cites W1963540911 @default.
• W1520287552 cites W1964150730 @default.
• W1520287552 cites W1965644358 @default.
• W1520287552 cites W1974401900 @default.
• W1520287552 cites W1978138910 @default.
• W1520287552 cites W1983113619 @default.
• W1520287552 cites W1986169709 @default.
• W1520287552 cites W1989496524 @default.
• W1520287552 cites W1993693624 @default.
• W1520287552 cites W1994233043 @default.
• W1520287552 cites W1994478809 @default.
• W1520287552 cites W1995808451 @default.
• W1520287552 cites W1997916553 @default.
• W1520287552 cites W2000938716 @default.
• W1520287552 cites W2004806121 @default.
• W1520287552 cites W2006693847 @default.
• W1520287552 cites W2006919788 @default.
• W1520287552 cites W2012505860 @default.
• W1520287552 cites W2015260577 @default.
• W1520287552 cites W2020267609 @default.
• W1520287552 cites W2022121727 @default.
• W1520287552 cites W2022430924 @default.
• W1520287552 cites W2025061457 @default.
• W1520287552 cites W2026610346 @default.
• W1520287552 cites W2027735697 @default.
• W1520287552 cites W2029820788 @default.
• W1520287552 cites W2031953196 @default.
• W1520287552 cites W2035010412 @default.
• W1520287552 cites W2035693222 @default.
• W1520287552 cites W2037190164 @default.
• W1520287552 cites W2037520549 @default.
• W1520287552 cites W2037920661 @default.
• W1520287552 cites W2044601416 @default.
• W1520287552 cites W2046436291 @default.
• W1520287552 cites W2048630527 @default.
• W1520287552 cites W2055227797 @default.
• W1520287552 cites W2055913203 @default.
• W1520287552 cites W2058441058 @default.
• W1520287552 cites W2060325363 @default.
• W1520287552 cites W2060485137 @default.
• W1520287552 cites W2061009859 @default.
• W1520287552 cites W2063144795 @default.
• W1520287552 cites W2064452632 @default.
• W1520287552 cites W2066503227 @default.
• W1520287552 cites W2067133169 @default.
• W1520287552 cites W2072078248 @default.
• W1520287552 cites W2077612514 @default.
• W1520287552 cites W2077772833 @default.
• W1520287552 cites W2080114015 @default.
• W1520287552 cites W2080187002 @default.
• W1520287552 cites W2082694978 @default.
• W1520287552 cites W2086002861 @default.
• W1520287552 cites W2086935573 @default.
• W1520287552 cites W2087175644 @default.
• W1520287552 cites W2100215924 @default.
• W1520287552 cites W2116348979 @default.
• W1520287552 cites W2116460986 @default.
• W1520287552 cites W2118929543 @default.
• W1520287552 cites W2124282832 @default.
• W1520287552 cites W2127857033 @default.
• W1520287552 cites W2135573771 @default.
• W1520287552 cites W2135616795 @default.
• W1520287552 cites W2145330496 @default.
• W1520287552 cites W2145467687 @default.
• W1520287552 cites W2148452017 @default.
• W1520287552 cites W2149036744 @default.
• W1520287552 cites W2151716122 @default.
• W1520287552 cites W2154394276 @default.
• W1520287552 cites W2156119419 @default.
• W1520287552 cites W2157865424 @default.
• W1520287552 cites W2160827995 @default.
• W1520287552 cites W2167897482 @default.
• W1520287552 cites W2312871938 @default.
• W1520287552 cites W2328786770 @default.
• W1520287552 cites W2397932510 @default.
• W1520287552 cites W2408097917 @default.
• W1520287552 cites W2411835254 @default.
• W1520287552 cites W2412501478 @default.
• W1520287552 cites W2413888881 @default.
• W1520287552 cites W2415298925 @default.
• W1520287552 doi "https://doi.org/10.11606/t.5.2007.tde-11092007-133551" @default.
• W1520287552 hasPublicationYear "2015" @default.
• W1520287552 type Work @default.
• W1520287552 sameAs 1520287552 @default.
• W1520287552 citedByCount "0" @default.
• W1520287552 crossrefType "dissertation" @default.
• W1520287552 hasAuthorship W1520287552A5011047808 @default.
• W1520287552 hasBestOaLocation W15202875521 @default.
• W1520287552 hasConcept C126322002 @default.
• W1520287552 hasConcept C134018914 @default.

• next