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- W1520295936 abstract "Rabbit lymph node cells (Ig+Ig−) were rosetted with anti-Ig antibody-coated erythrocytes and the rosetted Ig+ cells (B cells) were separated from unrosetted Ig− cells (T cells) by centrifugation through Ficoll-Hypaque medium. The Ig− cells were recovered from the top and the Ig+ cells from the bottom of the Ficoll-Hypaque layer. Some of the purified Ig+ cells lost their ability to form rosettes when cultured with the mitogen associated with streptolysin O. This suggested that the Ig+ population might contain two distinct subpopulations. The response of Ig+Ig−, Ig+, and Ig− cells to various mitogens was studied. The Ig− cells incorporated more 3H-TdR when they were incubated by themselves than when they were cultured with Ig+ cells in an Ig+Ig− culture. On the other hand, the Ig+ cells incorporated less 3H-TdR when they were incubated by themselves than when they were incubated with Ig− cells in an Ig+Ig− culture. Thus, Ig+ cells suppressed the response of Ig− cells whereas Ig− cells enhanced the response of Ig+ cells. We conclude that rabbit Ig+ cells (B cells) and Ig− cells (T cells) interact with a feedback pattern of regulation." @default.
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- W1520295936 date "1976-03-01" @default.
- W1520295936 modified "2023-09-27" @default.
- W1520295936 title "Rabbit lymphocyte subpopulations" @default.
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- W1520295936 doi "https://doi.org/10.1016/0008-8749(76)90007-1" @default.
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