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• W1520296952 abstract "Abstract Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that results in muscle weakness and atrophy. To attenuate disease severity, drug development studies have been applied mainly to target the Survival of Motor Neuron 2 (SMN2) gene, which is an important modifier of SMA. Although several compounds have been tested, there is still no cure for SMA. In this study, SMN2‐inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients. Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level." @default.
• W1520296952 created "2016-06-24" @default.
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• W1520296952 date "2014-11-11" @default.
• W1520296952 modified "2023-09-23" @default.
• W1520296952 title "Effects of flavonoid quercetin on survival of motor neuron gene expression" @default.
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• W1520296952 doi "https://doi.org/10.1002/cbin.10395" @default.
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