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- W1520303385 endingPage "2033" @default.
- W1520303385 startingPage "2017" @default.
- W1520303385 abstract "Given the role of type II protein secretion system (T2S) in the ecology and pathogenesis of Legionella pneumophila, it is possible that this system is a target for adaptive evolution. The population genetic structure of L.pneumophila was inferred from the partial sequences of rpoB and from the complete sequence of three T2S structural components (lspD, lspE and pilD) and from two T2S effectors critical for intracellular infection of protozoa (proA and srnA) of 37 strains isolated from natural and man-made environments and disease-related from worldwide sources. A phylogenetic analysis was obtained for the concatenated alignment and for each individual locus. Seven main groups were identified containing the same L.pneumophila strains, suggesting an ancient divergence for each cluster and indicating that the operating selective pressures have equally affected the evolution of the five genes. Although linkage disequilibrium analysis indicate a clonal nature for population structure in this sample, our results indicate that recombination is a common phenomenon among T2S-related genes on this species, as 24 of the 37 L.pneumophila isolates contained at least one locus in which recombination was identified. Furthermore, neutral selection acting on the analysed T2S-related genes emerged as a clear result, namely on T2S effectors, ProA and SrnA, indicating that they are probably implicated in conserved virulence mechanisms through legionellae hosts." @default.
- W1520303385 created "2016-06-24" @default.
- W1520303385 creator A5049776174 @default.
- W1520303385 creator A5064503059 @default.
- W1520303385 creator A5075007475 @default.
- W1520303385 creator A5086778472 @default.
- W1520303385 date "2011-11-28" @default.
- W1520303385 modified "2023-09-25" @default.
- W1520303385 title "Molecular evolution of key genes for type II secretion in Legionella pneumophila" @default.
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- W1520303385 doi "https://doi.org/10.1111/j.1462-2920.2011.02646.x" @default.
- W1520303385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22118294" @default.