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• W1520335425 abstract "The risk of deep vein thrombosis (DVT) is increased in cancer patients with central venous catheters (CVC). Factor (F)V Leiden and the G20210A prothrombin mutation (PTM) may play a role in causing catheter-related DVT in patients with cancer. However, information on the association between these thrombophilic abnormalities and CVC-related thrombosis are scarce.To assess the risk of CVC-related thrombosis associated with these two thrombophilic disorders.MEDLINE and EMBASE databases (up to March 2007); reference lists of retrieved articles. Studies comparing the prevalence of prothrombotic abnormalities in cancer patients with CVC-related thrombosis and in a control group of cancer subjects with CVC without thrombosis. Two reviewers independently selected studies and extracted study characteristics, quality and outcomes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each trial and pooled.Ten studies involving 1000 patients were included. The pooled OR for CVC-related thrombosis was 4.6 (95% CI: 2.6, 8.1) in patients with FV Leiden. The pooled OR for CVC-related thrombosis was 4.9 (95% CI: 1.7, 14.3) in patients with PTM. The estimated attributable risk of CVC-related thrombosis was 13.1% for FV Leiden and 4.5% for PTM.Our meta-analysis suggests that the presence of FV Leiden and PTM is associated with CVC-related thrombosis." @default.
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• W1520335425 date "2008-01-01" @default.
• W1520335425 modified "2023-09-30" @default.
• W1520335425 title "Association between inherited thrombophilic abnormalities and central venous catheter thrombosis in patients with cancer: a meta‐analysis" @default.
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• W1520335425 doi "https://doi.org/10.1111/j.1538-7836.2007.02823.x" @default.
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