Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520347430> ?p ?o ?g. }
- W1520347430 endingPage "6405" @default.
- W1520347430 startingPage "6394" @default.
- W1520347430 abstract "Abstract Cmv1 was the first mouse cytomegalovirus (MCMV) resistance locus identified in C57BL/6 mice. It encodes Ly49H, a NK cell-activating receptor that specifically recognizes the m157 viral protein at the surface of MCMV-infected cells. To dissect the effect of the Ly49h gene in host-pathogen interactions, we generated C57BL/6 mice lacking the Ly49h region. We found that 36 h after MCMV infection, the lack of Ly49h resulted in high viral replication in the spleen and dramatically enhanced proinflammatory cytokine production in the serum and spleen. At later points in time, we observed that MCMV induced a drastic loss in CD8+ T cells in B6.Ly49h−/− mice, probably reflecting severe histological changes in the spleen. Overall, our results indicate that Ly49H+ NK cells contain a systemic production of cytokines that may contribute to the MCMV-induced pathology and play a central role in maintaining normal spleen cell microarchitecture. Finally, we tested the ability of B6.Ly49h−/− mice to control replication of Leishmania major and ectromelia virus. Resistance to these pathogens has been previously mapped within the NK gene complex. We found that the lack of Ly49H+ NK cells is not associated with an altered resistance to L. major. In contrast, absence of Ly49H+ NK cells seems to afford additional protection against ectromelia infection in C57BL/6 mice, suggesting that Ly49H may recognize ectromelia-infected cells with detrimental effects. Taken together, these results confirm the pivotal role of the Ly49H receptor during MCMV infection and open the way for further investigations in host-pathogen interactions." @default.
- W1520347430 created "2016-06-24" @default.
- W1520347430 creator A5014245073 @default.
- W1520347430 creator A5021307048 @default.
- W1520347430 creator A5046304077 @default.
- W1520347430 creator A5054475023 @default.
- W1520347430 creator A5057257626 @default.
- W1520347430 creator A5082274877 @default.
- W1520347430 creator A5089513785 @default.
- W1520347430 date "2008-11-01" @default.
- W1520347430 modified "2023-10-03" @default.
- W1520347430 title "<i>Ly49h</i>-Deficient C57BL/6 Mice: A New Mouse Cytomegalovirus-Susceptible Model Remains Resistant to Unrelated Pathogens Controlled by the NK Gene Complex" @default.
- W1520347430 cites W1495443035 @default.
- W1520347430 cites W1495950501 @default.
- W1520347430 cites W1506441972 @default.
- W1520347430 cites W1524823709 @default.
- W1520347430 cites W1567093690 @default.
- W1520347430 cites W1580179014 @default.
- W1520347430 cites W1582201252 @default.
- W1520347430 cites W1616163779 @default.
- W1520347430 cites W1642318346 @default.
- W1520347430 cites W1673406593 @default.
- W1520347430 cites W1749209363 @default.
- W1520347430 cites W1820258609 @default.
- W1520347430 cites W182226002 @default.
- W1520347430 cites W1850794279 @default.
- W1520347430 cites W1953821950 @default.
- W1520347430 cites W1961385456 @default.
- W1520347430 cites W1966280572 @default.
- W1520347430 cites W1969209186 @default.
- W1520347430 cites W1971583765 @default.
- W1520347430 cites W1978275869 @default.
- W1520347430 cites W1980349196 @default.
- W1520347430 cites W1981519046 @default.
- W1520347430 cites W1995705318 @default.
- W1520347430 cites W1999199838 @default.
- W1520347430 cites W1999355254 @default.
- W1520347430 cites W2000769786 @default.
- W1520347430 cites W2003565653 @default.
- W1520347430 cites W2003568672 @default.
- W1520347430 cites W2003750466 @default.
- W1520347430 cites W2008221423 @default.
- W1520347430 cites W2016208474 @default.
- W1520347430 cites W2022273444 @default.
- W1520347430 cites W2022678668 @default.
- W1520347430 cites W2027139443 @default.
- W1520347430 cites W2035546749 @default.
- W1520347430 cites W2039449244 @default.
- W1520347430 cites W2042728577 @default.
- W1520347430 cites W2049678425 @default.
- W1520347430 cites W2053379561 @default.
- W1520347430 cites W2057127638 @default.
- W1520347430 cites W2061049446 @default.
- W1520347430 cites W2062353391 @default.
- W1520347430 cites W2067300584 @default.
- W1520347430 cites W2067937110 @default.
- W1520347430 cites W2074366035 @default.
- W1520347430 cites W2087868059 @default.
- W1520347430 cites W2088273900 @default.
- W1520347430 cites W2088527057 @default.
- W1520347430 cites W2091943843 @default.
- W1520347430 cites W2092490738 @default.
- W1520347430 cites W2095548329 @default.
- W1520347430 cites W2096231594 @default.
- W1520347430 cites W2096726255 @default.
- W1520347430 cites W2099662728 @default.
- W1520347430 cites W2108548328 @default.
- W1520347430 cites W2110342824 @default.
- W1520347430 cites W2110864354 @default.
- W1520347430 cites W2110868166 @default.
- W1520347430 cites W2110988104 @default.
- W1520347430 cites W2112278838 @default.
- W1520347430 cites W2114755573 @default.
- W1520347430 cites W2116120252 @default.
- W1520347430 cites W2120290188 @default.
- W1520347430 cites W2121106702 @default.
- W1520347430 cites W2122797744 @default.
- W1520347430 cites W2122822209 @default.
- W1520347430 cites W2125128634 @default.
- W1520347430 cites W2125589480 @default.
- W1520347430 cites W2132282141 @default.
- W1520347430 cites W2132507383 @default.
- W1520347430 cites W2132898771 @default.
- W1520347430 cites W2135174210 @default.
- W1520347430 cites W2136281115 @default.
- W1520347430 cites W2143970355 @default.
- W1520347430 cites W2145558217 @default.
- W1520347430 cites W2145965012 @default.
- W1520347430 cites W2146261880 @default.
- W1520347430 cites W2146733498 @default.
- W1520347430 cites W2153455757 @default.
- W1520347430 cites W2158257167 @default.
- W1520347430 cites W2161027033 @default.
- W1520347430 cites W2166807496 @default.
- W1520347430 cites W2168282353 @default.
- W1520347430 cites W2170536698 @default.
- W1520347430 cites W2171306408 @default.
- W1520347430 cites W2171795801 @default.