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- W1520358010 abstract "Abstract Thymic stromal lymphopoietin (TSLP) is an epithelial cell derived cytokine important for the initiation and development of Th2-mediated allergic inflammation. In this study, we identified a significant association between IL-9 and TSLP concentration in the serum of infants with atopic dermatitis. Th9 cultures increased IL-9 production in a TSLP dose-dependent manner, parallel with an increase in pSTAT5 binding to Il9, Irf4 and Gata3 loci. Lung-specific transgenic expression of TSLP stimulated IL-9 production in the lung, and anti-IL-9 treatment attenuated TSLP-induced airway inflammation. Using an adoptive transfer model, we observed that TSLP promoted Th9-induced allergic inflammation in an IL-9-dependent manner, with affects directly on T cells. Together, our results demonstrate that TSLP promotes Th9 differentiation, and define a requirement for IL-9 in TSLP-induced allergic inflammation." @default.
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- W1520358010 date "2012-05-01" @default.
- W1520358010 modified "2023-09-23" @default.
- W1520358010 title "IL-9 is Required for TSLP-mediated Allergic Airway Inflammation (64.3)" @default.
- W1520358010 doi "https://doi.org/10.4049/jimmunol.188.supp.64.3" @default.
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