FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520363931> ?p ?o ?g. }

• W1520363931 endingPage "756" @default.
• W1520363931 startingPage "751" @default.
• W1520363931 abstract "DNA hyperdiploidy is a favorable prognostic factor in childhood acute lymphoblastic leukemia (ALL). The explanation for this prognostic significance is largely unknown. We have studied whether DNA ploidy was related to cellular resistance to 12 drugs, assessed with the methyl- thiazol-tetrazolium assay, in samples of 74 children with common (CD10+ precursor B-cell) ALL. Sixteen patients had hyperdiploid ALL cells and 58 patients had nonhyperdiploid ALL cells. Hyperdiploid ALL cells were more sensitive to mercaptopurine (median, 9.0-fold; P = .000003), to thioguanine (1.4-fold; P = .023), to cytarabine (1.8-fold; P = .016), and to I-asparaginase (19.5-fold; P = .022) than were nonhyperdiploid ALL cells. In contrast, these two ploidy groups did not differ significantly in resistance to prednisolone, dexamethasone, vincristine, vindesine, daunorubicin, doxorubicin, mitoxantrone, and teniposide. The percentage of S-phase cells was higher (P = .05) in the hyperdiploid ALL samples (median, 8.5%) than in the nonhyperdiploid ALL samples (median, 5.7%). However, the percentage of cells in S-phase was not significantly related to in vitro drug resistance. We conclude that the favorable prognosis associated with DNA hyperdiploidy in childhood common ALL may be explained by a relative sensitivity of hyperdiploid common ALL cells to antimetabolites, especially to mercaptopurine and to I-asparaginase." @default.
• W1520363931 created "2016-06-24" @default.
• W1520363931 creator A5035292815 @default.
• W1520363931 creator A5035606379 @default.
• W1520363931 creator A5038178698 @default.
• W1520363931 creator A5041917486 @default.
• W1520363931 creator A5043037950 @default.
• W1520363931 creator A5055598220 @default.
• W1520363931 date "1995-02-01" @default.
• W1520363931 modified "2023-10-02" @default.
• W1520363931 title "Favorable prognosis of hyperdiploid common acute lymphoblastic leukemia may be explained by sensitivity to antimetabolites and other drugs: results of an in vitro study" @default.
• W1520363931 cites W103523220 @default.
• W1520363931 cites W1502033771 @default.
• W1520363931 cites W1556688334 @default.
• W1520363931 cites W1597766366 @default.
• W1520363931 cites W1755692891 @default.
• W1520363931 cites W1817702060 @default.
• W1520363931 cites W1894115693 @default.
• W1520363931 cites W195883502 @default.
• W1520363931 cites W1972954377 @default.
• W1520363931 cites W1981311372 @default.
• W1520363931 cites W1981571451 @default.
• W1520363931 cites W2001596861 @default.
• W1520363931 cites W2017886169 @default.
• W1520363931 cites W2020980159 @default.
• W1520363931 cites W2030579061 @default.
• W1520363931 cites W2031807032 @default.
• W1520363931 cites W2045615971 @default.
• W1520363931 cites W2052344360 @default.
• W1520363931 cites W2068134182 @default.
• W1520363931 cites W2069318633 @default.
• W1520363931 cites W2079847585 @default.
• W1520363931 cites W2093467508 @default.
• W1520363931 cites W2098399116 @default.
• W1520363931 cites W2128478938 @default.
• W1520363931 cites W2129762592 @default.
• W1520363931 cites W2271752622 @default.
• W1520363931 cites W2278728288 @default.
• W1520363931 cites W2396850808 @default.
• W1520363931 cites W2412438836 @default.
• W1520363931 cites W2413697767 @default.
• W1520363931 cites W287317492 @default.
• W1520363931 cites W307794556 @default.
• W1520363931 cites W8223099 @default.
• W1520363931 doi "https://doi.org/10.1182/blood.v85.3.751.bloodjournal853751" @default.
• W1520363931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7833478" @default.
• W1520363931 hasPublicationYear "1995" @default.
• W1520363931 type Work @default.
• W1520363931 sameAs 1520363931 @default.
• W1520363931 citedByCount "146" @default.
• W1520363931 countsByYear W15203639312012 @default.
• W1520363931 countsByYear W15203639312013 @default.
• W1520363931 countsByYear W15203639312014 @default.
• W1520363931 countsByYear W15203639312015 @default.
• W1520363931 countsByYear W15203639312016 @default.
• W1520363931 countsByYear W15203639312017 @default.
• W1520363931 countsByYear W15203639312020 @default.
• W1520363931 countsByYear W15203639312021 @default.
• W1520363931 countsByYear W15203639312023 @default.
• W1520363931 crossrefType "journal-article" @default.
• W1520363931 hasAuthorship W1520363931A5035292815 @default.
• W1520363931 hasAuthorship W1520363931A5035606379 @default.
• W1520363931 hasAuthorship W1520363931A5038178698 @default.
• W1520363931 hasAuthorship W1520363931A5041917486 @default.
• W1520363931 hasAuthorship W1520363931A5043037950 @default.
• W1520363931 hasAuthorship W1520363931A5055598220 @default.
• W1520363931 hasBestOaLocation W15203639311 @default.
• W1520363931 hasConcept C126322002 @default.
• W1520363931 hasConcept C143998085 @default.
• W1520363931 hasConcept C203014093 @default.
• W1520363931 hasConcept C2776694085 @default.
• W1520363931 hasConcept C2776755627 @default.
• W1520363931 hasConcept C2778041864 @default.
• W1520363931 hasConcept C2778119113 @default.
• W1520363931 hasConcept C2778461978 @default.
• W1520363931 hasConcept C2778707968 @default.
• W1520363931 hasConcept C2778904437 @default.
• W1520363931 hasConcept C2779117419 @default.
• W1520363931 hasConcept C2779429289 @default.
• W1520363931 hasConcept C2779434656 @default.
• W1520363931 hasConcept C2780923524 @default.
• W1520363931 hasConcept C2781021840 @default.
• W1520363931 hasConcept C2781107101 @default.
• W1520363931 hasConcept C2909962599 @default.
• W1520363931 hasConcept C502942594 @default.
• W1520363931 hasConcept C71924100 @default.
• W1520363931 hasConceptScore W1520363931C126322002 @default.
• W1520363931 hasConceptScore W1520363931C143998085 @default.
• W1520363931 hasConceptScore W1520363931C203014093 @default.
• W1520363931 hasConceptScore W1520363931C2776694085 @default.
• W1520363931 hasConceptScore W1520363931C2776755627 @default.
• W1520363931 hasConceptScore W1520363931C2778041864 @default.
• W1520363931 hasConceptScore W1520363931C2778119113 @default.
• W1520363931 hasConceptScore W1520363931C2778461978 @default.
• W1520363931 hasConceptScore W1520363931C2778707968 @default.
• W1520363931 hasConceptScore W1520363931C2778904437 @default.
• W1520363931 hasConceptScore W1520363931C2779117419 @default.
• W1520363931 hasConceptScore W1520363931C2779429289 @default.

• next