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• W1520377062 abstract "We diagnosed a unique case of Merkel cell carcinoma (MCC) coexisting with Bowen's disease on the sole of the foot of a 72‐year‐old man who had worked for about 4 years in a factory handling inorganic arsenic. He had a past history of arsenical keratosis and multiple Bowen's disease. The tumour first appeared as a reddish macule and then showed marked growth over the next month. The tumour was excised and the specimen was examined histopathologically. The tumour consisted of two components: a group of atypical cells representing Bowen's disease in the epidermis and another group of atypical cells with a trabecular pattern characteristic of MCC in the dermis. Neither group of cells showed transitional findings, and the tumour elements were divided by a clear basement membrane. The tumour cells in the dermis were positive for neurone‐specific enolase, and on electron microscopy had dense core granules in the cytoplasm. Inorganic arsenic can cause various cutaneous neoplasms, but to our knowledge, this is the first report of a case of MCC associated with Bowen's disease." @default.
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• W1520377062 date "1998-08-01" @default.
• W1520377062 modified "2023-10-17" @default.
• W1520377062 title "Merkel cell carcinoma, Bowen's disease and chronic occupational arsenic poisoning" @default.
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• W1520377062 doi "https://doi.org/10.1046/j.1365-2133.1998.02369.x" @default.
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