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• W1520378235 abstract "Functionally distinct T-helper (Th) subsets orchestrate immune responses. Maintenance of homeostasis through the tight control of inflammatory Th cells is crucial to avoid autoimmune inflammation. Activation-Induced Cell Death (AICD) regulates homeostasis of T cells, and it has never been investigated in human Th cells. We generated stable clones of inflammatory Th subsets involved in autoimmune diseases, such as Th1, Th17 and Th1/17 cells, from healthy donors (HD) and multiple sclerosis (MS) patients and we measured AICD. We find that human Th1 cells are sensitive, whereas Th17 and Th1/17 are resistant, to AICD. In particular, Th1 cells express high level of FAS-ligand (FASL), which interacts with FAS and leads to caspases' cleavage and ultimately to cell death. In contrast, low FASL expression in Th17 and Th1/17 cells blunts caspase 8 activation and thus reduces cell death. Interestingly, Th cells obtained from healthy individuals and MS patients behave similarly, suggesting that this mechanism could explain the persistence of inflammatory IL-17-producing cells in autoimmune diseases, such as MS, where their generation is particularly substantial." @default.
• W1520378235 created "2016-06-24" @default.
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• W1520378235 date "2015-05-07" @default.
• W1520378235 modified "2023-10-16" @default.
• W1520378235 title "FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients" @default.
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• W1520378235 doi "https://doi.org/10.1038/cddis.2015.100" @default.
• W1520378235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4669842" @default.
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• W1520378235 hasPublicationYear "2015" @default.
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