FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W152039733> ?p ?o ?g. }

• W152039733 endingPage "e46" @default.
• W152039733 startingPage "e46" @default.
• W152039733 abstract "The immune response to an inflammatory stimulus is balanced and orchestrated by stimulatory and inhibitory factors. After a thermal trauma, this balance is disturbed and an excessive immune reaction with increased production and release of proinflammatory cytokines results. The nicotine-stimulated anti-inflammatory reflex offsets this. The goal of this study was to verify that transdermal administration of nicotine downregulates proinflammatory cytokine release after burn trauma.A 30% total body surface area full-thickness rat burn model was used in Sprague Dawley rats (n = 35, male). The experimental animals were divided into a control group, a burn trauma group, a burn trauma group with additional nicotine treatment, and a sham + nicotine group with 5 experimental animals per group. The last 2 groups received a transdermal nicotine administration of 1.75 mg. The concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 were determined in homogenates of hearts, livers, and spleens 12 or 24 hours after burn trauma.Experimental burn trauma resulted in a significant increase in cytokine levels in hearts, livers, and spleens. Nicotine treatment led to a decrease of the effect of the burn trauma with significantly lower concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 compared to the trauma group.This study confirms in a standardized burn model that stimulation of the nicotinic acetylcholine receptor is involved in the regulation of effectory molecules of the immune response. Looking at the results of our study, further experiments designed to explore and evaluate the potency and mechanisms of the immunomodulating effects of this receptor system are warranted." @default.
• W152039733 created "2016-06-24" @default.
• W152039733 creator A5014148235 @default.
• W152039733 creator A5016410863 @default.
• W152039733 creator A5031403380 @default.
• W152039733 creator A5053529402 @default.
• W152039733 creator A5069131330 @default.
• W152039733 creator A5073625454 @default.
• W152039733 creator A5083321893 @default.
• W152039733 creator A5087997812 @default.
• W152039733 date "2014-01-01" @default.
• W152039733 modified "2023-09-23" @default.
• W152039733 title "Inflammatory response to burn trauma: nicotine attenuates proinflammatory cytokine levels." @default.
• W152039733 cites W1965091340 @default.
• W152039733 cites W1981192549 @default.
• W152039733 cites W1989035551 @default.
• W152039733 cites W1991458707 @default.
• W152039733 cites W1995525413 @default.
• W152039733 cites W2002797282 @default.
• W152039733 cites W2003075322 @default.
• W152039733 cites W2010046661 @default.
• W152039733 cites W2022782996 @default.
• W152039733 cites W2044096109 @default.
• W152039733 cites W2051261009 @default.
• W152039733 cites W2056581581 @default.
• W152039733 cites W2063661991 @default.
• W152039733 cites W2069368135 @default.
• W152039733 cites W2073295417 @default.
• W152039733 cites W2074974933 @default.
• W152039733 cites W2085832118 @default.
• W152039733 cites W2093497877 @default.
• W152039733 cites W2104789360 @default.
• W152039733 cites W2119572285 @default.
• W152039733 cites W2129934121 @default.
• W152039733 cites W2161605623 @default.
• W152039733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4276106" @default.
• W152039733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25671045" @default.
• W152039733 hasPublicationYear "2014" @default.
• W152039733 type Work @default.
• W152039733 sameAs 152039733 @default.
• W152039733 citedByCount "5" @default.
• W152039733 countsByYear W1520397332015 @default.
• W152039733 countsByYear W1520397332016 @default.
• W152039733 countsByYear W1520397332017 @default.
• W152039733 crossrefType "journal-article" @default.
• W152039733 hasAuthorship W152039733A5014148235 @default.
• W152039733 hasAuthorship W152039733A5016410863 @default.
• W152039733 hasAuthorship W152039733A5031403380 @default.
• W152039733 hasAuthorship W152039733A5053529402 @default.
• W152039733 hasAuthorship W152039733A5069131330 @default.
• W152039733 hasAuthorship W152039733A5073625454 @default.
• W152039733 hasAuthorship W152039733A5083321893 @default.
• W152039733 hasAuthorship W152039733A5087997812 @default.
• W152039733 hasConcept C126322002 @default.
• W152039733 hasConcept C134018914 @default.
• W152039733 hasConcept C164027704 @default.
• W152039733 hasConcept C17991360 @default.
• W152039733 hasConcept C203014093 @default.
• W152039733 hasConcept C24998067 @default.
• W152039733 hasConcept C2776914184 @default.
• W152039733 hasConcept C2778690821 @default.
• W152039733 hasConcept C2779547902 @default.
• W152039733 hasConcept C42219234 @default.
• W152039733 hasConcept C71924100 @default.
• W152039733 hasConcept C74172505 @default.
• W152039733 hasConcept C8891405 @default.
• W152039733 hasConcept C98274493 @default.
• W152039733 hasConceptScore W152039733C126322002 @default.
• W152039733 hasConceptScore W152039733C134018914 @default.
• W152039733 hasConceptScore W152039733C164027704 @default.
• W152039733 hasConceptScore W152039733C17991360 @default.
• W152039733 hasConceptScore W152039733C203014093 @default.
• W152039733 hasConceptScore W152039733C24998067 @default.
• W152039733 hasConceptScore W152039733C2776914184 @default.
• W152039733 hasConceptScore W152039733C2778690821 @default.
• W152039733 hasConceptScore W152039733C2779547902 @default.
• W152039733 hasConceptScore W152039733C42219234 @default.
• W152039733 hasConceptScore W152039733C71924100 @default.
• W152039733 hasConceptScore W152039733C74172505 @default.
• W152039733 hasConceptScore W152039733C8891405 @default.
• W152039733 hasConceptScore W152039733C98274493 @default.
• W152039733 hasLocation W1520397331 @default.
• W152039733 hasOpenAccess W152039733 @default.
• W152039733 hasPrimaryLocation W1520397331 @default.
• W152039733 hasRelatedWork W1968950346 @default.
• W152039733 hasRelatedWork W1986483524 @default.
• W152039733 hasRelatedWork W1995226963 @default.
• W152039733 hasRelatedWork W2000051396 @default.
• W152039733 hasRelatedWork W2042821764 @default.
• W152039733 hasRelatedWork W2073954945 @default.
• W152039733 hasRelatedWork W2078271276 @default.
• W152039733 hasRelatedWork W2095477109 @default.
• W152039733 hasRelatedWork W2339470923 @default.
• W152039733 hasRelatedWork W3187668649 @default.
• W152039733 hasVolume "14" @default.
• W152039733 isParatext "false" @default.
• W152039733 isRetracted "false" @default.
• W152039733 magId "152039733" @default.

• next