FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520403454> ?p ?o ?g. }

• W1520403454 endingPage "85" @default.
• W1520403454 startingPage "75" @default.
• W1520403454 abstract "Purpose: The purposes of this study are to examine the cytogenetic alterations of pancreatic cancer, by using fluorescent in situ hybridization (FISH), to determine thier correlation with the clinico-pathologic prognostic factors and to identify the cytogenetic factors that can predict the prognosis of pancreatic cancer. Methods: Fresh frozen tissues of pancreatic cancer and normal pancreas that were obtained via pancreatic resection from 20 patients with pancreatic ductal adenocacinoma were analyzed by performing FISH with using locus-specific c-myc, p16, p53 probes and chromosome 18q, 20q probes. We cpmpared the FISH results with the clinico-pathologic prognostic factors. We also examined 16 paraffin-embedded tissues of pancreatic cancer by performing immunohistochemical staining (IHC) with monoclonal antibody to c-myc, p16, p53 and DPC. We then evaluated the correlation between the results of FISH and the results of IHC. Results: At least one alteration of genes or chromosomes was detected in 18 (90.0%) of the 20 pancreatic cancer tissues by FISH, as compared with no alternation in the normal pancreatic tissues: these alteration were an increased copy number of c-myc (66.7%), a decreased copy number of p16 (70.6%), deletion of p53 (100%), loss of chromosome 18q (56.3%) and gain of chromosome 20q (45.0%). IHC demonstrated overexpression of c-myc and p53 in 31.3% and 50.0% of the pancreatic cancer specimens, respectively, and the loss of expressions of p16 and DPC in 25.0% and 93.3% of the pancreatic cancer specimens, respectively. The concordance rate of IHC with FISH was 33.3% to 61.5%. Analysis of the correlation between the cytogenetic changes identified by FISH or IHC and the pathologic prognostic factors showed that only chromosome 20q gain was significantly correlated with the histologic grade (p=0.098) and lymphovascular invasion (p=0.092). However there was no clinical correlation of the cytogenetic changes with respect to recurrence after operation. Conclusion: This study confirms that most pancreatic cancers have cytogenetic alternations, as can be determined by FISH. Especially, the correlation between chromosome 20q gain and the prognostic pathologic factors offers the possibility of a new prognostic biologic marker located in chromosome 20q. However, further studies with more cases are needed to clarify the clinical significance of cytogenetic alternations in pancreatic cancer." @default.
• W1520403454 created "2016-06-24" @default.
• W1520403454 creator A5008904691 @default.
• W1520403454 creator A5029879886 @default.
• W1520403454 creator A5036612533 @default.
• W1520403454 creator A5051327843 @default.
• W1520403454 creator A5051695985 @default.
• W1520403454 creator A5067393591 @default.
• W1520403454 creator A5088951998 @default.
• W1520403454 creator A5090497649 @default.
• W1520403454 date "2008-03-01" @default.
• W1520403454 modified "2023-09-24" @default.
• W1520403454 title "형광 동소 보합법을 이용한 췌장암의 세포유전학적 변화에 대한 분석과 그 임상적 의의" @default.
• W1520403454 hasPublicationYear "2008" @default.
• W1520403454 type Work @default.
• W1520403454 sameAs 1520403454 @default.
• W1520403454 citedByCount "0" @default.
• W1520403454 crossrefType "dissertation" @default.
• W1520403454 hasAuthorship W1520403454A5008904691 @default.
• W1520403454 hasAuthorship W1520403454A5029879886 @default.
• W1520403454 hasAuthorship W1520403454A5036612533 @default.
• W1520403454 hasAuthorship W1520403454A5051327843 @default.
• W1520403454 hasAuthorship W1520403454A5051695985 @default.
• W1520403454 hasAuthorship W1520403454A5067393591 @default.
• W1520403454 hasAuthorship W1520403454A5088951998 @default.
• W1520403454 hasAuthorship W1520403454A5090497649 @default.
• W1520403454 hasConcept C104317684 @default.
• W1520403454 hasConcept C121608353 @default.
• W1520403454 hasConcept C134018914 @default.
• W1520403454 hasConcept C142724271 @default.
• W1520403454 hasConcept C160798450 @default.
• W1520403454 hasConcept C167752854 @default.
• W1520403454 hasConcept C204232928 @default.
• W1520403454 hasConcept C2777542201 @default.
• W1520403454 hasConcept C2778764654 @default.
• W1520403454 hasConcept C2780210213 @default.
• W1520403454 hasConcept C30481170 @default.
• W1520403454 hasConcept C502942594 @default.
• W1520403454 hasConcept C54355233 @default.
• W1520403454 hasConcept C71924100 @default.
• W1520403454 hasConcept C74864618 @default.
• W1520403454 hasConcept C86803240 @default.
• W1520403454 hasConceptScore W1520403454C104317684 @default.
• W1520403454 hasConceptScore W1520403454C121608353 @default.
• W1520403454 hasConceptScore W1520403454C134018914 @default.
• W1520403454 hasConceptScore W1520403454C142724271 @default.
• W1520403454 hasConceptScore W1520403454C160798450 @default.
• W1520403454 hasConceptScore W1520403454C167752854 @default.
• W1520403454 hasConceptScore W1520403454C204232928 @default.
• W1520403454 hasConceptScore W1520403454C2777542201 @default.
• W1520403454 hasConceptScore W1520403454C2778764654 @default.
• W1520403454 hasConceptScore W1520403454C2780210213 @default.
• W1520403454 hasConceptScore W1520403454C30481170 @default.
• W1520403454 hasConceptScore W1520403454C502942594 @default.
• W1520403454 hasConceptScore W1520403454C54355233 @default.
• W1520403454 hasConceptScore W1520403454C71924100 @default.
• W1520403454 hasConceptScore W1520403454C74864618 @default.
• W1520403454 hasConceptScore W1520403454C86803240 @default.
• W1520403454 hasIssue "1" @default.
• W1520403454 hasLocation W15204034541 @default.
• W1520403454 hasOpenAccess W1520403454 @default.
• W1520403454 hasPrimaryLocation W15204034541 @default.
• W1520403454 hasVolume "12" @default.
• W1520403454 isParatext "false" @default.
• W1520403454 isRetracted "false" @default.
• W1520403454 magId "1520403454" @default.
• W1520403454 workType "dissertation" @default.