Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520441844> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1520441844 endingPage "4179" @default.
- W1520441844 startingPage "4175" @default.
- W1520441844 abstract "Thyroid hormones may stimulate or repress transcriptional activity depending upon the specific gene. Whereas, a palindromic DNA sequence, TREpal, mediates positive regulation by thyroid hormone, the negative response element (nT3RE) remains undefined. Therefore, we have examined the DNA sequences that mediate the inhibitory effects of thyroid hormone on the transcription of the beta-subunit gene of rat thyrotropin (rTSH beta). In rat pituitary tumor cells (GH3), transient expression of plasmid constructs containing the putative nT3RE of rTSH beta mediated negative regulation by L-triiodothyronine (T3). Since this nT3RE contained sequences which resembled a half-site motif of the consensus T3RE and the idealized palindrome (TREpal), we tested a construct containing this half-site motif in the same cells. T3 decreased the activity of this plasmid. Cotransfection studies in T3-receptor (T3R)-deficient cells indicated that either alpha or beta isoforms of T3R were required for the inhibitory effects of the hormone. Both T3R isomers bind to DNA sequences containing the nT3RE from rTSH beta DNA or the half-site motif of TREpal. In summary, our results show that the repressive properties of T3 are mediated by a nT3RE from rTSH beta. Unexpectedly, this motif resembles a half-site component of TREpal which enhances promoter activity in response to T3." @default.
- W1520441844 created "2016-06-24" @default.
- W1520441844 creator A5037959449 @default.
- W1520441844 creator A5087721092 @default.
- W1520441844 date "1994-02-01" @default.
- W1520441844 modified "2023-10-15" @default.
- W1520441844 title "Characteristics of a negative thyroid hormone response element." @default.
- W1520441844 cites W1487719143 @default.
- W1520441844 cites W1517784889 @default.
- W1520441844 cites W1547233041 @default.
- W1520441844 cites W1556768294 @default.
- W1520441844 cites W1556887581 @default.
- W1520441844 cites W1588998681 @default.
- W1520441844 cites W1598062712 @default.
- W1520441844 cites W1967161001 @default.
- W1520441844 cites W1975825741 @default.
- W1520441844 cites W1987040411 @default.
- W1520441844 cites W1990437398 @default.
- W1520441844 cites W1990996028 @default.
- W1520441844 cites W1992289621 @default.
- W1520441844 cites W1993243592 @default.
- W1520441844 cites W2000902147 @default.
- W1520441844 cites W2002235717 @default.
- W1520441844 cites W2011467252 @default.
- W1520441844 cites W2015847180 @default.
- W1520441844 cites W2018442116 @default.
- W1520441844 cites W2055053601 @default.
- W1520441844 cites W2058232931 @default.
- W1520441844 cites W2075232957 @default.
- W1520441844 cites W2112823160 @default.
- W1520441844 cites W2119671728 @default.
- W1520441844 cites W2120176836 @default.
- W1520441844 cites W2148946263 @default.
- W1520441844 cites W388190409 @default.
- W1520441844 doi "https://doi.org/10.1016/s0021-9258(17)41759-5" @default.
- W1520441844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8307979" @default.
- W1520441844 hasPublicationYear "1994" @default.
- W1520441844 type Work @default.
- W1520441844 sameAs 1520441844 @default.
- W1520441844 citedByCount "62" @default.
- W1520441844 countsByYear W15204418442012 @default.
- W1520441844 countsByYear W15204418442013 @default.
- W1520441844 countsByYear W15204418442014 @default.
- W1520441844 countsByYear W15204418442015 @default.
- W1520441844 countsByYear W15204418442016 @default.
- W1520441844 countsByYear W15204418442018 @default.
- W1520441844 countsByYear W15204418442019 @default.
- W1520441844 crossrefType "journal-article" @default.
- W1520441844 hasAuthorship W1520441844A5037959449 @default.
- W1520441844 hasAuthorship W1520441844A5087721092 @default.
- W1520441844 hasBestOaLocation W15204418441 @default.
- W1520441844 hasConcept C126322002 @default.
- W1520441844 hasConcept C134018914 @default.
- W1520441844 hasConcept C17744445 @default.
- W1520441844 hasConcept C199539241 @default.
- W1520441844 hasConcept C200288055 @default.
- W1520441844 hasConcept C526584372 @default.
- W1520441844 hasConcept C71315377 @default.
- W1520441844 hasConcept C71924100 @default.
- W1520441844 hasConcept C86803240 @default.
- W1520441844 hasConceptScore W1520441844C126322002 @default.
- W1520441844 hasConceptScore W1520441844C134018914 @default.
- W1520441844 hasConceptScore W1520441844C17744445 @default.
- W1520441844 hasConceptScore W1520441844C199539241 @default.
- W1520441844 hasConceptScore W1520441844C200288055 @default.
- W1520441844 hasConceptScore W1520441844C526584372 @default.
- W1520441844 hasConceptScore W1520441844C71315377 @default.
- W1520441844 hasConceptScore W1520441844C71924100 @default.
- W1520441844 hasConceptScore W1520441844C86803240 @default.
- W1520441844 hasIssue "6" @default.
- W1520441844 hasLocation W15204418441 @default.
- W1520441844 hasOpenAccess W1520441844 @default.
- W1520441844 hasPrimaryLocation W15204418441 @default.
- W1520441844 hasRelatedWork W1966504330 @default.
- W1520441844 hasRelatedWork W1966775726 @default.
- W1520441844 hasRelatedWork W1979139803 @default.
- W1520441844 hasRelatedWork W1991560548 @default.
- W1520441844 hasRelatedWork W2030889776 @default.
- W1520441844 hasRelatedWork W2037631372 @default.
- W1520441844 hasRelatedWork W2040058909 @default.
- W1520441844 hasRelatedWork W2132898409 @default.
- W1520441844 hasRelatedWork W2748952813 @default.
- W1520441844 hasRelatedWork W4249176446 @default.
- W1520441844 hasVolume "269" @default.
- W1520441844 isParatext "false" @default.
- W1520441844 isRetracted "false" @default.
- W1520441844 magId "1520441844" @default.
- W1520441844 workType "article" @default.