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• W1520463505 abstract "Vpx encoded by HIV-2 and SIVsm enhances retroviral reverse transcription in macrophages in vitro by mediating the degradation of the host SAMHD1 protein that hydrolyzes dNTPs and by elevating cellular dNTP levels. Here we employed RT-SHIV constructs (SIV encoding HIV-1 RT) to investigate the contribution of Vpx to the potency of NRTIs, which compete against dNTPs, in monocyte-derived macrophages (MDMs) and activated CD4(+) T cells. Relative to HIV-1, both SIV and RT-SHIV exhibited reduced sensitivities to AZT, 3TC and TDF in MDMs but not in activated CD4(+) T cells. However, when SIV and RT-SHIV constructs not coding for Vpx were utilized, we observed greater sensitivities to all NRTIs tested using activated CD4(+) T cells relative to the Vpx-coding counterparts. This latter phenomenon was observed for AZT only when using MDMs. Our data suggest that Vpx in RT-SHIVs may underestimate the antiviral efficacy of NRTIs in a cell type dependent manner." @default.
• W1520463505 created "2016-06-24" @default.
• W1520463505 creator A5035101090 @default.
• W1520463505 creator A5054825542 @default.
• W1520463505 creator A5085865289 @default.
• W1520463505 creator A5087052821 @default.
• W1520463505 date "2015-11-01" @default.
• W1520463505 modified "2023-10-15" @default.
• W1520463505 title "Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4+ T cells" @default.
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• W1520463505 cites W1983711023 @default.
• W1520463505 cites W1989189545 @default.
• W1520463505 cites W1989633434 @default.
• W1520463505 cites W1992007798 @default.
• W1520463505 cites W1996295511 @default.
• W1520463505 cites W2000195190 @default.
• W1520463505 cites W2003789674 @default.
• W1520463505 cites W2004013930 @default.
• W1520463505 cites W2005910303 @default.
• W1520463505 cites W2011528143 @default.
• W1520463505 cites W2014616178 @default.
• W1520463505 cites W2017044687 @default.
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• W1520463505 cites W2027853473 @default.
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• W1520463505 doi "https://doi.org/10.1016/j.virol.2015.08.006" @default.
• W1520463505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4619155" @default.
• W1520463505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26319213" @default.
• W1520463505 hasPublicationYear "2015" @default.
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