FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520488118> ?p ?o ?g. }

• W1520488118 endingPage "453" @default.
• W1520488118 startingPage "447" @default.
• W1520488118 abstract "The effects of opsonised zymosan and of acetylated low-density lipoprotein (AcLDL) on the synthesis and secretion of apolipoprotein E (apoE), and of apoE mRNA abundance, have been studied in human-monocyte-derived macrophages (MDM). Stimulation by opsonised zymosan led to a concentration-dependent increase in apoE secretion; non-opsonised zymosan was without effect. Incubation with AcLDL led to a concentration-dependent elevation in apoE synthesis which paralleled the increase in cellular cholesterol content. The opsonised-zymosan-induced stimulation of apoE production was additive to that resulting from cholesterol loading with AcLDL. Opsonised zymosan alone did not affect the cholesterol content of MDM. Cholesterol-loaded MDM remained responsive to opsonised zymosan stimulation, displaying a 3.5-fold elevation in apoE secretion as compared to their non-stimulated counterparts. Cell-associated apoE remained at trace levels under all conditions of cell treatment. Studies involving [35S]methionine incorporation showed de novo synthesis of apoE to be enhanced in both cholesterol-loaded and opsonised-zymosan-stimulated macrophages. Estimation of apoE mRNA in opsonised-zymosan-stimulated and control MDM by dot-blot analysis revealed similar message abundance; by contrast, elevation in cellular cholesterol content following incubation with modified LDL led to a significant increase in apoE mRNA levels. We conclude that the opsonised-zymosan-induced stimulation of apoE synthesis and secretion in human MDM may occur by a mechanism(s) independent of cellular cholesterol content." @default.
• W1520488118 created "2016-06-24" @default.
• W1520488118 creator A5011127352 @default.
• W1520488118 creator A5058946936 @default.
• W1520488118 creator A5061389868 @default.
• W1520488118 creator A5082331899 @default.
• W1520488118 creator A5085957154 @default.
• W1520488118 date "1990-04-01" @default.
• W1520488118 modified "2023-09-29" @default.
• W1520488118 title "Apolipoprotein E expression by human-monocyte-derived macrophages. Modulation by opsonised zymosan and cholesterol" @default.
• W1520488118 cites W1026754737 @default.
• W1520488118 cites W1492043593 @default.
• W1520488118 cites W1508691110 @default.
• W1520488118 cites W1549363335 @default.
• W1520488118 cites W1574027562 @default.
• W1520488118 cites W1620258338 @default.
• W1520488118 cites W1678778738 @default.
• W1520488118 cites W170055736 @default.
• W1520488118 cites W1736154854 @default.
• W1520488118 cites W1775749144 @default.
• W1520488118 cites W1779067738 @default.
• W1520488118 cites W1920171370 @default.
• W1520488118 cites W1926274025 @default.
• W1520488118 cites W1940775645 @default.
• W1520488118 cites W1965895437 @default.
• W1520488118 cites W1967922054 @default.
• W1520488118 cites W1972960247 @default.
• W1520488118 cites W1975908451 @default.
• W1520488118 cites W1995032745 @default.
• W1520488118 cites W2003577247 @default.
• W1520488118 cites W2012788717 @default.
• W1520488118 cites W2017640755 @default.
• W1520488118 cites W2024352183 @default.
• W1520488118 cites W2034968148 @default.
• W1520488118 cites W2042819132 @default.
• W1520488118 cites W2049401036 @default.
• W1520488118 cites W2050562947 @default.
• W1520488118 cites W2064179373 @default.
• W1520488118 cites W2067963408 @default.
• W1520488118 cites W2069435067 @default.
• W1520488118 cites W2072422194 @default.
• W1520488118 cites W2092602709 @default.
• W1520488118 cites W2120626817 @default.
• W1520488118 cites W2120651556 @default.
• W1520488118 cites W2146989945 @default.
• W1520488118 cites W2147413218 @default.
• W1520488118 cites W2147812369 @default.
• W1520488118 cites W2153218744 @default.
• W1520488118 cites W2153716751 @default.
• W1520488118 cites W2155045365 @default.
• W1520488118 cites W2162458714 @default.
• W1520488118 cites W2163251343 @default.
• W1520488118 cites W2165482355 @default.
• W1520488118 cites W2170564808 @default.
• W1520488118 cites W2183504660 @default.
• W1520488118 cites W2184563284 @default.
• W1520488118 cites W2398870494 @default.
• W1520488118 cites W2417654140 @default.
• W1520488118 cites W4239088562 @default.
• W1520488118 doi "https://doi.org/10.1111/j.1432-1033.1990.tb15509.x" @default.
• W1520488118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2338086" @default.
• W1520488118 hasPublicationYear "1990" @default.
• W1520488118 type Work @default.
• W1520488118 sameAs 1520488118 @default.
• W1520488118 citedByCount "23" @default.
• W1520488118 countsByYear W15204881182013 @default.
• W1520488118 countsByYear W15204881182016 @default.
• W1520488118 crossrefType "journal-article" @default.
• W1520488118 hasAuthorship W1520488118A5011127352 @default.
• W1520488118 hasAuthorship W1520488118A5058946936 @default.
• W1520488118 hasAuthorship W1520488118A5061389868 @default.
• W1520488118 hasAuthorship W1520488118A5082331899 @default.
• W1520488118 hasAuthorship W1520488118A5085957154 @default.
• W1520488118 hasBestOaLocation W15204881181 @default.
• W1520488118 hasConcept C126322002 @default.
• W1520488118 hasConcept C134018914 @default.
• W1520488118 hasConcept C185592680 @default.
• W1520488118 hasConcept C202751555 @default.
• W1520488118 hasConcept C203014093 @default.
• W1520488118 hasConcept C24998067 @default.
• W1520488118 hasConcept C2778163477 @default.
• W1520488118 hasConcept C2778870864 @default.
• W1520488118 hasConcept C2779134260 @default.
• W1520488118 hasConcept C2781184567 @default.
• W1520488118 hasConcept C49039625 @default.
• W1520488118 hasConcept C55493867 @default.
• W1520488118 hasConcept C57089818 @default.
• W1520488118 hasConcept C62746215 @default.
• W1520488118 hasConcept C71924100 @default.
• W1520488118 hasConcept C86803240 @default.
• W1520488118 hasConceptScore W1520488118C126322002 @default.
• W1520488118 hasConceptScore W1520488118C134018914 @default.
• W1520488118 hasConceptScore W1520488118C185592680 @default.
• W1520488118 hasConceptScore W1520488118C202751555 @default.
• W1520488118 hasConceptScore W1520488118C203014093 @default.
• W1520488118 hasConceptScore W1520488118C24998067 @default.
• W1520488118 hasConceptScore W1520488118C2778163477 @default.
• W1520488118 hasConceptScore W1520488118C2778870864 @default.

• next