Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520493856> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1520493856 endingPage "133" @default.
- W1520493856 startingPage "125" @default.
- W1520493856 abstract "The main difficulty in providing effective treatment of patients with cancer is distinguishing between tumor and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities (such as the BCR-ABL fusion protein) represent ideal therapeutic targets since they are unique to the disease state. A major challenge, however, is how to deliver the specific anti-tumor agent into every tumor cell. In this report we describe the use of a novel strategy to introduce specific anti-tumor reagents into every tumor cell. It uses retroviral vectors encoding both antisense transcripts specific for the BCR-ABLp190 fusion junction (the specific anti-tumor drug) and a truncated human CD5 cDNA, which allows selection of the infected cells. In order to coexpress the anti-sense molecule with the truncated human CD5 gene, the picornavirus internal ribosome-entry site was incorporated in the constructs. When the antisense transcripts in the CD5-retroviral vector were introduced into Ba/F3+p190 cells rendered interleukin 3 (IL-3) independent by expression of the BCR-ABL sequences, the cells died upon IL-3 withdrawal, as measured by the absence of CD5-positive cells. Control Ba/F3+p210 cells infected with the same virus did not die in the absence of IL-3. These data suggest a novel strategy for cancer treatment which incorporates the use of a retrovirus coexpressing both a selectable surface marker and a tumor-specific agent." @default.
- W1520493856 created "2016-06-24" @default.
- W1520493856 creator A5013855315 @default.
- W1520493856 creator A5075974674 @default.
- W1520493856 date "1996-01-01" @default.
- W1520493856 modified "2023-10-18" @default.
- W1520493856 title "Retroviral Vector Design for Gene Therapy of Cancer: Specific Inhibition and Tagging of BCR-ABLp190 Cells" @default.
- W1520493856 cites W1754111038 @default.
- W1520493856 cites W1765454988 @default.
- W1520493856 cites W186063976 @default.
- W1520493856 cites W1972724663 @default.
- W1520493856 cites W1972804480 @default.
- W1520493856 cites W1991148746 @default.
- W1520493856 cites W1992063032 @default.
- W1520493856 cites W1994954403 @default.
- W1520493856 cites W1998919839 @default.
- W1520493856 cites W2005654549 @default.
- W1520493856 cites W2006239014 @default.
- W1520493856 cites W2006518962 @default.
- W1520493856 cites W2019616754 @default.
- W1520493856 cites W2020954035 @default.
- W1520493856 cites W2033753214 @default.
- W1520493856 cites W2038588592 @default.
- W1520493856 cites W2040323778 @default.
- W1520493856 cites W2040396943 @default.
- W1520493856 cites W2041440798 @default.
- W1520493856 cites W2087031840 @default.
- W1520493856 cites W2089483984 @default.
- W1520493856 cites W2115524556 @default.
- W1520493856 cites W2142550741 @default.
- W1520493856 cites W2400794246 @default.
- W1520493856 cites W2414770053 @default.
- W1520493856 cites W4251900046 @default.
- W1520493856 doi "https://doi.org/10.1007/bf03402208" @default.
- W1520493856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230033" @default.
- W1520493856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8900540" @default.
- W1520493856 hasPublicationYear "1996" @default.
- W1520493856 type Work @default.
- W1520493856 sameAs 1520493856 @default.
- W1520493856 citedByCount "12" @default.
- W1520493856 countsByYear W15204938562015 @default.
- W1520493856 crossrefType "journal-article" @default.
- W1520493856 hasAuthorship W1520493856A5013855315 @default.
- W1520493856 hasAuthorship W1520493856A5075974674 @default.
- W1520493856 hasBestOaLocation W15204938561 @default.
- W1520493856 hasConcept C104317684 @default.
- W1520493856 hasConcept C111599444 @default.
- W1520493856 hasConcept C111829193 @default.
- W1520493856 hasConcept C121608353 @default.
- W1520493856 hasConcept C123894998 @default.
- W1520493856 hasConcept C159047783 @default.
- W1520493856 hasConcept C2522874641 @default.
- W1520493856 hasConcept C2778431562 @default.
- W1520493856 hasConcept C32470452 @default.
- W1520493856 hasConcept C40767141 @default.
- W1520493856 hasConcept C502942594 @default.
- W1520493856 hasConcept C54355233 @default.
- W1520493856 hasConcept C86803240 @default.
- W1520493856 hasConcept C96232424 @default.
- W1520493856 hasConceptScore W1520493856C104317684 @default.
- W1520493856 hasConceptScore W1520493856C111599444 @default.
- W1520493856 hasConceptScore W1520493856C111829193 @default.
- W1520493856 hasConceptScore W1520493856C121608353 @default.
- W1520493856 hasConceptScore W1520493856C123894998 @default.
- W1520493856 hasConceptScore W1520493856C159047783 @default.
- W1520493856 hasConceptScore W1520493856C2522874641 @default.
- W1520493856 hasConceptScore W1520493856C2778431562 @default.
- W1520493856 hasConceptScore W1520493856C32470452 @default.
- W1520493856 hasConceptScore W1520493856C40767141 @default.
- W1520493856 hasConceptScore W1520493856C502942594 @default.
- W1520493856 hasConceptScore W1520493856C54355233 @default.
- W1520493856 hasConceptScore W1520493856C86803240 @default.
- W1520493856 hasConceptScore W1520493856C96232424 @default.
- W1520493856 hasIssue "1" @default.
- W1520493856 hasLocation W15204938561 @default.
- W1520493856 hasLocation W15204938562 @default.
- W1520493856 hasLocation W15204938563 @default.
- W1520493856 hasLocation W15204938564 @default.
- W1520493856 hasLocation W15204938565 @default.
- W1520493856 hasOpenAccess W1520493856 @default.
- W1520493856 hasPrimaryLocation W15204938561 @default.
- W1520493856 hasRelatedWork W1979273582 @default.
- W1520493856 hasRelatedWork W2059257518 @default.
- W1520493856 hasRelatedWork W2368115647 @default.
- W1520493856 hasRelatedWork W2373152171 @default.
- W1520493856 hasRelatedWork W2376342659 @default.
- W1520493856 hasRelatedWork W2385701741 @default.
- W1520493856 hasRelatedWork W2390912645 @default.
- W1520493856 hasRelatedWork W2561261622 @default.
- W1520493856 hasRelatedWork W2801134602 @default.
- W1520493856 hasRelatedWork W4253457663 @default.
- W1520493856 hasVolume "2" @default.
- W1520493856 isParatext "false" @default.
- W1520493856 isRetracted "false" @default.
- W1520493856 magId "1520493856" @default.
- W1520493856 workType "article" @default.