Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520503961> ?p ?o ?g. }
- W1520503961 endingPage "1480" @default.
- W1520503961 startingPage "1470" @default.
- W1520503961 abstract "In the present study, we investigated the role of glutathione (GSH) and its related enzymes in Sprague Dawley (SD) rats subjected to microcystin-leucine-arginine (MCLR)-induced hepatotoxicity. SD rats were intraperitoneally (i.p.) injected with MCLR after pretreating with or without buthionine-(S,R)-sulfoximine (BSO), an inhibitor of GSH synthesis. The depletion of GSH with BSO enhanced MCLR-induced oxidative stress, resulting in more severe liver damage and higher MCLR accumulation. Similarly, the contents of malondialdehyde (MDA), total GSH (T-GSH), oxidized GSH (GSSG) and GSH were significantly enhanced in BSO pretreated rats following MCLR treatment. The study showed that the transcription of GSH-related enzymes such as glutathione-S-transferase (GST), γ-glutamylcysteine synthetase (γ-GCS), glutathione reductase (GR) varied in different ways (expect for glutathione peroxidase (GPx), whose gene expression was induced in all treated groups) with or without BSO pretreatment before MCLR exposure, suggesting an adaptative response of GSH-related enzymes at transcription level to combat enhancement of oxidative stress induced by MCLR when pretreated with BSO. These data suggested the tissues with low GSH concentration are highly vulnerable to MCLR toxicity and GSH was critical for the detoxification in MCLR-induced hepatotoxicity in vivo." @default.
- W1520503961 created "2016-06-24" @default.
- W1520503961 creator A5010481244 @default.
- W1520503961 creator A5011487190 @default.
- W1520503961 creator A5016786612 @default.
- W1520503961 creator A5049857586 @default.
- W1520503961 creator A5058569822 @default.
- W1520503961 creator A5073939600 @default.
- W1520503961 creator A5082857859 @default.
- W1520503961 creator A5089638046 @default.
- W1520503961 date "2014-06-25" @default.
- W1520503961 modified "2023-09-24" @default.
- W1520503961 title "The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats" @default.
- W1520503961 cites W1535828429 @default.
- W1520503961 cites W1545899030 @default.
- W1520503961 cites W1581414347 @default.
- W1520503961 cites W1965718556 @default.
- W1520503961 cites W1968964136 @default.
- W1520503961 cites W1971833474 @default.
- W1520503961 cites W1976353558 @default.
- W1520503961 cites W1983310681 @default.
- W1520503961 cites W1993904495 @default.
- W1520503961 cites W1995788838 @default.
- W1520503961 cites W2000810227 @default.
- W1520503961 cites W2004256319 @default.
- W1520503961 cites W2005377538 @default.
- W1520503961 cites W2008878988 @default.
- W1520503961 cites W2010311619 @default.
- W1520503961 cites W2010934795 @default.
- W1520503961 cites W2013752282 @default.
- W1520503961 cites W2014043171 @default.
- W1520503961 cites W2021236594 @default.
- W1520503961 cites W2023988904 @default.
- W1520503961 cites W2041529020 @default.
- W1520503961 cites W2042903489 @default.
- W1520503961 cites W2044808644 @default.
- W1520503961 cites W2045509536 @default.
- W1520503961 cites W2045526900 @default.
- W1520503961 cites W2049733012 @default.
- W1520503961 cites W2050054653 @default.
- W1520503961 cites W2051786885 @default.
- W1520503961 cites W2056074767 @default.
- W1520503961 cites W2058169080 @default.
- W1520503961 cites W2065856887 @default.
- W1520503961 cites W2069842461 @default.
- W1520503961 cites W2074525235 @default.
- W1520503961 cites W2092235810 @default.
- W1520503961 cites W2093038992 @default.
- W1520503961 cites W2095080787 @default.
- W1520503961 cites W2100192252 @default.
- W1520503961 cites W2103965206 @default.
- W1520503961 cites W2112683748 @default.
- W1520503961 cites W2112965326 @default.
- W1520503961 cites W2118519973 @default.
- W1520503961 cites W2123705115 @default.
- W1520503961 cites W2143762207 @default.
- W1520503961 cites W2148975292 @default.
- W1520503961 cites W2156801294 @default.
- W1520503961 cites W2159173692 @default.
- W1520503961 cites W2161269223 @default.
- W1520503961 cites W2166337262 @default.
- W1520503961 cites W2169457842 @default.
- W1520503961 cites W3148583569 @default.
- W1520503961 cites W4245957869 @default.
- W1520503961 cites W4293247451 @default.
- W1520503961 cites W4376595564 @default.
- W1520503961 cites W944568383 @default.
- W1520503961 doi "https://doi.org/10.1002/tox.22017" @default.
- W1520503961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24964298" @default.
- W1520503961 hasPublicationYear "2014" @default.
- W1520503961 type Work @default.
- W1520503961 sameAs 1520503961 @default.
- W1520503961 citedByCount "26" @default.
- W1520503961 countsByYear W15205039612014 @default.
- W1520503961 countsByYear W15205039612015 @default.
- W1520503961 countsByYear W15205039612016 @default.
- W1520503961 countsByYear W15205039612017 @default.
- W1520503961 countsByYear W15205039612018 @default.
- W1520503961 countsByYear W15205039612019 @default.
- W1520503961 countsByYear W15205039612020 @default.
- W1520503961 countsByYear W15205039612021 @default.
- W1520503961 countsByYear W15205039612022 @default.
- W1520503961 countsByYear W15205039612023 @default.
- W1520503961 crossrefType "journal-article" @default.
- W1520503961 hasAuthorship W1520503961A5010481244 @default.
- W1520503961 hasAuthorship W1520503961A5011487190 @default.
- W1520503961 hasAuthorship W1520503961A5016786612 @default.
- W1520503961 hasAuthorship W1520503961A5049857586 @default.
- W1520503961 hasAuthorship W1520503961A5058569822 @default.
- W1520503961 hasAuthorship W1520503961A5073939600 @default.
- W1520503961 hasAuthorship W1520503961A5082857859 @default.
- W1520503961 hasAuthorship W1520503961A5089638046 @default.
- W1520503961 hasConcept C165069038 @default.
- W1520503961 hasConcept C178790620 @default.
- W1520503961 hasConcept C181199279 @default.
- W1520503961 hasConcept C185592680 @default.
- W1520503961 hasConcept C2776151105 @default.
- W1520503961 hasConcept C2777476445 @default.