FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520507377> ?p ?o ?g. }

• W1520507377 endingPage "1887" @default.
• W1520507377 startingPage "1881" @default.
• W1520507377 abstract "Acyloxyacyl hydrolase is a leukocyte enzyme that selectively removes the secondary acyl chains from the lipid A moiety of gram-negative bacterial lipopolysaccharides (LPS). As predicted by the reported contribution of secondary acyl chains to the bioactivities of lipid A analogs, enzymatic deacylation of Salmonella typhimurium Rc LPS substantially reduces its potency in the dermal Shwartzman reaction and in several in vitro assays that measure responses of human endothelial cells and neutrophils, whereas the potency of this LPS for inducing murine splenocyte mitogenesis is affected much less. In the experiments described here, we studied the impact of acyloxyacyl hydrolysis on the bioactivities of several LPS that differ from Salmonella LPS in carbohydrate and lipid A structures. Deacylated LPS from Escherichia coli, Haemophilus influenzae, Neisseria meningitidis, and S. typhimurium were similarly reduced in potency in the Limulus lysate test (30- to 60-fold reduction in potency relative to the corresponding mock-treated LPS), and the ability of all of these deacylated LPS to stimulate neutrophil adherence to human endothelial cells was reduced by a factor of 100 or more. For LPS from E. coli, H. influenzae, and Pseudomonas aeruginosa, the impact of deacylation on spleen cell mitogenesis was also similar to that observed for S. typhimurium LPS: deacylation reduced potency by less than 15-fold. Unexpectedly, the potency of Neisseria LPS in the murine splenocyte mitogenicity test was reduced over 100-fold by deacylation, and deacylated Neisseria LPS could block the mitogenic activity of Neisseria and Salmonella LPS. These studies indicate that the contribution of secondary acyl chains to the bioactivities of a given LPS cannot be predicted with confidence from the reported structure-activity relationships of lipid A or from the behavior of other deacylated LPS." @default.
• W1520507377 created "2016-06-24" @default.
• W1520507377 creator A5065030286 @default.
• W1520507377 creator A5077066310 @default.
• W1520507377 creator A5080303179 @default.
• W1520507377 date "1991-06-01" @default.
• W1520507377 modified "2023-10-18" @default.
• W1520507377 title "Enzymatically deacylated Neisseria lipopolysaccharide (LPS) inhibits murine splenocyte mitogenesis induced by LPS" @default.
• W1520507377 cites W1543949372 @default.
• W1520507377 cites W1555196547 @default.
• W1520507377 cites W155521478 @default.
• W1520507377 cites W1570560342 @default.
• W1520507377 cites W1596878061 @default.
• W1520507377 cites W165921929 @default.
• W1520507377 cites W1767090927 @default.
• W1520507377 cites W1772988620 @default.
• W1520507377 cites W1788271644 @default.
• W1520507377 cites W1829424989 @default.
• W1520507377 cites W1837844789 @default.
• W1520507377 cites W1857899874 @default.
• W1520507377 cites W1910347083 @default.
• W1520507377 cites W1915794092 @default.
• W1520507377 cites W1950398778 @default.
• W1520507377 cites W1957214151 @default.
• W1520507377 cites W1967501462 @default.
• W1520507377 cites W1968834907 @default.
• W1520507377 cites W2002663310 @default.
• W1520507377 cites W2016268785 @default.
• W1520507377 cites W2026217419 @default.
• W1520507377 cites W2033322066 @default.
• W1520507377 cites W2049412080 @default.
• W1520507377 cites W2066834458 @default.
• W1520507377 cites W2069869064 @default.
• W1520507377 cites W2072604399 @default.
• W1520507377 cites W2088738123 @default.
• W1520507377 cites W2090685643 @default.
• W1520507377 cites W2111724437 @default.
• W1520507377 cites W2116047418 @default.
• W1520507377 cites W2123987391 @default.
• W1520507377 cites W2124755314 @default.
• W1520507377 cites W2146749940 @default.
• W1520507377 cites W2149713514 @default.
• W1520507377 cites W2313849458 @default.
• W1520507377 cites W2388756018 @default.
• W1520507377 doi "https://doi.org/10.1128/iai.59.6.1881-1887.1991" @default.
• W1520507377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/257937" @default.
• W1520507377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1903767" @default.
• W1520507377 hasPublicationYear "1991" @default.
• W1520507377 type Work @default.
• W1520507377 sameAs 1520507377 @default.
• W1520507377 citedByCount "34" @default.
• W1520507377 countsByYear W15205073772013 @default.
• W1520507377 countsByYear W15205073772015 @default.
• W1520507377 countsByYear W15205073772016 @default.
• W1520507377 countsByYear W15205073772017 @default.
• W1520507377 countsByYear W15205073772020 @default.
• W1520507377 crossrefType "journal-article" @default.
• W1520507377 hasAuthorship W1520507377A5065030286 @default.
• W1520507377 hasAuthorship W1520507377A5077066310 @default.
• W1520507377 hasAuthorship W1520507377A5080303179 @default.
• W1520507377 hasBestOaLocation W15205073771 @default.
• W1520507377 hasConcept C144464004 @default.
• W1520507377 hasConcept C189976730 @default.
• W1520507377 hasConcept C202751555 @default.
• W1520507377 hasConcept C203014093 @default.
• W1520507377 hasConcept C2776925733 @default.
• W1520507377 hasConcept C2777382900 @default.
• W1520507377 hasConcept C2777954195 @default.
• W1520507377 hasConcept C2778458888 @default.
• W1520507377 hasConcept C2778754761 @default.
• W1520507377 hasConcept C2781065037 @default.
• W1520507377 hasConcept C501593827 @default.
• W1520507377 hasConcept C523546767 @default.
• W1520507377 hasConcept C54355233 @default.
• W1520507377 hasConcept C55493867 @default.
• W1520507377 hasConcept C57992300 @default.
• W1520507377 hasConcept C86803240 @default.
• W1520507377 hasConcept C89423630 @default.
• W1520507377 hasConceptScore W1520507377C144464004 @default.
• W1520507377 hasConceptScore W1520507377C189976730 @default.
• W1520507377 hasConceptScore W1520507377C202751555 @default.
• W1520507377 hasConceptScore W1520507377C203014093 @default.
• W1520507377 hasConceptScore W1520507377C2776925733 @default.
• W1520507377 hasConceptScore W1520507377C2777382900 @default.
• W1520507377 hasConceptScore W1520507377C2777954195 @default.
• W1520507377 hasConceptScore W1520507377C2778458888 @default.
• W1520507377 hasConceptScore W1520507377C2778754761 @default.
• W1520507377 hasConceptScore W1520507377C2781065037 @default.
• W1520507377 hasConceptScore W1520507377C501593827 @default.
• W1520507377 hasConceptScore W1520507377C523546767 @default.
• W1520507377 hasConceptScore W1520507377C54355233 @default.
• W1520507377 hasConceptScore W1520507377C55493867 @default.
• W1520507377 hasConceptScore W1520507377C57992300 @default.
• W1520507377 hasConceptScore W1520507377C86803240 @default.
• W1520507377 hasConceptScore W1520507377C89423630 @default.
• W1520507377 hasIssue "6" @default.
• W1520507377 hasLocation W15205073771 @default.
• W1520507377 hasLocation W15205073772 @default.

• next