Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520509538> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1520509538 endingPage "6" @default.
- W1520509538 startingPage "31" @default.
- W1520509538 abstract "The aim of this study is to describe a modification of the original method of clearing lymph nodes in specimens from rectal adenocarcinoma and its yield in comparison to a control group whose specimens were studied by a manual technique. There were 32 consecutive patients with locally advanced rectal adenocarcinoma. All patients received preoperative radiation therapy (PRT) at doses of 45 Gy, concomitant with 5-fluorouracil at the doses of 450 mg/m2 IV bolus, days 1-5 and 28-33 of PRT; 4-8 weeks later radical surgery with a curative intent was performed. Twenty two specimens were studied by a manual technique consisting of fixation in 10% formalin. Ten specimens were studied with the modified clearing technique consisting of administration through the inferior mesenteric artery of methylene blue; fixation with 10% formalin plus 0.01% of methylene blue; clearing the fat with a sequence of 95% alcohol-100% acetone-100% xylene. In the 32 specimens, 413 lymph nodes were found. Using the manual technique 104 lymph nodes were found (average 4.7 lymph nodes per specimen); 309 lymph nodes by the modified clearing technique (average 30.9 lymph nodes per specimen), (p < 0.0001). Using the manual technique 23 out of 104 lymph nodes (22%) contained metastases. All metastatic lymph nodes measured > 5 mm; 18 out of 23 metastatic lymph nodes were located on the perirectal area (level 2); and five were located in the root of the inferior mesenteric artery (level 5). Using the modified clearing technique 278 out of 309 (89%) lymph nodes measured < 5 mm; 15 out of 309 (4.8%) lymph nodes contained metastases; 9 out of 15 (60%) measured > 5 mm and were located on levels 2 and 5; and six, located on level 5, measured < 5 mm. The modified clearing technique is a quick, easy and reproducible method for identifying lymph nodes in post-irradiated surgical specimens. In comparison to the traditional manual method of searching for lymph nodes, it improves in the detection of small lymph nodes (< 5 mm), allowing better staging in patients with rectal adenocarcinoma." @default.
- W1520509538 created "2016-06-24" @default.
- W1520509538 creator A5043922747 @default.
- W1520509538 creator A5066344304 @default.
- W1520509538 creator A5066408505 @default.
- W1520509538 creator A5071490602 @default.
- W1520509538 creator A5085545268 @default.
- W1520509538 date "1996-01-01" @default.
- W1520509538 modified "2023-10-14" @default.
- W1520509538 title "Modified clearing technique to identify lymph node metastases in post-irradiated surgical specimens from rectal adenocarcinoma." @default.
- W1520509538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8867364" @default.
- W1520509538 hasPublicationYear "1996" @default.
- W1520509538 type Work @default.
- W1520509538 sameAs 1520509538 @default.
- W1520509538 citedByCount "10" @default.
- W1520509538 countsByYear W15205095382014 @default.
- W1520509538 crossrefType "journal-article" @default.
- W1520509538 hasAuthorship W1520509538A5043922747 @default.
- W1520509538 hasAuthorship W1520509538A5066344304 @default.
- W1520509538 hasAuthorship W1520509538A5066408505 @default.
- W1520509538 hasAuthorship W1520509538A5071490602 @default.
- W1520509538 hasAuthorship W1520509538A5085545268 @default.
- W1520509538 hasConcept C121608353 @default.
- W1520509538 hasConcept C126322002 @default.
- W1520509538 hasConcept C126838900 @default.
- W1520509538 hasConcept C141071460 @default.
- W1520509538 hasConcept C142724271 @default.
- W1520509538 hasConcept C146249460 @default.
- W1520509538 hasConcept C2779720271 @default.
- W1520509538 hasConcept C2780601773 @default.
- W1520509538 hasConcept C2780849966 @default.
- W1520509538 hasConcept C2781182431 @default.
- W1520509538 hasConcept C2908647359 @default.
- W1520509538 hasConcept C2989005 @default.
- W1520509538 hasConcept C71924100 @default.
- W1520509538 hasConcept C99454951 @default.
- W1520509538 hasConceptScore W1520509538C121608353 @default.
- W1520509538 hasConceptScore W1520509538C126322002 @default.
- W1520509538 hasConceptScore W1520509538C126838900 @default.
- W1520509538 hasConceptScore W1520509538C141071460 @default.
- W1520509538 hasConceptScore W1520509538C142724271 @default.
- W1520509538 hasConceptScore W1520509538C146249460 @default.
- W1520509538 hasConceptScore W1520509538C2779720271 @default.
- W1520509538 hasConceptScore W1520509538C2780601773 @default.
- W1520509538 hasConceptScore W1520509538C2780849966 @default.
- W1520509538 hasConceptScore W1520509538C2781182431 @default.
- W1520509538 hasConceptScore W1520509538C2908647359 @default.
- W1520509538 hasConceptScore W1520509538C2989005 @default.
- W1520509538 hasConceptScore W1520509538C71924100 @default.
- W1520509538 hasConceptScore W1520509538C99454951 @default.
- W1520509538 hasIssue "1" @default.
- W1520509538 hasLocation W15205095381 @default.
- W1520509538 hasOpenAccess W1520509538 @default.
- W1520509538 hasPrimaryLocation W15205095381 @default.
- W1520509538 hasRelatedWork W1975216695 @default.
- W1520509538 hasRelatedWork W1979771392 @default.
- W1520509538 hasRelatedWork W2036439935 @default.
- W1520509538 hasRelatedWork W2090868032 @default.
- W1520509538 hasRelatedWork W2158100070 @default.
- W1520509538 hasRelatedWork W2375173177 @default.
- W1520509538 hasRelatedWork W2409990855 @default.
- W1520509538 hasRelatedWork W2419031346 @default.
- W1520509538 hasRelatedWork W2473064702 @default.
- W1520509538 hasRelatedWork W3189360416 @default.
- W1520509538 hasVolume "27" @default.
- W1520509538 isParatext "false" @default.
- W1520509538 isRetracted "false" @default.
- W1520509538 magId "1520509538" @default.
- W1520509538 workType "article" @default.