FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520525371> ?p ?o ?g. }

• W1520525371 endingPage "1792" @default.
• W1520525371 startingPage "1787" @default.
• W1520525371 abstract "Growth activation of quiescent cells leads to enhanced low density lipoprotein (LDL) receptor expression at the cell surface. To determine the basis for this stimulated receptor activity, we measured LDL receptor activity, changes in receptor protein mass, and mRNA abundance in quiescent and growth-activated cultured human skin fibroblasts. Growth activation, using insulin or platelet-derived growth factor, led to dose-dependent increases in cellular LDL receptor mRNA level (average 5.2-fold increase at 10 ng/ml platelet-derived growth factor, 4.1-fold increase at 58 ng/ml insulin) and cell surface expression (average 3.5-fold increase at 10 ng/ml platelet-derived growth factor, 2.5-fold increase at 58 ng/ml insulin). Increased LDL receptor mRNA levels could be detected as early as 2 h after addition of growth factor (3.2-fold), whereas increased levels of LDL receptor binding and mass were not detected until after 4-8 h. Growth activation led to induction of LDL receptor gene transcription, led to induction of LDL receptor gene transcription, and the increase of LDL receptor mRNA produced by addition of growth factor was completely prevented by actinomycin D. These observations indicate that growth-related activation of the LDL receptor pathway is accounted for, primarily, by growth-activated enhancement of LDL receptor gene transcription." @default.
• W1520525371 created "2016-06-24" @default.
• W1520525371 creator A5007942356 @default.
• W1520525371 creator A5021558137 @default.
• W1520525371 creator A5034444153 @default.
• W1520525371 creator A5062468141 @default.
• W1520525371 creator A5071770587 @default.
• W1520525371 date "1989-01-01" @default.
• W1520525371 modified "2023-09-26" @default.
• W1520525371 title "Mechanism of the Growth-related Activation of the Low Density Lipoprotein Receptor Pathway" @default.
• W1520525371 cites W1489921015 @default.
• W1520525371 cites W1495163505 @default.
• W1520525371 cites W1498775324 @default.
• W1520525371 cites W1522459970 @default.
• W1520525371 cites W1535994471 @default.
• W1520525371 cites W1542484046 @default.
• W1520525371 cites W1549397399 @default.
• W1520525371 cites W1549703942 @default.
• W1520525371 cites W1568755186 @default.
• W1520525371 cites W1579140970 @default.
• W1520525371 cites W1580868642 @default.
• W1520525371 cites W1584205036 @default.
• W1520525371 cites W1589850719 @default.
• W1520525371 cites W1593160407 @default.
• W1520525371 cites W1600000166 @default.
• W1520525371 cites W1620258338 @default.
• W1520525371 cites W1631424226 @default.
• W1520525371 cites W1656775820 @default.
• W1520525371 cites W1775749144 @default.
• W1520525371 cites W1902852842 @default.
• W1520525371 cites W1969820681 @default.
• W1520525371 cites W1974755746 @default.
• W1520525371 cites W1980092242 @default.
• W1520525371 cites W1984461711 @default.
• W1520525371 cites W1995032745 @default.
• W1520525371 cites W1996917420 @default.
• W1520525371 cites W2001429874 @default.
• W1520525371 cites W2005971684 @default.
• W1520525371 cites W2021253208 @default.
• W1520525371 cites W2062067423 @default.
• W1520525371 cites W2072948302 @default.
• W1520525371 cites W2100300873 @default.
• W1520525371 cites W2108038378 @default.
• W1520525371 cites W2116153438 @default.
• W1520525371 cites W2156799866 @default.
• W1520525371 doi "https://doi.org/10.1016/s0021-9258(18)94256-0" @default.
• W1520525371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2643603" @default.
• W1520525371 hasPublicationYear "1989" @default.
• W1520525371 type Work @default.
• W1520525371 sameAs 1520525371 @default.
• W1520525371 citedByCount "55" @default.
• W1520525371 countsByYear W15205253712017 @default.
• W1520525371 countsByYear W15205253712019 @default.
• W1520525371 countsByYear W15205253712023 @default.
• W1520525371 crossrefType "journal-article" @default.
• W1520525371 hasAuthorship W1520525371A5007942356 @default.
• W1520525371 hasAuthorship W1520525371A5021558137 @default.
• W1520525371 hasAuthorship W1520525371A5034444153 @default.
• W1520525371 hasAuthorship W1520525371A5062468141 @default.
• W1520525371 hasAuthorship W1520525371A5071770587 @default.
• W1520525371 hasBestOaLocation W15205253711 @default.
• W1520525371 hasConcept C111472728 @default.
• W1520525371 hasConcept C12554922 @default.
• W1520525371 hasConcept C138885662 @default.
• W1520525371 hasConcept C170493617 @default.
• W1520525371 hasConcept C185592680 @default.
• W1520525371 hasConcept C2778163477 @default.
• W1520525371 hasConcept C2779620165 @default.
• W1520525371 hasConcept C2780072125 @default.
• W1520525371 hasConcept C43554185 @default.
• W1520525371 hasConcept C55493867 @default.
• W1520525371 hasConcept C86803240 @default.
• W1520525371 hasConcept C89611455 @default.
• W1520525371 hasConcept C95444343 @default.
• W1520525371 hasConceptScore W1520525371C111472728 @default.
• W1520525371 hasConceptScore W1520525371C12554922 @default.
• W1520525371 hasConceptScore W1520525371C138885662 @default.
• W1520525371 hasConceptScore W1520525371C170493617 @default.
• W1520525371 hasConceptScore W1520525371C185592680 @default.
• W1520525371 hasConceptScore W1520525371C2778163477 @default.
• W1520525371 hasConceptScore W1520525371C2779620165 @default.
• W1520525371 hasConceptScore W1520525371C2780072125 @default.
• W1520525371 hasConceptScore W1520525371C43554185 @default.
• W1520525371 hasConceptScore W1520525371C55493867 @default.
• W1520525371 hasConceptScore W1520525371C86803240 @default.
• W1520525371 hasConceptScore W1520525371C89611455 @default.
• W1520525371 hasConceptScore W1520525371C95444343 @default.
• W1520525371 hasIssue "3" @default.
• W1520525371 hasLocation W15205253711 @default.
• W1520525371 hasOpenAccess W1520525371 @default.
• W1520525371 hasPrimaryLocation W15205253711 @default.
• W1520525371 hasRelatedWork W1604616253 @default.
• W1520525371 hasRelatedWork W1812963099 @default.
• W1520525371 hasRelatedWork W2001938441 @default.
• W1520525371 hasRelatedWork W2038054558 @default.
• W1520525371 hasRelatedWork W2077160325 @default.
• W1520525371 hasRelatedWork W2087652827 @default.
• W1520525371 hasRelatedWork W2088132089 @default.

• next