FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520532856> ?p ?o ?g. }

• W1520532856 abstract "For the investigation of the protein-ubiquinone interaction in the succinate-cytochrome c reductase region of the bovine heart mitochondrial electron transport chain, a series of 5-alkyl-substituted ubiquinone derivatives (5-R-Q0C10) were synthesized and characterized. Syntheses of 5-ethyl-Q0C10, 5-propyl-Q0C10, 5-isopropyl-Q0C10, and 5-butyl-Q0C10, were archived through radical coupling reactions between 2,3-dimethoxy-6-decyl-1,4-benzoquinone (5-H-Q0C10) and the corresponding alkanoyl peroxides. Although the spectral and redox properties of 5-R-Q0C10 are very similar to those of 5-methyl-2,3 dimethoxy-6-decyl-1,4-benzoquinone, the biological electron transfer efficiencies of these derivatives differ significantly. The reducibility of these derivatives by succinate, as measured with succinate-Q reductase and the oxidizability as measured by ubiquinol-cytochrome c reductase, decreased as the size of the substituents increased. 5-Ethyl-Q0C10 has about 50% of the activity of 5-methyl-2,3-dimethoxy-6-decyl-1,4-benzoquinone, whereas molecules with 5-alkyl groups of three or more carbon atoms are virtually inactive as electron acceptors for succinate-Q reductase. Reduced form of the derivative with no substituent at the 5-position, 5-H derivative is more effectively oxidized by ubiquinol-cytochrome c reductase than does the 5-methyl derivative, the native form. The oxidation of 5-H derivative is in a concentration-dependent manner at low concentrations but exhibits a substrate inhibition at higher concentrations. No such substrate inhibition is observed when other 5-substituted Q derivatives are used. 5-H derivative is a better electron acceptor for succinate-Q reductase than any other Q derivatives and does not show substrate inhibition, even at high concentrations. These results indicate that the binding environment of the benzoquinone ring in succinate-Q reductase is more specific than that of ubiquinol-cytochrome c reductase." @default.
• W1520532856 created "2016-06-24" @default.
• W1520532856 creator A5013929528 @default.
• W1520532856 creator A5053397364 @default.
• W1520532856 creator A5008009314 @default.
• W1520532856 date "1994-11-01" @default.
• W1520532856 modified "2023-09-28" @default.
• W1520532856 title "Protein ubiquinone interaction. Synthesis and biological properties of 5-alkyl ubiquinone derivatives." @default.
• W1520532856 cites W1482087680 @default.
• W1520532856 cites W1497205192 @default.
• W1520532856 cites W1554679408 @default.
• W1520532856 cites W1580349070 @default.
• W1520532856 cites W1589039153 @default.
• W1520532856 cites W1605039001 @default.
• W1520532856 cites W1966728800 @default.
• W1520532856 cites W1983684626 @default.
• W1520532856 cites W1983935922 @default.
• W1520532856 cites W1988790330 @default.
• W1520532856 cites W1999943887 @default.
• W1520532856 cites W2003352425 @default.
• W1520532856 cites W2016992459 @default.
• W1520532856 cites W2033965578 @default.
• W1520532856 cites W2044305768 @default.
• W1520532856 cites W2044740646 @default.
• W1520532856 cites W2070603664 @default.
• W1520532856 cites W2070652728 @default.
• W1520532856 cites W2074778510 @default.
• W1520532856 cites W2091747608 @default.
• W1520532856 cites W2108436623 @default.
• W1520532856 cites W3085336325 @default.
• W1520532856 cites W3120337791 @default.
• W1520532856 cites W4253238409 @default.
• W1520532856 doi "https://doi.org/10.1016/s0021-9258(18)46869-x" @default.
• W1520532856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7961719" @default.
• W1520532856 hasPublicationYear "1994" @default.
• W1520532856 type Work @default.
• W1520532856 sameAs 1520532856 @default.
• W1520532856 citedByCount "5" @default.
• W1520532856 countsByYear W15205328562020 @default.
• W1520532856 crossrefType "journal-article" @default.
• W1520532856 hasAuthorship W1520532856A5008009314 @default.
• W1520532856 hasAuthorship W1520532856A5013929528 @default.
• W1520532856 hasAuthorship W1520532856A5053397364 @default.
• W1520532856 hasBestOaLocation W15205328561 @default.
• W1520532856 hasConcept C104292427 @default.
• W1520532856 hasConcept C104317684 @default.
• W1520532856 hasConcept C111368507 @default.
• W1520532856 hasConcept C127313418 @default.
• W1520532856 hasConcept C134651460 @default.
• W1520532856 hasConcept C14471203 @default.
• W1520532856 hasConcept C155647269 @default.
• W1520532856 hasConcept C178790620 @default.
• W1520532856 hasConcept C181199279 @default.
• W1520532856 hasConcept C185592680 @default.
• W1520532856 hasConcept C24840226 @default.
• W1520532856 hasConcept C2776319529 @default.
• W1520532856 hasConcept C2777289219 @default.
• W1520532856 hasConcept C2778689049 @default.
• W1520532856 hasConcept C2778777121 @default.
• W1520532856 hasConcept C2779686393 @default.
• W1520532856 hasConcept C2780263894 @default.
• W1520532856 hasConcept C2780768313 @default.
• W1520532856 hasConcept C28859421 @default.
• W1520532856 hasConcept C29311851 @default.
• W1520532856 hasConcept C55493867 @default.
• W1520532856 hasConcept C55904794 @default.
• W1520532856 hasConcept C71240020 @default.
• W1520532856 hasConceptScore W1520532856C104292427 @default.
• W1520532856 hasConceptScore W1520532856C104317684 @default.
• W1520532856 hasConceptScore W1520532856C111368507 @default.
• W1520532856 hasConceptScore W1520532856C127313418 @default.
• W1520532856 hasConceptScore W1520532856C134651460 @default.
• W1520532856 hasConceptScore W1520532856C14471203 @default.
• W1520532856 hasConceptScore W1520532856C155647269 @default.
• W1520532856 hasConceptScore W1520532856C178790620 @default.
• W1520532856 hasConceptScore W1520532856C181199279 @default.
• W1520532856 hasConceptScore W1520532856C185592680 @default.
• W1520532856 hasConceptScore W1520532856C24840226 @default.
• W1520532856 hasConceptScore W1520532856C2776319529 @default.
• W1520532856 hasConceptScore W1520532856C2777289219 @default.
• W1520532856 hasConceptScore W1520532856C2778689049 @default.
• W1520532856 hasConceptScore W1520532856C2778777121 @default.
• W1520532856 hasConceptScore W1520532856C2779686393 @default.
• W1520532856 hasConceptScore W1520532856C2780263894 @default.
• W1520532856 hasConceptScore W1520532856C2780768313 @default.
• W1520532856 hasConceptScore W1520532856C28859421 @default.
• W1520532856 hasConceptScore W1520532856C29311851 @default.
• W1520532856 hasConceptScore W1520532856C55493867 @default.
• W1520532856 hasConceptScore W1520532856C55904794 @default.
• W1520532856 hasConceptScore W1520532856C71240020 @default.
• W1520532856 hasLocation W15205328561 @default.
• W1520532856 hasOpenAccess W1520532856 @default.
• W1520532856 hasPrimaryLocation W15205328561 @default.
• W1520532856 hasRelatedWork W1513419693 @default.
• W1520532856 hasRelatedWork W1548579375 @default.
• W1520532856 hasRelatedWork W1576054453 @default.
• W1520532856 hasRelatedWork W1965800744 @default.
• W1520532856 hasRelatedWork W1988853058 @default.
• W1520532856 hasRelatedWork W2009182559 @default.
• W1520532856 hasRelatedWork W2011867618 @default.

• next