FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520542863> ?p ?o ?g. }

• W1520542863 endingPage "320" @default.
• W1520542863 startingPage "314" @default.
• W1520542863 abstract "Recent studies have shown that rats and mice maintained on a dietary restriction (DR) regimen exhibit increased resistance of neurons to excitotoxic, oxidative, and metabolic insults in experimental models of Alzheimer's, Parkinson's, and Huntington's diseases and stroke. Because synaptic terminals are sites where the neurodegenerative process may begin in such neurodegenerative disorders, we determined the effects of DR on synaptic homeostasis and vulnerability to oxidative and metabolic insults. Basal levels of glucose uptake were similar in cerebral cortical synaptosomes from rats maintained on DR for 3 months compared with synaptosomes from rats fed ad libitum. Exposure of synaptosomes to oxidative insults (amyloid beta-peptide and Fe(2+)) and a metabolic insult (the mitochondrial toxin 3-nitropropionic acid) resulted in decreased levels of glucose uptake. Impairment of glucose uptake following oxidative and metabolic insults was significantly attenuated in synaptosomes from rats maintained on DR. DR was also effective in protecting synaptosomes against oxidative and metabolic impairment of glutamate uptake. Loss of mitochondrial function caused by oxidative and metabolic insults, as indicated by increased levels of reactive oxygen species and decreased transmembrane potential, was significantly attenuated in synaptosomes from rats maintained on DR. Levels of the stress proteins HSP-70 and GRP-78 were increased in synaptosomes from DR rats, consistent with previous data suggesting that the neuroprotective mechanism of DR involves a preconditioning effect. Collectively, our data provide the first evidence that DR can alter synaptic homeostasis in a manner that enhances the ability of synapses to withstand adversity." @default.
• W1520542863 created "2016-06-24" @default.
• W1520542863 creator A5004024175 @default.
• W1520542863 creator A5068354292 @default.
• W1520542863 creator A5074480604 @default.
• W1520542863 creator A5083040475 @default.
• W1520542863 date "2001-12-25" @default.
• W1520542863 modified "2023-09-23" @default.
• W1520542863 title "Beneficial Effects of Dietary Restriction on Cerebral Cortical Synaptic Terminals" @default.
• W1520542863 cites W1675038283 @default.
• W1520542863 cites W1762207349 @default.
• W1520542863 cites W1830456158 @default.
• W1520542863 cites W1964784067 @default.
• W1520542863 cites W1966780327 @default.
• W1520542863 cites W1978874104 @default.
• W1520542863 cites W1982647833 @default.
• W1520542863 cites W1984098639 @default.
• W1520542863 cites W1985525810 @default.
• W1520542863 cites W1988106461 @default.
• W1520542863 cites W2006388911 @default.
• W1520542863 cites W2013486761 @default.
• W1520542863 cites W2014701370 @default.
• W1520542863 cites W2020318455 @default.
• W1520542863 cites W2027395393 @default.
• W1520542863 cites W2028746054 @default.
• W1520542863 cites W2037024392 @default.
• W1520542863 cites W2037156529 @default.
• W1520542863 cites W2039954548 @default.
• W1520542863 cites W2046639009 @default.
• W1520542863 cites W2049876394 @default.
• W1520542863 cites W2050523782 @default.
• W1520542863 cites W2057938774 @default.
• W1520542863 cites W2058319618 @default.
• W1520542863 cites W2067072091 @default.
• W1520542863 cites W2068369700 @default.
• W1520542863 cites W2069303994 @default.
• W1520542863 cites W2069787626 @default.
• W1520542863 cites W2072704848 @default.
• W1520542863 cites W2077986315 @default.
• W1520542863 cites W2082468639 @default.
• W1520542863 cites W2084639084 @default.
• W1520542863 cites W2088514704 @default.
• W1520542863 cites W2090013017 @default.
• W1520542863 cites W2090313884 @default.
• W1520542863 cites W2090686203 @default.
• W1520542863 cites W2091427713 @default.
• W1520542863 cites W2099816146 @default.
• W1520542863 cites W2111972716 @default.
• W1520542863 cites W2117104323 @default.
• W1520542863 cites W2120648922 @default.
• W1520542863 cites W2120690437 @default.
• W1520542863 cites W2128002200 @default.
• W1520542863 cites W2143579765 @default.
• W1520542863 cites W2144232114 @default.
• W1520542863 cites W2147464247 @default.
• W1520542863 cites W2154616390 @default.
• W1520542863 cites W2155255686 @default.
• W1520542863 cites W2155747798 @default.
• W1520542863 cites W2162188475 @default.
• W1520542863 cites W2162925265 @default.
• W1520542863 cites W2275229952 @default.
• W1520542863 cites W2329380932 @default.
• W1520542863 cites W2331110091 @default.
• W1520542863 cites W4246806002 @default.
• W1520542863 cites W4361773848 @default.
• W1520542863 doi "https://doi.org/10.1046/j.1471-4159.2000.0750314.x" @default.
• W1520542863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10854276" @default.
• W1520542863 hasPublicationYear "2001" @default.
• W1520542863 type Work @default.
• W1520542863 sameAs 1520542863 @default.
• W1520542863 citedByCount "103" @default.
• W1520542863 countsByYear W15205428632012 @default.
• W1520542863 countsByYear W15205428632013 @default.
• W1520542863 countsByYear W15205428632014 @default.
• W1520542863 countsByYear W15205428632015 @default.
• W1520542863 countsByYear W15205428632016 @default.
• W1520542863 countsByYear W15205428632018 @default.
• W1520542863 countsByYear W15205428632019 @default.
• W1520542863 countsByYear W15205428632020 @default.
• W1520542863 countsByYear W15205428632021 @default.
• W1520542863 countsByYear W15205428632022 @default.
• W1520542863 countsByYear W15205428632023 @default.
• W1520542863 crossrefType "journal-article" @default.
• W1520542863 hasAuthorship W1520542863A5004024175 @default.
• W1520542863 hasAuthorship W1520542863A5068354292 @default.
• W1520542863 hasAuthorship W1520542863A5074480604 @default.
• W1520542863 hasAuthorship W1520542863A5083040475 @default.
• W1520542863 hasConcept C126322002 @default.
• W1520542863 hasConcept C134018914 @default.
• W1520542863 hasConcept C170493617 @default.
• W1520542863 hasConcept C185592680 @default.
• W1520542863 hasConcept C25498285 @default.
• W1520542863 hasConcept C2776151105 @default.
• W1520542863 hasConcept C2778921374 @default.
• W1520542863 hasConcept C2781012912 @default.
• W1520542863 hasConcept C48349386 @default.
• W1520542863 hasConcept C529278444 @default.
• W1520542863 hasConcept C55493867 @default.

• next