Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520551877> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1520551877 abstract "Anemia is common in sub-Saharan African infants, particularly in the context of HIV infection. Hepcidin is the major hormone regulating iron metabolism but its role in the pathogenesis of anemia during infancy is unclear. The aim of this study was to characterize hepcidin concentrations in anemic and non-anemic infants and in HIV-infected and HIV-exposed uninfected (HEU) infants. Archived plasma samples from HIV-unexposed (n=289), HIV-exposed uninfected (HEU; n=354) and HIV-infected (n=264) anemic and non-anemic Zimbabwean infants at 3, 6 and 12mo of age were used to measure hepcidin, ferritin, transferrin receptor, AGP and CRP by ELISA. We undertook multivariate analysis of hepcidin, HIV and anemia status, adjusting for sex and age. Hepcidin concentrations were higher in HIV-infected compared to HEU and HIV-unexposed groups throughout infancy and higher in HEU compared to HIV-unexposed infants. Hepcidin concentrations were correlated with levels of ferritin and CRP. Overall, anemia was not associated with hepcidin concentrations during infancy, except in HIV-unexposed infants. Hepcidin declined with age in all groups; girls had higher hepcidin concentrations than boys. Plasma hepcidin concentrations are positively associated with inflammation in infants, as has been shown in adults. Future studies should explore whether elevated hepcidin contributes to the pathogenesis of HIV infection. Grant Funding Source: Supported by the Bill and Melinda Gates Foundation (OPP1021542); Department for International Develo" @default.
- W1520551877 created "2016-06-24" @default.
- W1520551877 creator A5018295551 @default.
- W1520551877 creator A5024319683 @default.
- W1520551877 creator A5041072379 @default.
- W1520551877 creator A5062287673 @default.
- W1520551877 creator A5066929615 @default.
- W1520551877 creator A5089285208 @default.
- W1520551877 date "2014-04-01" @default.
- W1520551877 modified "2023-09-27" @default.
- W1520551877 title "The role of hepcidin in the pathogenesis of anemia in Zimbabwean infants (1034.1)" @default.
- W1520551877 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1034.1" @default.
- W1520551877 hasPublicationYear "2014" @default.
- W1520551877 type Work @default.
- W1520551877 sameAs 1520551877 @default.
- W1520551877 citedByCount "0" @default.
- W1520551877 crossrefType "journal-article" @default.
- W1520551877 hasAuthorship W1520551877A5018295551 @default.
- W1520551877 hasAuthorship W1520551877A5024319683 @default.
- W1520551877 hasAuthorship W1520551877A5041072379 @default.
- W1520551877 hasAuthorship W1520551877A5062287673 @default.
- W1520551877 hasAuthorship W1520551877A5066929615 @default.
- W1520551877 hasAuthorship W1520551877A5089285208 @default.
- W1520551877 hasConcept C126322002 @default.
- W1520551877 hasConcept C151730666 @default.
- W1520551877 hasConcept C203014093 @default.
- W1520551877 hasConcept C2776768029 @default.
- W1520551877 hasConcept C2778248108 @default.
- W1520551877 hasConcept C2778319317 @default.
- W1520551877 hasConcept C2779343474 @default.
- W1520551877 hasConcept C2780942790 @default.
- W1520551877 hasConcept C42407357 @default.
- W1520551877 hasConcept C71924100 @default.
- W1520551877 hasConcept C86803240 @default.
- W1520551877 hasConceptScore W1520551877C126322002 @default.
- W1520551877 hasConceptScore W1520551877C151730666 @default.
- W1520551877 hasConceptScore W1520551877C203014093 @default.
- W1520551877 hasConceptScore W1520551877C2776768029 @default.
- W1520551877 hasConceptScore W1520551877C2778248108 @default.
- W1520551877 hasConceptScore W1520551877C2778319317 @default.
- W1520551877 hasConceptScore W1520551877C2779343474 @default.
- W1520551877 hasConceptScore W1520551877C2780942790 @default.
- W1520551877 hasConceptScore W1520551877C42407357 @default.
- W1520551877 hasConceptScore W1520551877C71924100 @default.
- W1520551877 hasConceptScore W1520551877C86803240 @default.
- W1520551877 hasFunder F4320306137 @default.
- W1520551877 hasIssue "S1" @default.
- W1520551877 hasLocation W15205518771 @default.
- W1520551877 hasOpenAccess W1520551877 @default.
- W1520551877 hasPrimaryLocation W15205518771 @default.
- W1520551877 hasRelatedWork W1983160892 @default.
- W1520551877 hasRelatedWork W2002538758 @default.
- W1520551877 hasRelatedWork W2006579028 @default.
- W1520551877 hasRelatedWork W2157754403 @default.
- W1520551877 hasRelatedWork W2802402729 @default.
- W1520551877 hasRelatedWork W2960153845 @default.
- W1520551877 hasRelatedWork W3201398360 @default.
- W1520551877 hasRelatedWork W3208654500 @default.
- W1520551877 hasRelatedWork W4320709700 @default.
- W1520551877 hasRelatedWork W79960305 @default.
- W1520551877 hasVolume "28" @default.
- W1520551877 isParatext "false" @default.
- W1520551877 isRetracted "false" @default.
- W1520551877 magId "1520551877" @default.
- W1520551877 workType "article" @default.