FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520576677> ?p ?o ?g. }

• W1520576677 abstract "Peripheral arterial disease (PAD) is common among elderly and affects about 20% of the population above the age of 60 years. PAD is a strong marker for future cardiovascular events and increased mortality due to widespread atherosclerotic lesions in the coronary and cerebral arteries. Intermittent claudication (IC) with lower extremity pain on walking has a prevalence of 3-6 % in men at the age of 60-70 years according to large population studies. Among these patients the majority remain stable without progression of symptoms. The symptoms progress in about 25% of the patients and distal ulceration or gangrene and ischemic rest pain, i.e critical limb ischemia (CLI) develops. Despite liberal indications for surgical or endovascular revascularizations, major amputation is required in as much as one third of the patients with CLI and for these patients there is a great need for alternative treatment strategies. Collateral development, bridging stenoses or occlusions, is one of the reparative processes that reduce the consequences of coronary artery disease and PAD. The growth of these collaterals from preexisting arteriole is called arteriogenesis. Angiogenesis, the sprouting of new capillaries, may also be of importance in the pathophysiology of PAD. There is little data establishing any impact of angiogenesis on PAD but it is likely that an angiogenic process occurs in ischemic tissues as a response to acute ischemia. Accordingly, hemodynamic forces, cytokines and inflammatory processes appear to be of importance in arteriogenesis, but the exact role of these processes is not firmly established. The arteriogenic mechanisms studied in animal models of limb ischemia and in vitro models aiming to stimulate arteriogenesis by supplying vascular growth factors have shown promising results. The aim of this thesis was to assess the role of vascular growth factors in the arteriogenic process in PAD patients, and furthermore to evaluate gene therapy of FGF-4 in an animal model and humans as a method for therapeutic arteriogenesis. First we explored the expression of growth factors in skin and muscle samples from 25 patients with CLI. There were increased levels of FGF-2 but not VEGF in distal muscle compared to proximal. Furthermore the expression of growth factors and inflammatory cytokines was investigated in 20 patients with IC after walking provocation. The pro-inflammatory cytokine IL-6 was significantly elevated one hour after exercise. VEGF mRNA also increased significantly in ischemic muscle samples after exercise. Taken together these results indicate that VEGF expression rises locally in response to maximal exercise to the absolute limit of pain in patients with IC but not in patients with CLI at rest. FGF-2 seems to be upregulated in distal muscle in CLI patients which could be due to local inflammatory processes. Gene therapy with adenovirus mediated FGF-4 was assessed in a rat model of severe limb ischemia and in a phase I/II multicenter clinical trial in CLI patients. No signs of stimulated arteriogenesis were detected in the animal model 4 weeks after gene transfer. Gene therapy in 13 patients seemed safe, but no sign of stimulated arteriogenesis was able to be detected in this small patient cohort." @default.
• W1520576677 created "2016-06-24" @default.
• W1520576677 creator A5004894413 @default.
• W1520576677 date "2006-02-03" @default.
• W1520576677 modified "2023-09-28" @default.
• W1520576677 title "Collateral development in limb ischemia : Aspects of endogenous and stimulated arteriogenesis" @default.
• W1520576677 cites W1495287184 @default.
• W1520576677 cites W154322005 @default.
• W1520576677 cites W1556818178 @default.
• W1520576677 cites W1580052517 @default.
• W1520576677 cites W1679229092 @default.
• W1520576677 cites W1787069486 @default.
• W1520576677 cites W1840506659 @default.
• W1520576677 cites W1877068067 @default.
• W1520576677 cites W1916462087 @default.
• W1520576677 cites W1949173079 @default.
• W1520576677 cites W1961157115 @default.
• W1520576677 cites W1963782920 @default.
• W1520576677 cites W1968750351 @default.
• W1520576677 cites W1970017835 @default.
• W1520576677 cites W1970909475 @default.
• W1520576677 cites W1973825109 @default.
• W1520576677 cites W1974472434 @default.
• W1520576677 cites W1974812650 @default.
• W1520576677 cites W1975361512 @default.
• W1520576677 cites W1975519085 @default.
• W1520576677 cites W1975818941 @default.
• W1520576677 cites W1977172298 @default.
• W1520576677 cites W1978021555 @default.
• W1520576677 cites W1978859651 @default.
• W1520576677 cites W1978935536 @default.
• W1520576677 cites W1978996858 @default.
• W1520576677 cites W1979153251 @default.
• W1520576677 cites W1981237781 @default.
• W1520576677 cites W1987399881 @default.
• W1520576677 cites W1987466174 @default.
• W1520576677 cites W1988157428 @default.
• W1520576677 cites W1988688040 @default.
• W1520576677 cites W1989325386 @default.
• W1520576677 cites W1989467384 @default.
• W1520576677 cites W1989769687 @default.
• W1520576677 cites W1989839576 @default.
• W1520576677 cites W1996734641 @default.
• W1520576677 cites W1999579644 @default.
• W1520576677 cites W2000292756 @default.
• W1520576677 cites W2000537146 @default.
• W1520576677 cites W2000823175 @default.
• W1520576677 cites W2002422939 @default.
• W1520576677 cites W2002593980 @default.
• W1520576677 cites W2002806231 @default.
• W1520576677 cites W2005345468 @default.
• W1520576677 cites W2005469488 @default.
• W1520576677 cites W2005971799 @default.
• W1520576677 cites W2008940139 @default.
• W1520576677 cites W2011488848 @default.
• W1520576677 cites W2012851453 @default.
• W1520576677 cites W2014368942 @default.
• W1520576677 cites W2014519464 @default.
• W1520576677 cites W2017176305 @default.
• W1520576677 cites W20186660 @default.
• W1520576677 cites W2019403939 @default.
• W1520576677 cites W2019555687 @default.
• W1520576677 cites W2021193012 @default.
• W1520576677 cites W2021513166 @default.
• W1520576677 cites W2022865983 @default.
• W1520576677 cites W2025009296 @default.
• W1520576677 cites W2025173623 @default.
• W1520576677 cites W2028018397 @default.
• W1520576677 cites W2028020540 @default.
• W1520576677 cites W2028383668 @default.
• W1520576677 cites W2029008879 @default.
• W1520576677 cites W2029536812 @default.
• W1520576677 cites W2030008253 @default.
• W1520576677 cites W2030955277 @default.
• W1520576677 cites W2033390204 @default.
• W1520576677 cites W2035395950 @default.
• W1520576677 cites W2036324226 @default.
• W1520576677 cites W2037349803 @default.
• W1520576677 cites W2038473729 @default.
• W1520576677 cites W2038580857 @default.
• W1520576677 cites W2039222035 @default.
• W1520576677 cites W2039790484 @default.
• W1520576677 cites W2040155238 @default.
• W1520576677 cites W2048051408 @default.
• W1520576677 cites W2048258494 @default.
• W1520576677 cites W2049827480 @default.
• W1520576677 cites W2050358495 @default.
• W1520576677 cites W2052863747 @default.
• W1520576677 cites W2053704719 @default.
• W1520576677 cites W2054151200 @default.
• W1520576677 cites W2054629742 @default.
• W1520576677 cites W2055037877 @default.
• W1520576677 cites W2059259850 @default.
• W1520576677 cites W2060100969 @default.
• W1520576677 cites W2061149882 @default.
• W1520576677 cites W2062199188 @default.
• W1520576677 cites W2063570574 @default.
• W1520576677 cites W2064090125 @default.
• W1520576677 cites W2066963386 @default.
• W1520576677 cites W2067416354 @default.

• next