Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520578745> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1520578745 endingPage "652" @default.
- W1520578745 startingPage "647" @default.
- W1520578745 abstract "The optimisation and scale-up of a specific protein production process have to take into account cultivation conditions as well as cell physiology of growth and the influence of foreign protein expression on host cell metabolism. The ability of Zygosaccharomyces bailii to tolerate high sugar concentrations as well as high temperatures and acidic environments renders this “non-conventional” yeast suitable for the development of biotechnological processes like heterologous protein production. This work addresses the production of human interleukin-1β by a recombinant Z. bailii strain. We found that the heterologous protein production causes some modifications of the Z. bailii carbon metabolism, leading to a reduced biomass yield. The other important factor is the dependence of the recombinant IL-1β production/secretion on the growth rate. Among the cultivation strategies studied, the most appropriate in terms of production and productivity was the fed-batch mode." @default.
- W1520578745 created "2016-06-24" @default.
- W1520578745 creator A5010463563 @default.
- W1520578745 creator A5028962045 @default.
- W1520578745 creator A5031977359 @default.
- W1520578745 creator A5051377245 @default.
- W1520578745 creator A5080110200 @default.
- W1520578745 creator A5089743715 @default.
- W1520578745 date "2005-04-01" @default.
- W1520578745 modified "2023-09-23" @default.
- W1520578745 title "Heterologous protein production in : physiological effects and fermentative strategies" @default.
- W1520578745 cites W1875100849 @default.
- W1520578745 cites W1984044253 @default.
- W1520578745 cites W1993355579 @default.
- W1520578745 cites W2001941303 @default.
- W1520578745 cites W2034309871 @default.
- W1520578745 cites W2050782764 @default.
- W1520578745 cites W2074506489 @default.
- W1520578745 cites W2075124178 @default.
- W1520578745 cites W2080559648 @default.
- W1520578745 cites W2089312229 @default.
- W1520578745 cites W2101442503 @default.
- W1520578745 cites W2109093136 @default.
- W1520578745 cites W2114711411 @default.
- W1520578745 cites W2123380574 @default.
- W1520578745 cites W2123474055 @default.
- W1520578745 cites W2132537581 @default.
- W1520578745 cites W2135951486 @default.
- W1520578745 cites W2143390979 @default.
- W1520578745 cites W2148325536 @default.
- W1520578745 cites W2166265105 @default.
- W1520578745 cites W971382953 @default.
- W1520578745 doi "https://doi.org/10.1016/j.femsyr.2004.11.006" @default.
- W1520578745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15780664" @default.
- W1520578745 hasPublicationYear "2005" @default.
- W1520578745 type Work @default.
- W1520578745 sameAs 1520578745 @default.
- W1520578745 citedByCount "21" @default.
- W1520578745 countsByYear W15205787452012 @default.
- W1520578745 countsByYear W15205787452014 @default.
- W1520578745 countsByYear W15205787452015 @default.
- W1520578745 countsByYear W15205787452016 @default.
- W1520578745 countsByYear W15205787452017 @default.
- W1520578745 countsByYear W15205787452019 @default.
- W1520578745 countsByYear W15205787452021 @default.
- W1520578745 countsByYear W15205787452022 @default.
- W1520578745 crossrefType "journal-article" @default.
- W1520578745 hasAuthorship W1520578745A5010463563 @default.
- W1520578745 hasAuthorship W1520578745A5028962045 @default.
- W1520578745 hasAuthorship W1520578745A5031977359 @default.
- W1520578745 hasAuthorship W1520578745A5051377245 @default.
- W1520578745 hasAuthorship W1520578745A5080110200 @default.
- W1520578745 hasAuthorship W1520578745A5089743715 @default.
- W1520578745 hasBestOaLocation W15205787451 @default.
- W1520578745 hasConcept C100544194 @default.
- W1520578745 hasConcept C104317684 @default.
- W1520578745 hasConcept C115540264 @default.
- W1520578745 hasConcept C150903083 @default.
- W1520578745 hasConcept C18903297 @default.
- W1520578745 hasConcept C2777108408 @default.
- W1520578745 hasConcept C2779222958 @default.
- W1520578745 hasConcept C2780115692 @default.
- W1520578745 hasConcept C55493867 @default.
- W1520578745 hasConcept C86803240 @default.
- W1520578745 hasConceptScore W1520578745C100544194 @default.
- W1520578745 hasConceptScore W1520578745C104317684 @default.
- W1520578745 hasConceptScore W1520578745C115540264 @default.
- W1520578745 hasConceptScore W1520578745C150903083 @default.
- W1520578745 hasConceptScore W1520578745C18903297 @default.
- W1520578745 hasConceptScore W1520578745C2777108408 @default.
- W1520578745 hasConceptScore W1520578745C2779222958 @default.
- W1520578745 hasConceptScore W1520578745C2780115692 @default.
- W1520578745 hasConceptScore W1520578745C55493867 @default.
- W1520578745 hasConceptScore W1520578745C86803240 @default.
- W1520578745 hasIssue "6-7" @default.
- W1520578745 hasLocation W15205787451 @default.
- W1520578745 hasLocation W15205787452 @default.
- W1520578745 hasOpenAccess W1520578745 @default.
- W1520578745 hasPrimaryLocation W15205787451 @default.
- W1520578745 hasRelatedWork W2035300983 @default.
- W1520578745 hasRelatedWork W2068698179 @default.
- W1520578745 hasRelatedWork W2078525576 @default.
- W1520578745 hasRelatedWork W2386333437 @default.
- W1520578745 hasRelatedWork W2394054727 @default.
- W1520578745 hasRelatedWork W2560634111 @default.
- W1520578745 hasRelatedWork W3174477451 @default.
- W1520578745 hasRelatedWork W3200968480 @default.
- W1520578745 hasRelatedWork W3211613485 @default.
- W1520578745 hasRelatedWork W3213985792 @default.
- W1520578745 hasVolume "5" @default.
- W1520578745 isParatext "false" @default.
- W1520578745 isRetracted "false" @default.
- W1520578745 magId "1520578745" @default.
- W1520578745 workType "article" @default.