Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520589624> ?p ?o ?g. }
- W1520589624 endingPage "1578" @default.
- W1520589624 startingPage "1568" @default.
- W1520589624 abstract "Abstract While considerable research has examined diminished insulin responses within peripheral tissues, comparatively little has been done to examine the effects of this metabolic disruption upon the CNS. The present study employed biochemical and electrophysiological assays of acutely prepared brain slices to determine whether neural insulin resistance is a component of the metabolic syndrome observed within the fructose‐fed (FF) hamster. The tyrosine phosphorylation levels of the insulin receptor (IR) and insulin receptor substrate 1 (IRS‐1) in response to insulin were significantly reduced within FF hamsters. Also, insulin‐mediated phosphorylation of both residues necessary for activation of the serine‐threonine kinase Akt/PKB, a key effector of insulin signaling, was markedly decreased. Elevated levels of the protein tyrosine phosphatase 1B, which dephosphorylates the IR and IRS‐1, were also observed within the cerebral cortex and hippocampus of FF hamsters. Examination of whether a nutritionally induced compromise of neural insulin signaling altered synaptic function revealed a significant attenuation of insulin‐induced long‐term depression, but no effect upon either paired‐pulse facilitation or electrically induced long‐term potentiation. Collectively, our results demonstrate, for the first time, that nutritionally induced insulin resistance significantly affects the neural insulin signaling pathway, and suggest that brain insulin resistance may contribute to cognitive impairment." @default.
- W1520589624 created "2016-06-24" @default.
- W1520589624 creator A5004578406 @default.
- W1520589624 creator A5017431210 @default.
- W1520589624 creator A5030295153 @default.
- W1520589624 creator A5047476496 @default.
- W1520589624 creator A5071773009 @default.
- W1520589624 creator A5074621440 @default.
- W1520589624 creator A5081208871 @default.
- W1520589624 date "2005-05-16" @default.
- W1520589624 modified "2023-10-13" @default.
- W1520589624 title "A biochemical and functional characterization of diet‐induced brain insulin resistance" @default.
- W1520589624 cites W1496740734 @default.
- W1520589624 cites W150222691 @default.
- W1520589624 cites W1557933310 @default.
- W1520589624 cites W1570789308 @default.
- W1520589624 cites W1572009433 @default.
- W1520589624 cites W1590273686 @default.
- W1520589624 cites W1590528461 @default.
- W1520589624 cites W1596652845 @default.
- W1520589624 cites W1627446849 @default.
- W1520589624 cites W1903272649 @default.
- W1520589624 cites W1908031530 @default.
- W1520589624 cites W1908445283 @default.
- W1520589624 cites W1966215066 @default.
- W1520589624 cites W1974588388 @default.
- W1520589624 cites W1976854271 @default.
- W1520589624 cites W1979373772 @default.
- W1520589624 cites W1980515872 @default.
- W1520589624 cites W1986519087 @default.
- W1520589624 cites W1987522063 @default.
- W1520589624 cites W1991202400 @default.
- W1520589624 cites W1992431456 @default.
- W1520589624 cites W2005955483 @default.
- W1520589624 cites W2006851823 @default.
- W1520589624 cites W2007551386 @default.
- W1520589624 cites W2012655679 @default.
- W1520589624 cites W2012741873 @default.
- W1520589624 cites W2012785062 @default.
- W1520589624 cites W2013952491 @default.
- W1520589624 cites W2014967694 @default.
- W1520589624 cites W2016425872 @default.
- W1520589624 cites W2024977010 @default.
- W1520589624 cites W2028212562 @default.
- W1520589624 cites W2035825704 @default.
- W1520589624 cites W2036284058 @default.
- W1520589624 cites W2040539334 @default.
- W1520589624 cites W2043868386 @default.
- W1520589624 cites W2049207423 @default.
- W1520589624 cites W2049871798 @default.
- W1520589624 cites W2051378734 @default.
- W1520589624 cites W2051993731 @default.
- W1520589624 cites W2054543840 @default.
- W1520589624 cites W2056030232 @default.
- W1520589624 cites W2056424732 @default.
- W1520589624 cites W2064298888 @default.
- W1520589624 cites W2067096633 @default.
- W1520589624 cites W2069069354 @default.
- W1520589624 cites W2070119291 @default.
- W1520589624 cites W2083636435 @default.
- W1520589624 cites W2083775524 @default.
- W1520589624 cites W2087444289 @default.
- W1520589624 cites W2087721441 @default.
- W1520589624 cites W2087772388 @default.
- W1520589624 cites W2092271417 @default.
- W1520589624 cites W2098743881 @default.
- W1520589624 cites W2107406042 @default.
- W1520589624 cites W2112927743 @default.
- W1520589624 cites W2114911095 @default.
- W1520589624 cites W2120447295 @default.
- W1520589624 cites W2130042602 @default.
- W1520589624 cites W2135896596 @default.
- W1520589624 cites W2138391708 @default.
- W1520589624 cites W2141680511 @default.
- W1520589624 cites W2141998004 @default.
- W1520589624 cites W2144690563 @default.
- W1520589624 cites W2145451941 @default.
- W1520589624 cites W2147067379 @default.
- W1520589624 cites W2147114673 @default.
- W1520589624 cites W2148389554 @default.
- W1520589624 cites W2161025366 @default.
- W1520589624 cites W2171814772 @default.
- W1520589624 cites W2315127326 @default.
- W1520589624 cites W4247176691 @default.
- W1520589624 cites W4253418569 @default.
- W1520589624 cites W4381322599 @default.
- W1520589624 doi "https://doi.org/10.1111/j.1471-4159.2005.03155.x" @default.
- W1520589624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15935073" @default.
- W1520589624 hasPublicationYear "2005" @default.
- W1520589624 type Work @default.
- W1520589624 sameAs 1520589624 @default.
- W1520589624 citedByCount "168" @default.
- W1520589624 countsByYear W15205896242012 @default.
- W1520589624 countsByYear W15205896242013 @default.
- W1520589624 countsByYear W15205896242014 @default.
- W1520589624 countsByYear W15205896242015 @default.
- W1520589624 countsByYear W15205896242016 @default.
- W1520589624 countsByYear W15205896242017 @default.