Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520592037> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1520592037 endingPage "2138" @default.
- W1520592037 startingPage "2132" @default.
- W1520592037 abstract "Abstract Murine acquired immunodeficiency syndrome (MAIDS) is a fatal disease induced by a mixture of retroviruses known as BM5. It is characterized by splenomegaly, lymphadenopathy, hypergammaglobulinemia, loss of T and B cell function, and development of B cell lymphomas. As the disease progresses, by wk 8 of infection, CD4 T cell response to Ags and mitogens is severely curtailed and the CD4 T cell population becomes anergic. We examined responses of anergic CD4 T cells upon addition of a costimulatory signal (anti-CD28) and a cytokine (IL-12), which might help to restore the function of cells. We report that proliferation and cytokine production were restored in the early stages of infection by the strategies we tested, but not at later stages when anergy was well established. We also examined the effect of the same treatments on anergy of CD4 T cells from thymectomized, BM5-infected mice to determine whether the rescue seen was due to cells freshly derived from the thymus. We report that proliferation and cytokine production decreased in thymectomized mice even at wk 4 of infection, indicating that cells that are freshly derived from thymus are the ones responding to treatment. This study indicates that once anergy has been established in MAIDS, it cannot be reversed by providing costimulation via CD28 and IL-12. Anergy of CD4 T cells in MAIDS appears to be different from that seen in other systems, both in underlying cause and in the ability of the cells to revert to a normal state." @default.
- W1520592037 created "2016-06-24" @default.
- W1520592037 creator A5003481946 @default.
- W1520592037 creator A5087475876 @default.
- W1520592037 creator A5087572646 @default.
- W1520592037 date "1997-09-01" @default.
- W1520592037 modified "2023-09-26" @default.
- W1520592037 title "CD4 T cell anergy in murine AIDS: costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells." @default.
- W1520592037 doi "https://doi.org/10.4049/jimmunol.159.5.2132" @default.
- W1520592037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9278299" @default.
- W1520592037 hasPublicationYear "1997" @default.
- W1520592037 type Work @default.
- W1520592037 sameAs 1520592037 @default.
- W1520592037 citedByCount "8" @default.
- W1520592037 crossrefType "journal-article" @default.
- W1520592037 hasAuthorship W1520592037A5003481946 @default.
- W1520592037 hasAuthorship W1520592037A5087475876 @default.
- W1520592037 hasAuthorship W1520592037A5087572646 @default.
- W1520592037 hasConcept C148125776 @default.
- W1520592037 hasConcept C159654299 @default.
- W1520592037 hasConcept C19317047 @default.
- W1520592037 hasConcept C203014093 @default.
- W1520592037 hasConcept C2776090121 @default.
- W1520592037 hasConcept C2777371288 @default.
- W1520592037 hasConcept C2778690821 @default.
- W1520592037 hasConcept C2779062720 @default.
- W1520592037 hasConcept C2780514984 @default.
- W1520592037 hasConcept C2992881475 @default.
- W1520592037 hasConcept C71924100 @default.
- W1520592037 hasConcept C86803240 @default.
- W1520592037 hasConcept C8891405 @default.
- W1520592037 hasConceptScore W1520592037C148125776 @default.
- W1520592037 hasConceptScore W1520592037C159654299 @default.
- W1520592037 hasConceptScore W1520592037C19317047 @default.
- W1520592037 hasConceptScore W1520592037C203014093 @default.
- W1520592037 hasConceptScore W1520592037C2776090121 @default.
- W1520592037 hasConceptScore W1520592037C2777371288 @default.
- W1520592037 hasConceptScore W1520592037C2778690821 @default.
- W1520592037 hasConceptScore W1520592037C2779062720 @default.
- W1520592037 hasConceptScore W1520592037C2780514984 @default.
- W1520592037 hasConceptScore W1520592037C2992881475 @default.
- W1520592037 hasConceptScore W1520592037C71924100 @default.
- W1520592037 hasConceptScore W1520592037C86803240 @default.
- W1520592037 hasConceptScore W1520592037C8891405 @default.
- W1520592037 hasIssue "5" @default.
- W1520592037 hasLocation W15205920371 @default.
- W1520592037 hasLocation W15205920372 @default.
- W1520592037 hasOpenAccess W1520592037 @default.
- W1520592037 hasPrimaryLocation W15205920371 @default.
- W1520592037 hasRelatedWork W1520592037 @default.
- W1520592037 hasRelatedWork W1551676531 @default.
- W1520592037 hasRelatedWork W1997170465 @default.
- W1520592037 hasRelatedWork W2035383673 @default.
- W1520592037 hasRelatedWork W2040572245 @default.
- W1520592037 hasRelatedWork W2079334007 @default.
- W1520592037 hasRelatedWork W2096033616 @default.
- W1520592037 hasRelatedWork W2142528939 @default.
- W1520592037 hasRelatedWork W2156051937 @default.
- W1520592037 hasRelatedWork W2755132400 @default.
- W1520592037 hasVolume "159" @default.
- W1520592037 isParatext "false" @default.
- W1520592037 isRetracted "false" @default.
- W1520592037 magId "1520592037" @default.
- W1520592037 workType "article" @default.