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- W1520632638 abstract "Schubert (1984) and Kater et al. (1988) have suggested that motility and growth at the neuronal growth cone is activated by an increase of cytosolic free calcium concentration ([Ca2+]i) above the levels found in quiescent growth cones. In order to test this model, we have used a digital imaging fluorescence microscope together with injection of the fluorescent indicator dye Fura-2 to measure [Ca2+]i in growth cones of a mammalian sympathetic neuron, the N1E-115 neuroblastoma cell. The behavior of individual growth cones, together with spontaneously varying levels of [Ca2+]i within the growth cone, were monitored for periods of up to several hours. [Ca2+]i in motile, advancing growth cones was low and equal to [Ca2+]i in quiescent growth cones. Higher values of [Ca2+]i were found in motile growth cones that were not advancing, suggesting that a small elevation of [Ca2+]i inhibits neurite extension. A further rise of [Ca2+]i above the level found in motile, nonadvancing growth cones appeared to inhibit motility and cause retraction of the growth cone back towards the cell body. Spatial gradients of [Ca2+]i within the growth cone were small and, where statistically significant, [Ca2+]i was lower by 5-10 nM in motile regions. Our results are incompatible with the model that a rise of [Ca2+]i is responsible for activating quiescent growth cones; however, our results suggest that in active growth cones [Ca2+]i can regulate morphology and behavior." @default.
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- W1520632638 date "1989-11-01" @default.
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- W1520632638 title "Elevated cytosolic calcium in the growth cone inhibits neurite elongation in neuroblastoma cells: correlation of behavioral states with cytosolic calcium concentration" @default.
- W1520632638 doi "https://doi.org/10.1523/jneurosci.09-11-04007.1989" @default.
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