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- W1520657568 abstract "hours before weighing. After weighing, they were injected intraperitoneally (IP). Food and water were then made available two hours after injection. Observations after injection were for 24 hours. The statistical test employed was the nonparametric MannWhitney U Test (Siegel, 1956). Each comparison made assumed a two tailed test and a significance level of 0.05. This test compared two independent samples and the only assumption made is that the samples are random. RESULTS. C. sculpturatus and H . suspectum venom LD50 in mice were 1.5 (1.1-1.9) mg and 3.0 (2.1-4.2) mg of venom per Kg of mouse, respectively. There was a significant difference in the lethal times for the two venoms (Table 1). At the 2 LD50 dosage level C. sculpturatus venom evoked lethal times within a relatively narrow range. This relationship was not apparent with H. suspectum venom. Thus, further tests with H. suspectum venom at increased dosage levels did not seem practical. Responses to C. sculpturatus venom in mice at increased dosage levels were studied (Table 2). When these dosage levels were plotted against mean lethal time a linear relationship could be approximated (Fig. 1). DISCUSSION. The response of a test animal varies with the type of venom injected. C. sculpturatus venom elicits convulsions and heavy salivation in the recipient. H. suspectum venom causes hypoactivity accompanied by respiratory and cardiac failure in the recipient. These venoms, however, have approximately the same LD50 when injections are made IP. If lethal time is a measure of lethality per se the two venoms should have the bulk of their lethal time" @default.
- W1520657568 created "2016-06-24" @default.
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- W1520657568 date "1966-01-01" @default.
- W1520657568 modified "2023-09-24" @default.
- W1520657568 title "LETHAL TIME AS A MEASURE OF VENOM POTENCY" @default.
- W1520657568 cites W2024169949 @default.
- W1520657568 doi "https://doi.org/10.21236/ad0821966" @default.
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