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• W1520659771 abstract "3,3′-Dipropyl-2,2′-thiadicarbocyanine iodide [DiS-C3(5)], often used as a tracer dye to assess the mitochondrial membrane potential, was investigated in detail regarding its effects on the structure and function of isolated mitochondria. As reported previously, DiS-C3(5) had an inhibitory effect on NADH-driven mitochondrial electron transfer. On the contrary, in the presence of inorganic phosphate, DiS-C3(5) showed dose-dependent biphasic effects on mitochondria energized by succinate. At higher concentrations, such as 50 µm, DiS-C3(5) accelerated mitochondrial oxygen consumption. Measurements of the permeability of DiS-C3(5)-treated mitochondrial membranes to poly(ethylene glycol) and analysis of mitochondrial configuration by transmission electron microscopy revealed that the accelerating effect of DiS-C3(5) on mitochondrial oxygen consumption reflects the induction of the mitochondrial permeability transition (PT). When the mitochondrial PT was induced by DiS-C3(5), release of mitochondrial cytochrome c was observed, as in the case of the PT induced by Ca2+. On the contrary, at a low concentration such as 5 µm, DiS-C3(5) showed an inhibitory effect on the latent oxygen consumption by mitochondria. This effect was shown to reflect inhibition of the PT induced by a low concentration of Ca2+. Furthermore, in the absence of inorganic phosphate, DiS-C3(5) caused mitochondrial swelling. Under this condition, DiS-C3(5) caused changes in the membrane status of the mitochondria, but did not induce a release of mitochondrial cytochrome c." @default.
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• W1520659771 date "2004-08-16" @default.
• W1520659771 modified "2023-10-15" @default.
• W1520659771 title "Multiple effects of DiS-C3(5) on mitochondrial structure and function" @default.
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• W1520659771 doi "https://doi.org/10.1111/j.1432-1033.2004.04294.x" @default.
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