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• W1520659786 endingPage "795" @default.
• W1520659786 startingPage "785" @default.
• W1520659786 abstract "Focal cortical dysplasia (FCD) is known to be a major cause of intractable epilepsy. The cellular mechanism(s) underlying the epileptogenicity of FCD remain largely unknown. Because recent studies indicate that metabotropic glutamate receptor subtypes (mGluRs) play a role in epileptogenesis, we investigated the expression and cellular distribution pattern of mGluRs in FCD specimens.Immunocytochemical expression of group I and group II mGluR subtypes was investigated in 15 specimens of human FCD obtained during epilepsy surgery.Strong mGluR1alpha and mGluR5 (group I mGluRs) immunoreactivity (IR) was observed in the majority of FCD specimens in dysplastic as well as in heterotopic neurons. mGluR1alpha was expressed in a subpopulation of neurons (mainly large dysplastic cells), whereas mGluR5 was represented in a higher percentage of dysplastic neuronal cells. Group II mGluRs (mGluR2/3) IR was observed less frequently than that in group I mGluRs and generally appeared in <10% of the dysplastic neurons. IR for all three mGluR subtypes was observed in balloon cells. mGluR2/3 appeared to be most frequently expressed in glial fibrillary acidic protein (GFAP)-positive balloon cells (glial type), and mGluR1alpha, in microtubule-associated protein (MAP)2-positive cells (neuronal type). mGluR5 was present in the majority of balloon cells. Occasionally glial mGluR1alpha IR was observed in bizarre glial cells with di- or multinuclei. Reactive astrocytes were intensively stained, mainly with mGluR5 and mGluR2/3.The cellular distribution of mGluR subtypes, with high expression of mGluR1alpha and mGluR5 in dysplastic neurons, suggests a possible contribution of group I mGluRs to the intrinsic and high epileptogenicity of dysplastic cortical regions." @default.
• W1520659786 created "2016-06-24" @default.
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• W1520659786 date "2003-06-01" @default.
• W1520659786 modified "2023-10-15" @default.
• W1520659786 title "Expression and Cell Distribution of Group I and Group II Metabotropic Glutamate Receptor Subtypes in Taylor-type Focal Cortical Dysplasia" @default.
• W1520659786 cites W1227775766 @default.
• W1520659786 cites W1557507893 @default.
• W1520659786 cites W1965468911 @default.
• W1520659786 cites W1968381356 @default.
• W1520659786 cites W1968692478 @default.
• W1520659786 cites W1971162500 @default.
• W1520659786 cites W1972183007 @default.
• W1520659786 cites W1974590925 @default.
• W1520659786 cites W1975424623 @default.
• W1520659786 cites W1977695003 @default.
• W1520659786 cites W1989452582 @default.
• W1520659786 cites W1992682248 @default.
• W1520659786 cites W1993938035 @default.
• W1520659786 cites W1994568892 @default.
• W1520659786 cites W1997299990 @default.
• W1520659786 cites W1998010836 @default.
• W1520659786 cites W1998171204 @default.
• W1520659786 cites W1999295475 @default.
• W1520659786 cites W2002613500 @default.
• W1520659786 cites W2004541630 @default.
• W1520659786 cites W2010016510 @default.
• W1520659786 cites W2016413308 @default.
• W1520659786 cites W2017442183 @default.
• W1520659786 cites W2017523469 @default.
• W1520659786 cites W2018840383 @default.
• W1520659786 cites W2026823130 @default.
• W1520659786 cites W2027970152 @default.
• W1520659786 cites W2031005886 @default.
• W1520659786 cites W2034003277 @default.
• W1520659786 cites W2034824489 @default.
• W1520659786 cites W2037141536 @default.
• W1520659786 cites W2043166209 @default.
• W1520659786 cites W2047648450 @default.
• W1520659786 cites W2055635898 @default.
• W1520659786 cites W2057327701 @default.
• W1520659786 cites W2061186601 @default.
• W1520659786 cites W2064052498 @default.
• W1520659786 cites W2067098758 @default.
• W1520659786 cites W2068805332 @default.
• W1520659786 cites W2072818925 @default.
• W1520659786 cites W2081496018 @default.
• W1520659786 cites W2082480208 @default.
• W1520659786 cites W2085462806 @default.
• W1520659786 cites W2085583043 @default.
• W1520659786 cites W2087237129 @default.
• W1520659786 cites W2088980354 @default.
• W1520659786 cites W2091341053 @default.
• W1520659786 cites W2092843300 @default.
• W1520659786 cites W2093247684 @default.
• W1520659786 cites W2093950888 @default.
• W1520659786 cites W2095311852 @default.
• W1520659786 cites W2105487742 @default.
• W1520659786 cites W2113533823 @default.
• W1520659786 cites W2129393918 @default.
• W1520659786 cites W2130215954 @default.
• W1520659786 cites W2135010285 @default.
• W1520659786 cites W2150398616 @default.
• W1520659786 cites W2152516757 @default.
• W1520659786 cites W2152922912 @default.
• W1520659786 cites W2154193664 @default.
• W1520659786 cites W2154508911 @default.
• W1520659786 cites W2159484326 @default.
• W1520659786 cites W2164930173 @default.
• W1520659786 cites W2183240813 @default.
• W1520659786 cites W2238387233 @default.
• W1520659786 cites W2264378548 @default.
• W1520659786 cites W2341786819 @default.
• W1520659786 cites W2408779311 @default.
• W1520659786 cites W2410004099 @default.
• W1520659786 cites W2414176354 @default.
• W1520659786 cites W34709307 @default.
• W1520659786 cites W4234506391 @default.
• W1520659786 cites W4319053752 @default.
• W1520659786 cites W4322703206 @default.
• W1520659786 cites W146906401 @default.
• W1520659786 doi "https://doi.org/10.1046/j.1528-1157.2003.54802.x" @default.
• W1520659786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12790891" @default.
• W1520659786 hasPublicationYear "2003" @default.
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