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• W1520678077 abstract "Staphylococcal δ-toxin, a 26-residue amphiphilic peptide is lytic for cells and phospholipid vesicles and is assumed to insert as an amphipathic helix and oligomerize in membranes. For the first time, the relationship between these properties and toxin structure is investigated by means of eight synthetic peptides, one identical in sequence to the natural toxin, five 26-residue analogues and two shorter peptides corresponding to residues 1–11 and 11–26. These peptides were designed by the Edmundson wheel axial projection in order to maintain: (a) the hydrophilic/hydrophobic balance while rationalizing the sequence, (b) the α-helical configuration and (c) the common epitopic structure. The fluorescence of the single Trp residue was used to monitor the behaviour of the natural toxin and analogues. All 26-residue analogues were hemolytically active although to a lesser extent than natural toxin. The peptide of residues 11–26 bound lipids weakly and was hemolytic at high concentration. The peptide of residues 1–11 did not bind lipids and was hemolytically inactive. All peptides except the latter crossreacted in immunoprecipitation tests with the natural toxin. The study of a 26-residue analogue by circular dichroism revealed and α-helical configuration in both the free and lipid-bound state. Changes in the fluorescence of the peptides in the presence of lipid micelles and bilayers varied according to the position of the reporter group. When bound to lipids, Trp5, Trp16 and the Fmoc-1 positions of the analogues became buried while Trp15 of the natural toxin and its synthetic replicate remained more exposed. All changes are rationalized by the proposal of an amphipathic helix whose hydrophobic face is embedded within the apolar core of bilayers while the hydrophilic and charged face remains more exposed to solvent." @default.
• W1520678077 created "2016-06-24" @default.
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• W1520678077 date "1989-08-01" @default.
• W1520678077 modified "2023-10-17" @default.
• W1520678077 title "Interaction of staphylococcal delta-toxin and synthetic analogues with erythrocytes and phospholipid vesicles. Biological and physical properties of the amphipathic peptides" @default.
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• W1520678077 doi "https://doi.org/10.1111/j.1432-1033.1989.tb14939.x" @default.
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