FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520692677> ?p ?o ?g. }

• W1520692677 abstract "The 4D NURBS-based Cardiac-Torso (NCAT) phantom, which provides a realistic model of the normal human anatomy and cardiac and respiratory motions, is used in medical imaging research to evaluate and improve imaging devices and techniques, especially dynamic cardiac applications. One limitation of the phantom is that it lacks the ability to accurately simulate altered functions of the heart that result from cardiac pathologies such as coronary artery disease (CAD). The goal of this work was to enhance the 4D NCAT phantom by incorporating a physiologically based, finite-element (FE) mechanical model of the left ventricle (LV) to simulate both normal and abnormal cardiac motions. The geometry of the FE mechanical model was based on gated high-resolution x-ray multi-slice computed tomography (MSCT) data of a healthy male subject. The myocardial wall was represented as transversely isotropic hyperelastic material, with the fiber angle varying from -90 degrees at the epicardial surface, through 0 degrees at the mid-wall, to 90 degrees at the endocardial surface. A time varying elastance model was used to simulate fiber contraction, and physiological intraventricular systolic pressure-time curves were applied to simulate the cardiac motion over the entire cardiac cycle. To demonstrate the ability of the FE mechanical model to accurately simulate the normal cardiac motion as well abnormal motions indicative of CAD, a normal case and two pathologic cases were simulated and analyzed. In the first pathologic model, a subendocardial anterior ischemic region was defined. A second model was created with a transmural ischemic region defined in the same location. The FE based deformations were incorporated into the 4D NCAT cardiac model through the control points that define the cardiac structures in the phantom which were set to move according to the predictions of the mechanical model. A simulation study was performed using the FE-NCAT combination to investigate how the differences in contractile function between the subendocardial and transmural infarcts manifest themselves in myocardial SPECT images. The normal FE model produced strain distributions that were consistent with those reported in the literature and a motion consistent with that defined in the normal 4D NCAT beating heart model based on tagged MRI data. The addition of a subendocardial ischemic region changed the average transmural circumferential strain from a contractile value of 0.19 to a tensile value of 0.03. The addition of a transmural ischemic region changed average circumferential strain to a value of 0.16, which is consistent with data reported in the literature. Model results demonstrated differences in contractile function between subendocardial and transmural infarcts and how these differences in function are documented in simulated myocardial SPECT images produced using the 4D NCAT phantom. In comparison to the original NCAT beating heart model, the FE mechanical model produced a more accurate simulation for the cardiac motion abnormalities. Such a model, when incorporated into the 4D NCAT phantom, has great potential for use in cardiac imaging research. With its enhanced physiologically-based cardiac model, the 4D NCAT phantom can be used to simulate realistic, predictive imaging data of a patient population with varying whole-body anatomy and with varying healthy and diseased states of the heart that will provide a known truth from which to evaluate and improve existing and emerging 4D imaging techniques used in the diagnosis of cardiac disease." @default.
• W1520692677 created "2016-06-24" @default.
• W1520692677 creator A5005183671 @default.
• W1520692677 creator A5034237477 @default.
• W1520692677 creator A5046139669 @default.
• W1520692677 creator A5054820125 @default.
• W1520692677 creator A5061057386 @default.
• W1520692677 date "2006-08-02" @default.
• W1520692677 modified "2023-09-23" @default.
• W1520692677 title "Normal and Pathological NCAT Image and Phantom Data Based on Physiologically Realistic Left Ventricle Finite-Element Models" @default.
• W1520692677 hasPublicationYear "2006" @default.
• W1520692677 type Work @default.
• W1520692677 sameAs 1520692677 @default.
• W1520692677 citedByCount "0" @default.
• W1520692677 crossrefType "journal-article" @default.
• W1520692677 hasAuthorship W1520692677A5005183671 @default.
• W1520692677 hasAuthorship W1520692677A5034237477 @default.
• W1520692677 hasAuthorship W1520692677A5046139669 @default.
• W1520692677 hasAuthorship W1520692677A5054820125 @default.
• W1520692677 hasAuthorship W1520692677A5061057386 @default.
• W1520692677 hasConcept C104293457 @default.
• W1520692677 hasConcept C105702510 @default.
• W1520692677 hasConcept C121332964 @default.
• W1520692677 hasConcept C126838900 @default.
• W1520692677 hasConcept C135628077 @default.
• W1520692677 hasConcept C136229726 @default.
• W1520692677 hasConcept C147370603 @default.
• W1520692677 hasConcept C164705383 @default.
• W1520692677 hasConcept C184050105 @default.
• W1520692677 hasConcept C2524010 @default.
• W1520692677 hasConcept C2776127602 @default.
• W1520692677 hasConcept C2778921608 @default.
• W1520692677 hasConcept C2910288590 @default.
• W1520692677 hasConcept C2989005 @default.
• W1520692677 hasConcept C33923547 @default.
• W1520692677 hasConcept C39078644 @default.
• W1520692677 hasConcept C523889960 @default.
• W1520692677 hasConcept C57900726 @default.
• W1520692677 hasConcept C62520636 @default.
• W1520692677 hasConcept C71924100 @default.
• W1520692677 hasConcept C84393581 @default.
• W1520692677 hasConcept C97355855 @default.
• W1520692677 hasConcept C99398487 @default.
• W1520692677 hasConceptScore W1520692677C104293457 @default.
• W1520692677 hasConceptScore W1520692677C105702510 @default.
• W1520692677 hasConceptScore W1520692677C121332964 @default.
• W1520692677 hasConceptScore W1520692677C126838900 @default.
• W1520692677 hasConceptScore W1520692677C135628077 @default.
• W1520692677 hasConceptScore W1520692677C136229726 @default.
• W1520692677 hasConceptScore W1520692677C147370603 @default.
• W1520692677 hasConceptScore W1520692677C164705383 @default.
• W1520692677 hasConceptScore W1520692677C184050105 @default.
• W1520692677 hasConceptScore W1520692677C2524010 @default.
• W1520692677 hasConceptScore W1520692677C2776127602 @default.
• W1520692677 hasConceptScore W1520692677C2778921608 @default.
• W1520692677 hasConceptScore W1520692677C2910288590 @default.
• W1520692677 hasConceptScore W1520692677C2989005 @default.
• W1520692677 hasConceptScore W1520692677C33923547 @default.
• W1520692677 hasConceptScore W1520692677C39078644 @default.
• W1520692677 hasConceptScore W1520692677C523889960 @default.
• W1520692677 hasConceptScore W1520692677C57900726 @default.
• W1520692677 hasConceptScore W1520692677C62520636 @default.
• W1520692677 hasConceptScore W1520692677C71924100 @default.
• W1520692677 hasConceptScore W1520692677C84393581 @default.
• W1520692677 hasConceptScore W1520692677C97355855 @default.
• W1520692677 hasConceptScore W1520692677C99398487 @default.
• W1520692677 hasLocation W15206926771 @default.
• W1520692677 hasOpenAccess W1520692677 @default.
• W1520692677 hasPrimaryLocation W15206926771 @default.
• W1520692677 hasRelatedWork W1541835892 @default.
• W1520692677 hasRelatedWork W1566220841 @default.
• W1520692677 hasRelatedWork W1972143582 @default.
• W1520692677 hasRelatedWork W1988042964 @default.
• W1520692677 hasRelatedWork W2007163074 @default.
• W1520692677 hasRelatedWork W2008729241 @default.
• W1520692677 hasRelatedWork W2041866869 @default.
• W1520692677 hasRelatedWork W2096430891 @default.
• W1520692677 hasRelatedWork W2129234235 @default.
• W1520692677 hasRelatedWork W2130505007 @default.
• W1520692677 hasRelatedWork W2136992899 @default.
• W1520692677 hasRelatedWork W2159681526 @default.
• W1520692677 hasRelatedWork W2164236814 @default.
• W1520692677 hasRelatedWork W2186847122 @default.
• W1520692677 hasRelatedWork W2290973085 @default.
• W1520692677 hasRelatedWork W2425921082 @default.
• W1520692677 hasRelatedWork W2504197019 @default.
• W1520692677 hasRelatedWork W2536886752 @default.
• W1520692677 hasRelatedWork W2975627646 @default.
• W1520692677 hasRelatedWork W2995528796 @default.
• W1520692677 isParatext "false" @default.
• W1520692677 isRetracted "false" @default.
• W1520692677 magId "1520692677" @default.
• W1520692677 workType "article" @default.